Frequency of Hepatocellular Carcinoma and Associated Sociodemographic Factors in Treated Patients of Chronic Hepatitis C

Tariq, Rabia; Abbas, Anum; Saeed, Farrukh; Qureshi, Zeeshan

doi:10.51253/pafmj.v71isuppl-1.2602

Cited by 2 publications

(2 citation statements)

References 17 publications

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“…The manifestation of hepatitis can be acute or chronic, potentially progressing to severe conditions like liver cirrhosis or cancer. While there are nonviral causes such as drugs and autoimmune disorders, viral infections remain the predominant cause (1)(2)(3).…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Hepatitis B and C in Pakistan from 2001 to 2022: A Systematic Review

Akbar Jamali,

Noonari,

Khuhro

et al. 2023

JHRR

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Background: Hepatitis B and C represent a significant public health concern globally, with a substantial burden in developing countries, particularly Pakistan. The country's diverse demographic and socio-economic landscape presents challenges in the surveillance and management of these infectious diseases. Objective: This systematic review aims to consolidate and analyse the prevalence data of Hepatitis B and C infections reported across Pakistan from 2001 to 2022 to understand the epidemiological trends and to inform public health interventions. Methods: A thorough search of various research databases was conducted to identify studies that reported the prevalence of Hepatitis B surface antigen (HBsAg) and anti-Hepatitis C virus (anti-HCV) antibodies. Studies were selected based on inclusion criteria focused on the population of Pakistan between 2001 and 2022. Data extraction was systematic, although a comprehensive quality assessment of each study was not completed. Results: The review included 54 studies with varying sample sizes and methodologies, including ELISA, ICT, PCR, and other serological assays. Prevalence rates for HBsAg and anti-HCV varied significantly, with HBsAg ranging from 0.9% to 44.4% and anti-HCV from 0.3% to 62.6%. These findings highlight a considerable regional variability and suggest an upward trend in HCV prevalence over the past two decades. Conclusion: The elevated prevalence rates of Hepatitis B and C across Pakistan underscore the need for robust public health policies, standardized surveillance, and targeted interventions. Despite the systematic approach to data extraction, the review is limited by the absence of a comprehensive quality assessment, which is essential for future research to build upon.

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Section: Introductionmentioning

confidence: 99%

Prevalence of Hepatitis B and C in Pakistan from 2001 to 2022: A Systematic Review

Akbar Jamali,

Noonari,

Khuhro

et al. 2023

JHRR

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“…58% of the cases in Pakistan present with chronic hepatitis C as an underlying cause of HCC and 25.3% have hepatitis B 5 . There are many reasons like sedentary lifestyle, obesity and diabetes that have contributed in increased prevalence of non hepatitis HCC 6 .…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Co-Relation between BCLC Stage of HCC and Alpha-Fetoprotein Levels

Hamayun¹,

Gardezi²,

Niazi³

et al. 2022

PJMHS

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Background: One of the leading cancers worldwide is the hepatocellular carcinoma, ranked as the 6th most common cancers. Aim: To evaluate the co-relation between BCLC staging of HCC and alpha fetoprotein levels. Study design: Cross-sectional study. Methodology: Patients (n=90) of either gender irrespective of age who were diagnosed with hepatocellular carcinoma were included into the study. Clinical examination was performed and findings were noted. Eastern cooperative oncology group ECOG scoring system was used to identify the functional performance status of the patients. Hepatocellular carcinoma staging was done using the BCLC scoring system. Complete blood counts, Liver function tests (LFTS), INR, alpha fetoprotein levels, viral serology for hepatits and ultrasonography of abdomen were performed for all the patients. Data was analyzed using SPSS version 26. Results were presented as frequency and percentage. Age was presented as mean± SD. Results: Mean AFP levels were 400.7±305.4 IU/ml with a range of 8.50- 1015 IU/ml. 3(3.3%) patients were in BCLC stage 0, 23(25.6%) were in stage A, 33(36.7%) in stage B, 15(16.7%) in stage C and 16 (17.8%) in stage D. Results showed significant positive correlation between BCLC staging and AFP levels (r=o.834, p=0.001). Conclusion: It was concluded that Hep C followed by Hep B was the main cause of HCC. AFP has a significant diagnostic and prognostic value with positive co-relation with HCC. Keywords: Alpha-Fetoprotein, BCLC Staging, HCC and Liver Disease.

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Frequency of Hepatocellular Carcinoma and Associated Sociodemographic Factors in Treated Patients of Chronic Hepatitis C

Cited by 2 publications

References 17 publications

Prevalence of Hepatitis B and C in Pakistan from 2001 to 2022: A Systematic Review

Prevalence of Hepatitis B and C in Pakistan from 2001 to 2022: A Systematic Review

Evaluation of Co-Relation between BCLC Stage of HCC and Alpha-Fetoprotein Levels

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