Frequency of HLA-A*03 associates with HIV-1 infection in a Chinese cohort

Zhang, WeiLun; Wang, Li; Hong, Kui; Liu, Yanxin; Su, Bing; Xu, Chao; Xu, Jianqin; Ruan, Yuhua; Shao, Yiming; Zheng, Dexian

doi:10.1007/s11427-013-4555-4

Cited by 6 publications

(6 citation statements)

References 26 publications

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“…This early observation of positive association of HLA-A03 with LTNP is now confirmed with our larger and stricter Spanish LTNP cohort. Otherwise, A03 has also occasionally been associated with populations of HIV-infected patients other than LTNP [37, 47]. As for HLA-A03, we also describe a significant association of the HLA-B52 allele with delayed disease progression in the Spanish cohort of LTNP patients, confirming an international HIV controllers study [22] and a single earlier report weakly associating HLA-B52 with non-progression in a small Brazilian cohort of HIV-1 infected individuals [48].…”

Section: Discussionmentioning

confidence: 99%

Novel association of five HLA alleles with HIV-1 progression in Spanish long-term non progressor patients

et al. 2019

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Certain host genetic variants, especially in the human leucocyte antigen (HLA) region, are associated with different progression of HIV-1-induced diseases and AIDS. Long term non progressors (LTNP) represent only the 2% of infected patients but are especially relevant because of their efficient HIV control. In this work we present a global analysis of genetic data in the large national multicenter cohort of Spanish LTNP, which is compared with seronegative individuals and HIV-positive patients. We have analyzed whether several single-nucleotide polymorphisms (SNPs) including in key genes and certain HLA-A and B alleles could be associated with a specific HIV phenotype. A total of 846 individuals, 398 HIV-1-positive patients (213 typical progressors, 55 AIDS patients, and 130 LTNPs) and 448 HIV-negative controls, were genotyped for 15 polymorphisms and HLA-A and B alleles. Significant differences in the allele frequencies among the studied populations identified 16 LTNP-associated genetic factors, 5 of which were defined for the first time as related to LTNP phenotype: the protective effect of HLA-B39, and the detrimental impact of HLA-B18, -A24, -B08 and –A29. The remaining eleven polymorphisms confirmed previous publications, including the protective alleles HLA-B57, rs2395029 (HCP5), HLA bw4 homozygosity, HLA-B52, HLA-B27, CCR2 V64I, rs9264942 (HLA-C) and HLA-A03; and the risk allele HLA bw6 homozygosity. Notably, individual Spanish HIV-negative individuals had an average of 0.12 protective HLA alleles and SNPs, compared with an average of 1.43 protective alleles per LTNP patient, strongly suggesting positive selection of LTNP. Finally, stratification of LTNP according to viral load showed a proportional relationship between the frequency of protective alleles with control of viral load. Interestingly, no differences in the frequency of protection/risk polymorphisms were found between elite controllers and LTNPs maintaining viral loads <2.000 copies/mL throughout the follow-up.

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Section: Discussionmentioning

confidence: 99%

Novel association of five HLA alleles with HIV-1 progression in Spanish long-term non progressor patients

et al. 2019

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“…The CYP21A1P/CYP21A2 CH-1 chimera (junction site p.G110fs ^ p.I172N) was found to be associated with the HLA-A*03 allele. The A*03 allele has been found to have a potential protective role in HIV-1 infection and viremia control in a Chinese population (Zhang et al, 2013). The CYP21A1P/CYP21A2 CH-5 chimera (junction site p. L307fs ^ p.Q318X) was significantly associated with the HLA-C*06-DRB1*07 haplotype.…”

Section: Discussionmentioning

confidence: 99%

Revisiting the association of HLA alleles and haplotypes with CYP21A2 mutations in a large cohort of patients with congenital adrenal hyperplasia

Jayakrishnan

Lao

Adams

et al. 2019

Gene

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The CYP21A2 gene encoding 21-hydroxylase is on chromosome 6p21.3 within the human leukocyte antigen (HLA) class III major histocompatibility complex and an association between congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency and HLA class I and II alleles has been shown in genetically isolated populations. One-third of CAH causing alleles are 30-kb deletions due to homologous recombination events between active and pseudogenes resulting in chimeric genes. The aim of this study was to re-visit the association between the CYP21A2 variants and HLA polymorphisms in a large ethnically diverse cohort of patients with CAH who underwent comprehensive CYP21A2 genotyping, including specification of chimeric gene subtypes (CAH CH-1 through CH-9 of CYP21A1P/CYP21A2 chimeras; CAH-X CH-1 through CH-3 of TNXA/TNXB chimeras) in alleles with 30-kb deletions. The study population included 201 patients (86 males, 115 females, age 3–75 years) with CAH due to 21-hydroxylase deficiency (159 classic, 42 nonclassic) and 194 parents. Based on the availability of parental genotype, we determined the haplotypes of CYP21A2 mutations and HLA types in 95 probands (190 alleles). Five prevalent haplotype associations were found: p.V281L and B*14-C*08 (P <0.0001); p.I172N and DQB1*03 (P = 0.035); and of the chimeric genes caused by 30-kb deletions: CH-1 and A*03 (P =0.033); CH-5 and C*06-DRB1*07 (P < 0.0001); and CAH-X CH-1 and DQB1*03 (P = 0.004). Our findings show that a number of associations between HLA alleles and haplotypes and CYP21A2 mutations, including large 30-kb deletions, exist commonly across ethnicities. These HLA associations may have clinical implications for patients with CAH and may provide insight into the genetics of this highly complex region of the human genome.

