Frequency of Sexual Dysfunction in Patients with a Psychotic Disorder Receiving Antipsychotics

Montejo, Ángel L.; Majadas, S.; Rico‐Villademoros, Fernando; Llorca, G; Gándara, Jesús de la; Franco, Manuel; Martı́n-Carrasco, Manuel; Agüera, L.; Prieto, N.

doi:10.1111/j.1743-6109.2010.01709.x

Cited by 107 publications

(67 citation statements)

References 39 publications

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“…Sexual dysfunction tends to be under-estimated in psychotic patients, for several reasons including lack of confidence in health providers, shame, cultural difficulties and lack of interest by psychiatrists. The extent of sub-optimal communication about sexuality in patients with a psychotic disorder assessed within routine clinical practice is considerable, affecting 50-73% of those with sexual dysfunction 13 . Lack of adequate discussion is more common in female patients, of whom 80% reported not to have discussed sexual function with their mental health care providers 27 , and the Psychotropic-Related Sexual Dysfunction Questionnaire (PRSexDQ-SALSEX) 32 were found to address all aspects of sexual functioning, making them preferable for clinical practice and research 33 .…”

Section: Influence Of Treatment Of Psychosis On Sexualitymentioning

confidence: 99%

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The impact of severe mental disorders and psychotropic medications on sexual health and its implications for clinical management

2018

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Sexual dysfunction often accompanies severe psychiatric illness and can be due to both the mental disorder itself and the use of psychotropic treatments. Many sexual symptoms resolve as the mental state improves, but treatment-related sexual adverse events tend to persist over time, and are unfortunately under-recognized by clinicians and scarcely investigated in clinical trials. Treatment-emergent sexual dysfunction adversely affects quality of life and may contribute to reduce treatment adherence. There are important differences between the various compounds in the incidence of adverse sexual effects, associated with differences in mechanisms of action. Antidepressants with a predominantly serotonergic activity, antipsychotics likely to induce hyperprolactinaemia, and mood stabilizers with hormonal effects are often linked to moderate or severe sexual dysfunction, including decreased libido, delayed orgasm, anorgasmia, and sexual arousal difficulties. Severe mental disorders can interfere with sexual function and satisfaction, while patients wish to preserve a previously satisfactory sexual activity. In many patients, a lack of intimate relationships and chronic deterioration in mental and physical health can be accompanied by either a poor sexual life or a more frequent risky sexual behaviour than in the general population. Here we describe the influence of psychosis and antipsychotic medications, of depression and antidepressant drugs, and of bipolar disorder and mood stabilizers on sexual health, and the optimal management of patients with severe psychiatric illness and sexual dysfunction.

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Section: Influence Of Treatment Of Psychosis On Sexualitymentioning

confidence: 99%

“…Depending on the measurement method, it affects between 38 and 86% of patients [10][11][12][13] , including remitted ones and those experiencing a first episode of schizophrenia 14,15 .…”

Section: Influence Of Treatment Of Psychosis On Sexualitymentioning

confidence: 99%

The impact of severe mental disorders and psychotropic medications on sexual health and its implications for clinical management

2018

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“…Desire is difficult to quantify because it also depends on many intra-and interindividual as well as environmental dynamics, including the physical and emotional health of both sexual partners, their chronological age, length of their relationship (monotony of sexual behavior), and medications (particularly hormones, antipsychotics, and antidepressants) [6]. Excluding these factors, maintenance of an adequate level of sexual interest does not require an excessive amount of gonadal steroids.…”

Section: Central Effectsmentioning

confidence: 99%

Androgens are Fundamental in the Maintenance of Male Sexual Health

Morales

2011

Curr Urol Rep

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The presence of a sufficient amount of androgens is essential for adequate sexual function in men. Gonadal hormones profoundly affect cognitive functions and, therefore, are fundamental in maintaining sexual desire. The earliest manifestation of hypogonadism is diminished libido. Furthermore, androgens also act peripherally, maintaining the integrity of penile structures and facilitating the erectile mechanisms. Severe androgen deficiency results in anatomical and hemodynamic changes leading to erectile dysfunction that can be corrected with testosterone supplementation.

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“…The adverse effects of antipsychotic drugs, however, directly influence patient health-related quality of life (HRQoL) [4] and might also affect their adherence to treatment. Antipsychotic drugϪrelated sexual dysfunction was recently linked, for instance, to poor compliance in 36% of males and 20% of females diagnosed with schizophrenia [5].…”

Section: Introductionmentioning

confidence: 99%

Estimation of a Multiattribute Utility Function for the Spanish Version of the TooL Questionnaire

et al. 2011

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Frequency of Sexual Dysfunction in Patients with a Psychotic Disorder Receiving Antipsychotics

Cited by 107 publications

References 39 publications

The impact of severe mental disorders and psychotropic medications on sexual health and its implications for clinical management

The impact of severe mental disorders and psychotropic medications on sexual health and its implications for clinical management

Androgens are Fundamental in the Maintenance of Male Sexual Health

Estimation of a Multiattribute Utility Function for the Spanish Version of the TooL Questionnaire

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