Frequency of glucose-6-phosphate dehydrogenase enzyme (G6PD) deficiency in newborns with prolonged jaundice

TAŞTANOĞLU, Hüseyin

doi:10.14744/zkmj.2021.88709

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“…Furthermore, previously studies conducted in international population have evaluated the genetic and molecular profile of these neonates which is not yet studied in our population. The understanding of these characteristics is important particularly in patients with prolonged jaundice as [21][22][23] stated in various studies as well to effectively manage the disease and control its prevalence in the future.…”

Section: Deficiencymentioning

confidence: 99%

Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency in Neonates Presenting with Indirect Hyperbilirubinemia

Rani

2023

J Dow Univ Health Sci

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Objective: To determine the frequency of glucose-6-phosphate dehydrogenase (G6PD) deficiency in neonates presenting with indirect hyperbilirubinemia. Methods: A prospective cross-sectional study was conducted at Neonatal intensive care unit (NICU) of National Institute of Child Health, Karachi from August 2020 to July 2021. All neonates with either gender born with indirect hyperbilirubinemia >5mg/dl admitted in NICU were consecutively enrolled. G6PD deficiency along with baseline and laboratory characteristics were observed. The presence of G6PD level of <1.3 U/g Hb was labeled as G6PD deficiency. Results: Of 228 neonates, the mean age was 8.58 ±3.68 days. There were 153 (67.1%) males and 75 (32.9%) females. The frequency of G6PD deficiency was found to be 72 (31.6%). The mean weight was significantly higher among neonates with G6PD deficiency as compared to the patients with no G6PD deficiency, i.e., 2.53 ±0.48 vs. 2.37 ±0.56 (p-value 0.035). A significant difference of hemoglobin level (p-value <0.001), serum total bilirubin level (pvalue <0.001), and serum indirect bilirubin level (p-value0.001) was observed in between G6PD deficient and nondeficient neonates. Increased reticulocyte count was also found significantly higher in neonates with G6PD deficiency as compared to the neonates without G6PD deficiency, i.e., 69 (95.8%) and 34 (21.8%) respectively (pvalue <0.001). Conclusion: G6PD deficiency was considerably prevalent in neonates with indirect hyperbilirubinemia. Moreover, hemoglobin level, serum total bilirubin level, serum indirect bilirubin level, and increased reticulocyte count was also observed significant contributing factors for G6PD deficiency.

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Section: Deficiencymentioning

confidence: 99%

Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency in Neonates Presenting with Indirect Hyperbilirubinemia

Rani

2023

J Dow Univ Health Sci

View full text Add to dashboard Cite

show abstract

Frequency of glucose-6-phosphate dehydrogenase enzyme (G6PD) deficiency in newborns with prolonged jaundice

Cited by 1 publication

References 0 publications

Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency in Neonates Presenting with Indirect Hyperbilirubinemia

Glucose-6-Phosphate Dehydrogenase (G6PD) Deficiency in Neonates Presenting with Indirect Hyperbilirubinemia

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