Frequency of polymorphisms of genes coding for HIV-1 co-receptors CCR5 and CCR2 in a Brazilian population

Munerato, Patrı́cia; Azevedo, Maria Lúcia; Sucupira, Maria Cecília Araripe; Pardini, Regina; Pinto, Gedson H. Novaes; Catroxo, Márcia Helena Braga; Souza, Inara E.; Diaz, Ricardo Sobhie

doi:10.1590/s1413-86702003000400002

Cited by 29 publications

(24 citation statements)

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“…Another study in the Southeast found an allele frequency of 8.15%. These data are similar to those found in North America and Western europe (Munerato et al 2003).…”

Section: Discussionsupporting

confidence: 90%

“…The CCR5-∆32 allele has been found in Brazilian populations in frequencies between 2.2-6.8% (Munerato et al 2003, Vargas et al 2006, Reiche et al 2008, Rigatto et al 2008. Here, we found a frequency of 2.4%.…”

Section: Discussionsupporting

confidence: 51%

“…The Brazilian population presents a complex genetic background, characterised by a high degree of miscegenation (Callegari-Jacques et al 2003, Pena 2005. In major Brazilian cities, CCR5-∆32 was found at frequencies of between 2-7% (Munerato et al 2003, Vargas et al 2006, Reiche et al 2008, Rigato et al 2008, CCR5-59029A between 39-44% (Rigato et al 2008), CCR2-64I at approximately 10% (Munerato et al 2003, Rigato et al 2008) and SDF1-3'A between 18-22% (Reiche et al 2006, Rigato et al 2008. Despite the moderate rates of HIV infection reported in Brazil, little is known about the influence of genetic polymorphisms on HIV disease progression in this population.…”

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confidence: 96%

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The effect of combined polymorphisms in chemokines and chemokine receptors on the clinical course of HIV-1 infection in a Brazilian population

Vieira

Barral

Mendoza-Sassi

et al. 2011

Mem. Inst. Oswaldo Cruz

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“…Another study in the Southeast found an allele frequency of 8.15%. These data are similar to those found in North America and Western europe (Munerato et al 2003).…”

Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 51%

mentioning

confidence: 96%

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The effect of combined polymorphisms in chemokines and chemokine receptors on the clinical course of HIV-1 infection in a Brazilian population

Vieira

Barral

Mendoza-Sassi

et al. 2011

Mem. Inst. Oswaldo Cruz

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“…Outside Europe, the mutation is found in populations of European descent. In Brazilian urban populations (HIV serological status not determined) the CCR5 variant has been found with frequencies between 0.030 and 0.065 (Passos and Picanço, 1998;Pereira et al, 2000;Munerato et al, 2003;Carvalhaes et al, 2004). This mutation is rare in Afro-Brazilians communities (0.008) and absent in Brazilian Amerindians (Leboute et al, 1999;Su et al, 2000;Grimaldi et al, 2002;Carvalhaes et al, 2004).…”

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confidence: 99%

“…The absence of significant differences in the allelic and genotypic frequencies between HIV-1 seropositive and seronegative individuals has also been reported in other Brazilian populations. Grimaldi et al (2002) reported such a lack of difference for the population of Salvador, the capital of the Brazilian state of Bahia, total population estimated at 2,631,831 (IBGE, 2004) and Munerato et al (2003) in the population of Brazilian city of São Paulo, the largest Brazilian city with a population of about 11 million (IBGE, 2004).…”

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Frequencies of CCR5-D32, CCR2-64I and SDF1-3’A mutations in Human Immunodeficiency Virus (HIV) seropositive subjects and seronegative individuals from the state of Pará in Brazilian Amazonia

