Frequency of human papillomavirus infection in patients with gastrointestinal cancer

Roesch-Dietlen, F.; Cano-Contreras, A.D.; Sánchez-Maza, Y.J.; Espinosa-González, J.M.; Vazquez-Prieto, Marcela Alejandra; Díaz-Roesch, F.; Carrasco-Arróniz, Miguel Ángel; Cruz-Palacios, A; Grube-Pagola, Peter; Sumoza-Toledo, Adriana; Vivanco-Cid, Héctor; Mellado-Sánchez, Gabriela; Meixueiro-Daza, Arturo; Silva-Cañetas, C.S.; Carrillo-Toledo, M.G.; Lagunes-Torres, R.; Amieva-Balmori, Mercedes; Gómez-Castaño, P.C.; Reyes-Huerta, Job; Remes-Troche, José María

doi:10.1016/j.rgmxen.2017.09.002

Cited by 8 publications

(8 citation statements)

References 20 publications

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“…In contrast, Kirgan and collaborators reported a viral prevalence of 97% in the CRC tissues and 23% in matched normal colon mucosa for HPV, with a significant association between a HPV infection and the CRC risk [ 99 ]. Based on such heterogeneous data, other meta-analyses confirmed a Papillomavirus prevalence of 42–83% in the CRC tissues [ 100 , 101 , 102 , 103 ], and reported ORs of 5-10 for the CRC risk upon infection with HPV [ 104 , 105 ], which is in line with the value of the 4.56 (95% CI: 0.99–21.03) we observed in our study.…”

Section: Discussionsupporting

confidence: 91%

Involvement of HHV-4 (Epstein–Barr Virus) and HHV-5 (Cytomegalovirus) in Inflammatory Bowel Disease and Colorectal Cancer: A Meta-Analysis

Marongiu

Venturelli

Allgayer

2022

Cancers

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Gastrointestinal diseases (GDs) include colorectal cancer (CRC), gastric cancer (GC), and inflammatory bowel disease (IBD). CRC and GC are typically diagnosed at later stages of development, reducing patients’ chances of survival. IBD is characterized by chronic intestinal inflammation and is a significant risk factor for the development of CRC. Chronic bacterial infections have been shown to promote some GDs, but the role of viruses in the etiology of these diseases is less clear. The present meta-analysis retrieved literature on the viral prevalence in GD patients, measuring the GD risk in odd ratios. By quantifying the study heterogeneity, the literature bias was fundamentally included in the analysis. The analysis also included 11 metagenomic studies. Our meta-analysis retrieved 11,413 studies, with 196 suitable for analysis. HHV-4 (Epstein–Barr virus) was identified as a significant risk factor for the development of IBD, and HHV-5 (cytomegalovirus) as a risk factor for both CRC and IBD. Polyomaviruses and the Hepatitis B virus were also, less strongly, involved in the risk of CRC and IBD. No relations withstanding the literature bias were identified for GC. The study discusses these findings, as well as the role of other viruses in the etiology of CRC and IBD.

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Section: Discussionsupporting

confidence: 91%

Involvement of HHV-4 (Epstein–Barr Virus) and HHV-5 (Cytomegalovirus) in Inflammatory Bowel Disease and Colorectal Cancer: A Meta-Analysis

Marongiu

Venturelli

Allgayer

2022

Cancers

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“…The wide anatomical distribution of HPV infections in tumor tissue with colorectal cancer implies that HPV infection in colorectal cancer is not the result of retrograde viral transmission from the anogenital area and the possibility of hematogenous dissemination is not ruled out. There is evidence of HPV infections in newborns and virgins, which supports that the transmission of HPV through other non-sexual routes may exist [7,[51][52][53][54][55][56]; Since HPV infection is an STI, sexual behavior should be investigated.…”

Section: Discussionmentioning

confidence: 99%

“…The high percentage of HPV-16 genome integration in the host genome supports the possibility that HPV may have a role in colorectal carcinogenesis. Despite the high prevalence of infection in colorectal tumors with a high-risk type of HPV (HPV-16) and evidence of viral genome integration, HPV infections should be evaluated and whether the E6 and E7 oncoproteins are express and contribute and / or have a causal role in colorectal carcinogenesis [57]; however, it is not enough in the literature to conclude that HPV is a causative agent of colorectal cancer [55][56] as in CaCu [5,[25][26][27][28][29][30][31][32]; HPV has also been detected in precursor lesions of colorectal cancer [6,[57][58][59][60][61][62][63].…”

