Frequency of HLA‑G UTR‑1/UTR‑3/UTR‑7 in women with unexplained recurrent spontaneous abortion

Bai, Wei; Zhi, Lin; Ye, Jin; Zhou, Linshuang; Xi, Jingqiao; Cai, Wenpin

doi:10.3892/etm.2022.11665

Cited by 4 publications

(3 citation statements)

References 29 publications

(49 reference statements)

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“…Twenty‐five articles were included in the meta‐analysis of the association between RM and the 14‐bp insertion/deletion (14‐bp ins/del) polymorphism in the HLA‐G 3ʹ‐UTR 30,32,36–58 . Four studies did not conform to HWE 38,44,46,47 .…”

Section: Resultsmentioning

confidence: 99%

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Association of human leukocyte antigen‐G and ‐F with recurrent miscarriage and implantation failure: A systematic review and meta‐analysis

Han,

Xia,

Zhu

et al. 2023

American J Rep Immunol

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ProblemThe immune system plays an essential role in embryonic implantation and pregnancy, but the molecular details remain controversial. In the past four decades, human leukocyte antigen (HLA)‐G and ‐F have garnered significant attention.Method of StudyMEDLINE, EMBASE, Web of Science, and the Cochrane Trials Registry were searched from their inception dates until December 2022. Studies were selected following PRISMA guidelines. Meta‐analyses were used to assess the relationship of soluble HLA‐G (sHLA‐G) and HLA‐G 3′‐untranslated region polymorphisms with recurrent miscarriage (RM) and recurrent implantation failure (RIF). Narrative synthesis was conducted to determine the association of RM with other single nucleotide polymorphisms (SNPs) and HLA‐G protein in tissues and of RIF with HLA‐F. Risk‐of‐bias was assessed using ROBINS‐I. Publication bias was assessed using Egger's and Begg's tests.ResultsFinally, 42 articles were eligible for inclusion in the systematic review (32 in the meta‐analysis; 13 in narrative synthesis). We found a significant association between the 14‐bp ins/del HLA‐G polymorphism and RM risk, but no definitive association with RIF risk. Women with RM had lower blood concentrations of sHLA‐G during pregnancy and non‐pregnancy than did controls. For women in the RIF group, no significant difference was found.ConclusionHLA‐G protein and gene expression levels may be closely related to RM. The relevance of HLA‐G to RIF is still being determined. A narrative synthesis of current studies has shown that HLA‐F is likely associated with RIF.

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Section: Resultsmentioning

confidence: 99%

“…Seven HLA-G SNPS have been reported to be associated with RM at least three times in the published literature. 32,37,40,43 Table 2 shows the results of the meta-analysis of these seven SNPs. The control group in each study was in HWE ( Table S5B-H).…”

Section: Other Hla-g 3ʹutr Polymorphisms and Rmmentioning

confidence: 99%

Association of human leukocyte antigen‐G and ‐F with recurrent miscarriage and implantation failure: A systematic review and meta‐analysis

Han,

Xia,

Zhu

et al. 2023

American J Rep Immunol

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“…In addition, human leukocyte antigen G (HLA-G), expressed on trophoblastic cell surfaces, seems to be one of the main molecules involved in the modulation of both local and systemic maternal immune responses. It was demonstrated that HLA-G 3'UTR polymorphisms and haplotypes may be involved in unexplained recurrent spontaneous abortion (URSA) and may be a predictor of pregnancy outcome [28].…”

mentioning

confidence: 99%

Reproductive Immunology and Pregnancy 3.0

Szukiewicz

2023

IJMS

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Association of HLA‐G 3′‐UTR Haplotypes With Recurrent Spontaneous Abortion in Women From Northwest Iran

Moqadami,

Khalaj‐Kondori,

Haghi

2024

Birth Defects Research

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Background and Objective(s)Human leukocyte antigen‐G (HLA‐G) is a critical protein in immune regulation and tolerance. Recurrent spontaneous abortion (RSA) is a complex disease influenced by genetic, immune dysfunction, and environmental factors. This study investigates the role of HLA‐G polymorphisms in the development of RSA.MethodsBlood samples were collected from 80 women with RSA and 200 women without a history of RSA. After DNA extraction, PCR was used to sequence the 3′‐UTR region. Allelic and genotypic frequencies were analyzed, and Haploview software was used for haplotype analysis.ResultsIndividual polymorphisms did not significantly differ between the two groups. However, haplotype analysis revealed significant differences. The UTR‐2 haplotype was more frequent in the RSA group compared to the healthy control group (p = 0.020), suggesting a potential association. Conversely, the UTR‐4 haplotype had a significantly lower frequency in the RSA group (p = 0.041), indicating a protective role against RSA.ConclusionsWhile individual polymorphisms did not differ significantly, haplotype analysis identified significant associations with RSA. These findings provide valuable insights into the genetic basis of the disease and may contribute to the development of new treatments and diagnostic tools.

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Frequency of HLA‑G UTR‑1/UTR‑3/UTR‑7 in women with unexplained recurrent spontaneous abortion

Cited by 4 publications

References 29 publications

Association of human leukocyte antigen‐G and ‐F with recurrent miscarriage and implantation failure: A systematic review and meta‐analysis

Association of human leukocyte antigen‐G and ‐F with recurrent miscarriage and implantation failure: A systematic review and meta‐analysis

Reproductive Immunology and Pregnancy 3.0

Association of HLA‐G 3′‐UTR Haplotypes With Recurrent Spontaneous Abortion in Women From Northwest Iran

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