et al. 2005

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The distribution of genetic polymorphisms of chemokine receptors CCR5-D32, CCR2-64I and chemokine (SDF1-3'A) mutations were studied in 110 Human Immunodeficiency Virus type 1 (HIV-1) seropositive individuals (seropositive group) and 139 seronegative individuals (seronegative group) from the population of the northern Brazilian city of Belém which is the capital of the state of Pará in the Brazilian Amazon. The CCR5-D32 mutation was found in the two groups at similar frequencies, i.e. 2.2% for the seronegative group and 2.7% for the seropositive group. The frequencies of the SDF1-3'A mutation were 21.0% for the seronegative group and 15.4% for the seropositive group, and the CCR2-64I allele was found at frequencies of 12.5% for the seronegative group and 5.4% for the seropositive group. Genotype distributions were consistent with Hardy-Weinberg expectations in both groups, suggesting that none of the three mutations has a detectable selective effect. Difference in the allelic and genotypic frequencies was statistically significant for the CCR2 locus, the frequency in the seronegative group being twice that found in the seropositive group. This finding may indicate a protective effect of the CCR2-64I mutation in relation to HIV transmission. However, considering that the CCR2-64I mutation has been more strongly associated with a decreased risk for progression for AIDS than to the resistance to the HIV infection, this could reflect an aspect of population structure or a Type I error.

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Chemokine Receptors and NeuroAIDS

Meucci¹

2010

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), except for brief excerpts in connection with reviews or scholarly analysis. Use in connection with any form of information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed is forbidden. The use in this publication of trade names, trademarks, service marks, and similar terms, even if they are not identified as such, is not to be taken as an expression of opinion as to whether or not they are subject to proprietary rights.Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com) PrefaceThis is a remarkably timely volume for several distinct reasons. First, it captures an inflection point in the neurological consequences of the HIV pandemic. With the widespread use of highly active anti-retroviral therapy (HAART), devastating syndromes of HIV-associated dementia and vacuolar myelopathy have given way, respectively, to milder complications including cognitive impairment and painful peripheral neuropathy. The present book addresses mechanisms of these contemporary disorders. Second, there is an extensive discussion of pathways by which HIV infection, or its treatment, can lead to pain. Chemokines and their receptors constitute an integral part of this process, and this book contains the largest compilation to date, of concentrated information about the implication of chemokine biology in pain. Lastly, the book addresses chemokine receptor CXCR4 from multiple perspectives. This receptor and CXCL12, its ligand, participate in virtually every phase of biology from development, through organization and deployment of immune and nervous-system elements, infection, immunity, neurophysiology, adult neurogenesis, and functions of numerous tissue stem cells. The combination of these varied unique emphases renders this book highly topical.Beginning Sect. I, Kolson and colleagues provide a measured consideration of a wide variety of research methods from magnetic resonance spectroscopy (MRS) to analysis of HIV proteins in in vitro systems. Fischer-Smith and Rappaport treat several overlapping topics, in effect yielding a "second opinion" about how to apply current research methods in the study of HIV-related neurological disease. Tan, Hoke, and Nath effectively and forcefully integrate clinical and pathogenetic data related to the crucial topic of HIV disease and peripheral neuropathy. Wigdahl's group contributes an authoritative and accessible treatment of HIV-viral latency embellished with well-designed graphics to illustrate complex concepts. Klein and coworkers combine a lucid review of chemokine receptors responsible for leukocyte trafficking with the presentation of a novel hypothesis, drawn from their research, about the role of CXCL12/CXCR4 as organizers of CNS perivascular infiltrates.Section II opens with a fascinating discussion by Vergote, Overall, and Power on how proteolytic cleavage of CXCL12 by MMP2 mediates neurotoxicity via an aberrant ligand-receptor interaction with CXCR3. R...

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Frequency of polymorphisms of genes coding for HIV-1 co-receptors CCR5 and CCR2 in a Brazilian population

Abstract: Entry of human immunodeficiency type 1 virus (HIV-1) into target cells requires both CD

Cited by 29 publications

References 20 publications

The effect of combined polymorphisms in chemokines and chemokine receptors on the clinical course of HIV-1 infection in a Brazilian population

The effect of combined polymorphisms in chemokines and chemokine receptors on the clinical course of HIV-1 infection in a Brazilian population

Frequencies of CCR5-D32, CCR2-64I and SDF1-3’A mutations in Human Immunodeficiency Virus (HIV) seropositive subjects and seronegative individuals from the state of Pará in Brazilian Amazonia

Chemokine Receptors and NeuroAIDS

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