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“…In northern Han Chinese population, the most common HLA-A-B haplotypes (HF>0. 0300) were A* 30-B* 13 , A* 02-B* 46 , A* 33-B* 58 , A* 33-B* 44 , A* 02-B* 40 [ 20 ]. We also found these HLA haplotypes were most common in the SFTS patient group and in the control group except for HLA-A* 33-B* 58 .…”

Section: Discussionmentioning

confidence: 99%

“…Studies showed that HLA was related to ankylosing spondylitis, diabetes, psoriasis and other autoimmune diseases [ 17 – 19 ]. It also correlated to AIDS, hepatitis B and other viral infections [ 20 – 22 ], but the correlation between HLA polymorphism and SFTS had not yet investigated. In this study, we analyzed the frequency of three important HLA alleles and haplotypes comprised by these alleles in SFTS patients and healthy individuals to determine whether HLA alleles and/or haplotypes correlated to the occurrence of SFTS.…”

Section: Introductionmentioning

confidence: 99%

Correlation Between HLA-A, B and DRB1 Alleles and Severe Fever with Thrombocytopenia Syndrome

Ding

Zhang²,

Zhang

et al. 2016

PLoS Negl Trop Dis

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ObjectiveSevere fever with thrombocytopenia syndrome (SFTS) is an emerging hemorrhagic fever caused by a tick-borne bunyavirus (SFTSV) in East Asian countries. The role of human leukocyte antigen (HLA) in resistance and susceptibility to SFTSV is not known. We investigated the correlation of HLA locus A, B and DRB1 alleles with the occurrence of SFTS.MethodsA total of 84 confirmed SFTS patients (patient group) and 501 unrelated non-SFTS patients (healthy individuals as control group) from Shandong Province were genotyped by PCR-sequence specific oligonucleotide probe (PCR-SSOP) for HLA-A, B and DRB1 loci.Allele frequency was calculated and compared using χ2 test or the Fisher's exact test. A corrected P value was calculated with a bonferronis correction. Odds Ratio (OR) and 95% confidence intervals (CI) were calculated by Woolf’s method.ResultsA total of 11 HLA-A, 23 HLA-B and 12 HLA-DRB1 alleles were identified in the patient group, whereas 15 HLA-A, 30 HLA-B and 13 HLA-DRB1 alleles were detected in the control group. The frequencies of A*30 and B*13 in the SFTS patient group were lower than that in the control group (P = 0.0341 and 0.0085, Pc = 0.5115 and 0.252). The ORs of A*30 and B*13 in the SFTS patient group were 0.54 and 0.49, respectively. The frequency of two-locus haplotype A*30-B*13 was lower in the patient group than in the control group(5.59% versus 12.27%, P = 0.037,OR = 0.41, 95%CI = 0.18–0.96) without significance(Pc>0.05). A*30-B*13-DRB1*07 and A*02-B*15-DRB1*04 had strong associations with SFTS resistance and susceptibility respectively (Pc = 0.0412 and 0.0001,OR = 0.43 and 5.07).ConclusionThe host HLA class I polymorphism might play an important role with the occurrence of SFTS. Negative associations were observed with HLA-A*30, HLA-B*13 and Haplotype A*30-B*13, although the associations were not statistically significant. A*30-B*13-DRB1*07 had negative correlation with the occurrence of SFTS; in contrast, haplotype A*02-B*15-DRB1*04 was positively correlated with SFTS.

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Frequency of HLA-A*03 associates with HIV-1 infection in a Chinese cohort

Cited by 6 publications

References 26 publications

Novel association of five HLA alleles with HIV-1 progression in Spanish long-term non progressor patients

Novel association of five HLA alleles with HIV-1 progression in Spanish long-term non progressor patients

Revisiting the association of HLA alleles and haplotypes with CYP21A2 mutations in a large cohort of patients with congenital adrenal hyperplasia

Correlation Between HLA-A, B and DRB1 Alleles and Severe Fever with Thrombocytopenia Syndrome

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