Frequency of Reactivity for <i>Porphyromonas gingivalis</i> and <i>Prevotella</i> spp. in Supraand Subgingival Plaques, and Periodontal Clinical Parameters According to Subject Age

Tanaka, Shoji; Murakami, Yukio; Ogiwara, Takako; Shoji, Masao; Seto, Kazuhito; Nagasaki, Masahumi; Fujisawa, Seiichiro

doi:10.1902/jop.2002.73.8.877

Cited by 16 publications

(15 citation statements)

References 37 publications

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“…As epidemiological data support that incidence of periodontal disease increases with age [18,19], and our data using wild type Pg indicated that BMM from aged mice displayed an overall trend of reduced ability to produce immune mediators as compared to that of young mice. We speculated that one possibility for the increased incidence of periodontal disease in aged populations may reflect the reduced function of immune response and an attenuated strain of Pg can induce immune response similar to a virulent Pg strain.…”

Section: Resultssupporting

confidence: 72%

“…Periodontal disease is increasingly more common in adults as they age, suggesting that aging influences periodontal disease [18,19,50,51]. Despite this clear epidemiological connection, the mechanisms underlying aging and increased incidence/progression of periodontal disease are poorly understood; however, inflammatory response contributes significantly to periodontitis-associated tissue destruction.…”

Section: Discussionmentioning

confidence: 99%

“…Epidemiological data from humans has shown Pg in the oral cavity of young adults (20-30 years of age), however clinical onset of periodontal disease is not commonly identified until the 3-4 decade of life. Susceptibility to this disease increases with age [18,19]. Despite evidence supporting early acquisition of Pg and other periodontal pathogens to the oral microflora [18], why adults show onset of periodontal disease later in life is not clearly understood.…”

Section: Introductionmentioning

confidence: 99%

“…Susceptibility to this disease increases with age [18,19]. Despite evidence supporting early acquisition of Pg and other periodontal pathogens to the oral microflora [18], why adults show onset of periodontal disease later in life is not clearly understood. Employing a macrophage challenge model, in the present study we were interested to determine if the innate immune response to Pg is affected by host age.…”

Section: Introductionmentioning

confidence: 99%

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Immune response of macrophages from young and aged mice to the oral pathogenic bacterium Porphyromonas gingivalis

Shaik‐Dasthagirisaheb

Kantarcı

Gibson

2010

Immun Ageing

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Periodontal disease is a chronic inflammatory gum disease that in severe cases leads to tooth loss. Porphyromonas gingivalis (Pg) is a bacterium closely associated with generalized forms of periodontal disease. Clinical onset of generalized periodontal disease commonly presents in individuals over the age of 40. Little is known regarding the effect of aging on inflammation associated with periodontal disease. In the present study we examined the immune response of bone marrow derived macrophages (BMM) from young (2-months) and aged (1-year and 2-years) mice to Pg strain 381. Pg induced robust expression of cytokines; tumor necrosis factor (TNF)-α, interleukin (IL)-6, and IL-10, chemokines; neutrophil chemoattractant protein (KC), macrophage colony stimulating factor (MCP)-1, macrophage inflammatory protein (MIP)-1α and regulated upon activation normal T cell expressed and secreted (RANTES), as well as nitric oxide (NO, measured as nitrite), and prostaglandin E2 (PGE2) from BMM of young mice. BMM from the 2-year age group produced significantly less TNF-α, IL-6 and NO in response to Pg as compared with BMM from 2-months and 1-year of age. We did not observe any difference in the levels of IL-1β, IL-10 and PGE2 produced by BMM in response to Pg. BMM from 2-months and 1-year of age produced similar levels of all chemokines measured with the exception of MCP-1, which was reduced in BMM from 1-year of age. BMM from the 2-year group produced significantly less MCP-1 and MIP-1α compared with 2-months and 1-year age groups. No difference in RANTES production was observed between age groups. Employing a Pg attenuated mutant, deficient in major fimbriae (Pg DPG3), we observed reduced ability of the mutant to stimulate inflammatory mediator expression from BMMs as compared to Pg 381, irrespective of age. Taken together these results support senescence as an important facet of the reduced immunological response observed by BMM of aged host to the periodontal pathogen Pg.

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Section: Resultssupporting

confidence: 72%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Immune response of macrophages from young and aged mice to the oral pathogenic bacterium Porphyromonas gingivalis

Shaik‐Dasthagirisaheb

Kantarcı

Gibson

2010

Immun Ageing

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“…There are few studies, however, that examine microbial colonization and gingival health during childhood in healthy populations 12 . Thus, the relationship between clinical parameters such as gingival index (GI) and the distribution of several periodontal pathogens in children is not yet well understood 13 .…”

Section: Introductionmentioning

confidence: 99%

Prevalence of four putative periodontopathic bacteria in saliva of a group of Brazilian children with mixed dentition: 1‐year longitudinal study

Sakai¹,

Campos

Machado³

et al. 2007

Int J Paed Dentistry

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A retrospective analysis of the role of age and sex in outcomes of non-surgical periodontal therapy at a single academic dental center

Angelov,

Soldatos,

Ioannidou

et al. 2024

Sci Rep

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The present study examined the role of age and sex in the outcomes of non-surgical periodontal therapy (NSPT). De-identified demographic and periodontal characteristics of patients who presented for baseline periodontal evaluation, NSPT, and periodontal re-evaluation were abstracted from electronic health records. Independent associations of age and sex with severe periodontitis defined as ≥ 5 mm clinical attachment loss (CAL) and ≥ 6 mm probing depth (PD) were determined using multinomial logistic regression. The null hypothesis was rejected at α < 0.05. A total of 2866 eligible subjects were included in the analysis. Significantly lower odds of CAL ≤ 4 mm than CAL ≥ 5 mm (reference) were observed in adults aged 35–64 (odds ratio, OR, 0.19; 95% confidence interval, CI 0.13, 0.29) and ≥ 65 years (OR 0.13; 95% CI 0.07, 0.25) compared to those aged 18–34 years. Odds of PD < 4 mm versus PD ≥ 6 mm (reference) were lower in adults aged 35–64 years than those aged 18–34 years (OR 0.71; 95% CI 0.55, 0.90) and higher in females compared to males (OR 1.67; 95% CI 1.14, 2.44). These results suggest more compromised post-NSPT outcomes in older adults and males compared to the respective populations and highlight the need for personalized therapeutic strategies in these populations.

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Frequency of Reactivity for Porphyromonas gingivalis and Prevotella spp. in Supraand Subgingival Plaques, and Periodontal Clinical Parameters According to Subject Age

Cited by 16 publications

References 37 publications

Immune response of macrophages from young and aged mice to the oral pathogenic bacterium Porphyromonas gingivalis

Immune response of macrophages from young and aged mice to the oral pathogenic bacterium Porphyromonas gingivalis

Prevalence of four putative periodontopathic bacteria in saliva of a group of Brazilian children with mixed dentition: 1‐year longitudinal study

A retrospective analysis of the role of age and sex in outcomes of non-surgical periodontal therapy at a single academic dental center

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