Section: Discussionmentioning

confidence: 99%

“…HPVs are classified as high or low risk. Infections with low-risk genotypes are generally self-limited and do not lead to malignancy, HPV-ar infections (HPV- 16,18,31,33,35,39,45,51,52,55,56,58, genotypes 59, 68, 73, 82 and 83) are associated with the development of cancers where 96% are positive for HPV-ar, mainly for cervical cancer [6,[29][30].…”

Section: Introductionmentioning

confidence: 99%

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Virus Infection of The Human Papiloma And Its Association With Colorectal Cancer

Hernánde¹

2020

JCRR

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Colorectal cancer is the third most common cancer in men and women worldwide; its carcinogenesis is a complex multi-step process that involves environmental factors, lifestyle, genetic mutation and viral infections; Human papillomavirus (HPV) infection plays a crucial role in human carcinomas, mainly anogenital and oropharyngeal; HPV is a prognostic factor since it is associated with vascular invasion, ganglionic metastases and tumor size; HPV is reported to be present in 70% of colorectal cancers and HPV-16 E6 / E7 oncoproteins are involved in carcinogenesis, including colorectal cancer; prevention with HPV vaccines can prevent some cancers including colorectal cancer. The link between HPV and colorectal cancer became evident, without distinction between the sexes, with similar values between HPV 16 and HPV 18. Studies are needed to investigate the relationship between HPV and colorectal cancer.

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“…[5][6][7][8][9] HPV infection is associated with benign and malignant diseases such as condyloma acuminatum and respiratory papillomatosis (laryngeal papillomatosis), as well as gastrointestinal, cervical, anal, vulval, vaginal, penile, and head and neck cancers. [10][11][12][13] A high-risk (HR) HPV type (e.g., type 16 or type 18) is likely to cause cervical cell abnormalities that may eventually lead to cancer. 14,15 HR-HPVs were divided into 14 types presented by the CDC, and the remaining types were identified as low-risk (LR) HPVs.…”

Section: Introductionmentioning

confidence: 99%

Next‐generation sequencing for typing human papillomaviruses and predicting multi‐infections and their clinical symptoms

Kim

Hwang

Ann

et al. 2021

Microbiology and Immunology

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Human papillomavirus (HPV) has more than 100 different types, some of which are associated with cancer. The most common example is that of cervical cancer, which is associated with HPV16 and HPV18. Here, we performed next-generation sequencing (NGS) to type 2436 samples obtained from Korean women to elucidate the correlation between multiple infections, virus types, and cytology. NGS revealed that types 58, 56, and 16 were the most common in high-risk (HR) types, whereas types 90, 54, and 81 were the most common in low-risk (LR) types. The incidence of atypical squamous cells of undetermined significance (ASCUS) or high-grade squamous intraepithelial lesion (HSIL) was 11.45% in single-type cases and 27.17% in multiple infections by the two types of HPV. ASCUS or HSIL was 29.79% in only the HR type multiple infections and 29.81% in mixed high-and low-risk types of multiple infections, whereas it was 18.79% in LR type multiple infections (P ≤ 0.0001). Co-infection by LR-HPV and HR-HPV is therefore more likely to cause cell lesions. Collectively, these results show that the higher the incidence of multiple infections, the greater the frequency of cell lesions. Thus, to predict the clinical symptoms, it would be beneficial to confirm the HPV type and multiple infections using NGS, although this could be relatively expensive.

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Frequency of human papillomavirus infection in patients with gastrointestinal cancer

Cited by 8 publications

References 20 publications

Involvement of HHV-4 (Epstein–Barr Virus) and HHV-5 (Cytomegalovirus) in Inflammatory Bowel Disease and Colorectal Cancer: A Meta-Analysis

Involvement of HHV-4 (Epstein–Barr Virus) and HHV-5 (Cytomegalovirus) in Inflammatory Bowel Disease and Colorectal Cancer: A Meta-Analysis

Virus Infection of The Human Papiloma And Its Association With Colorectal Cancer

Next‐generation sequencing for typing human papillomaviruses and predicting multi‐infections and their clinical symptoms

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