Frequency ofBCL-2/JH translocations in peripheral blood of follicular lymphoma patients

Abstract

Polymerase chain reaction (PCR) assays have been developed for follicular lymphomaassociated BCL-2/J H translocations. Few data are available on the quantitation by PCR of these translocations in peripheral blood mononuclear cells (PBM) of follicular lymphoma (FL) patients. We report that only one of five studied FL patients had a high level of these translocations in the circulation, namely, about 35,000 translocations per 5 × 10 6 PBM. This patient was stable with an excellent performance status at the time of this assay; however, he died of leukemia 1 month later. Am.

Mouse homologue of HOS (mHOS) is overexpressed in skin tumors and implicated in constitutive activation of NF-κB

“…Various human cancers demonstrate up-regulated NF-kB activities. Members of the NF-kB and IkB families are associated with chromosomal translocations in certain lymphomas (Zhang et al, 1997). There is growing evidence that the regulation of IkB and modulation of NF-kB activity may play an important role in controlling cellular proliferation.…”