Frequency-Selective Coding of Translation and Tilt in Macaque Cerebellar Nodulus and Uvula

Yakusheva, Tatyana A.; Blazquez, Pablo M.; Angelaki, Dora E.

doi:10.1523/jneurosci.2232-08.2008

Cited by 54 publications

(112 citation statements)

References 69 publications

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“…The present findings on the defective explorative activity of the HCbed animals are in agreement with the general framework that considers the cerebellar structures heavily involved in processing motor performance-related signals [33]. In fact, in the knowledge of motion through space, the cerebellar circuits are implicated in acquiring information necessary for spatial orientation, self-motion perception, and postural control [34][35][36].…”

Section: Discussionsupporting

confidence: 89%

Cerebellar Damage Loosens the Strategic Use of the Spatial Structure of the Search Space

et al. 2009

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The influence of a hemicerebellar lesion on the exploration of environments with different spatial distributions of multiple rewards was analyzed. Hemicerebellectomized (HCbed) and intact rats were submitted to a search task in which they had to explore nine food trays in an open field, avoiding repeated visits. Trays were spatially arranged in four configurations: cross, 3 x 3 matrix, circle, and three clusters of three trays each. Lesioned and intact rats' performances improved in all configurations used. However, the explorative activity of the HCbed animals differed from that of intact rats. Lesioned animals spent more time, made more errors, displayed lower search efficiency, exhibited shorter final spans, and traveled longer distances. They tended to perseverate and to neglect some trays. The cerebellar damage differentially influenced performances as a specific effect of the susceptibility of the configurations to being explored in a principled way. In the cross configuration that had strong spatial constraints, both groups made their lowest number of errors. In the circle configuration, the altered explorative strategies of lesioned animals made extremely demanding the acquisition of the task of searching multiple rewards, in spite of the attempt of favoring their altered procedures through an appropriate spatial arrangement. Since the procedural impairment elicited by cerebellar damage affected the central exploration, the matrix configuration was the most difficult configuration to be explored by the HCbed rats. The poor performances in the cluster configuration indicated that chunking was a strategy of relative strength in rats in general and in HCbed rats in particular.

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Section: Discussionsupporting

confidence: 89%

Cerebellar Damage Loosens the Strategic Use of the Spatial Structure of the Search Space

et al. 2009

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“…Whether the rVA and rHA zones seen in the marmoset also span a ZIIϩ/Ϫ stripe, as in birds, has yet to be determined. The uvula/nodulus in birds and mammals is functionally similar insofar as it is involved in selftranslation Barmack and Shojaku, 1995;Yakusheva et al, 2008). In both birds and mammals, the nodulus is uniformly ZIIϩ, while the uvula contains a number of alternating ZIIϩ/Ϫ stripes in all species investigated (Hawkes and Herrup, 1995;Pakan et al, 2007;Marzban and Hawkes, 2011).…”

Section: The Utility Of the Vestibulocerebellum As A General Model Fomentioning

confidence: 99%

Zebrin-Immunopositive and -Immunonegative Stripe Pairs Represent Functional Units in the Pigeon Vestibulocerebellum

Graham

Wylie

2012

J. Neurosci.

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The cerebellum is a site of complex sensorimotor integration and contains up to 80% of the neurons in the brain, yet comparatively little is known about the organization of sensorimotor systems within the cerebellum. It is known that afferent projections and Purkinje cell (PC) response properties are organized into sagittal "zones" in the cerebellum. Moreover, the isoenzyme aldolase C [also known as zebrin II (ZII)] is heterogeneously expressed in cerebellar PCs such that there are sagittal stripes of PCs with high expression (ZIIϩ) interdigitated with stripes of little or no expression (ZIIϪ). In the present study, we show how the ZII stripes in folium IXcd of the vestibulocerebellum in pigeons are related to response properties of PCs. IXcd consists of seven pairs of ZIIϩ/Ϫ stripes denoted P1ϩ/Ϫ (medial) to P7ϩ/Ϫ (lateral). Electrophysiological studies have shown that vestibulocerebellar PCs respond to particular patterns of optic flow resulting from self-motion in three-dimensional space. In our study, we recorded optic flow preferences from PCs in IXcd, marked recording locations with injections of fluorescent tracer, and subsequently immunoreacted coronal sections for ZII. We found that the PCs within a ZIIϩ/Ϫ stripe pair all responded best to the same pattern of optic flow. That is, a ZIIϩ/Ϫ stripe pair forms a functional unit in the cerebellum. This is the first demonstration that the function of PCs is associated with ZII stripes across the mediolateral extent of an entire folium.

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“…Subsequently, inertial-driven, pure translation signals are isolated by subtracting tilt-only signals from the undifferentiated otolith afferent-like signals. Recent reports suggest that independent tilt and translation-related signals are present in vestibular nuclei and cerebellar uvula-nodulus Yakusheva et al 2008;Zhou et al 2006).…”

Section: Compensatory Lvor Versus Orienting Ocular Responsesmentioning

confidence: 99%

Frequency-Dependent Spatiotemporal Tuning Properties of Non–Eye Movement Related Vestibular Neurons to Three-Dimensional Translations in Squirrel Monkeys

Chen-Huang

Peterson

2010

Journal of Neurophysiology

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Chen-Huang C, Peterson BW. Frequency-dependent spatiotemporal tuning properties of non-eye movement related vestibular neurons to threedimensional translations in squirrel monkeys. J Neurophysiol 103: 3219-3237, 2010. First published April 7, 2010 doi:10.1152/jn.00904.2009. Responses of vestibular-only translation sensitive (VOTS) neurons in vestibular nuclei of two squirrel monkeys were studied at multiple frequencies to three-dimensional translations and rotations. A novel frequency-dependent spatiotemporal analysis examined in each neuron whether complex models, with unrestricted response dynamics in three-dimensional (3D) space, provided significantly better fits than restricted models following simple, cosine rule. Subsequently, the statistically selected optimal model was used to predict the maximum translation direction, expressed as a unitary vector, Vt max , and its associated sensitivity and phase across frequencies. Simple models were sufficient to quantify the 3D translational responses of 66% of neurons. Most VOTS neurons, complex or simple, exhibited flat-gain or low-pass response dynamics. The Vt max of simple neurons was fixed, whereas that of complex neurons changed with frequency. The spatial distribution of Vt max in simple neurons, which fell within 30°o f either the horizontal plane or/and the sagittal plane, was closely aligned with Vt max of vestibular afferents. In contrast, the frequencydependent Vt max of most complex neurons migrated from the dorsoventral axis at higher frequency toward the horizontal plane, especially the interaural axis, at lower frequency. When the maximum rotation direction was estimated from responses of the same VOTS neurons to 1.2 Hz yaw, pitch, and roll rotations, complex neurons were more likely to respond to rotations activating vertical canals. Responses to 0.15-0.3 Hz linear accelerations produced by inertial or gravitational forces were indistinguishable in most complex neurons but significantly different in most simple neurons. These observations suggest that simple and complex VOTS neurons constitute distinctive vestibular pathways where complex neurons, exhibiting a novel spatiotemporal filtering mechanism in processing otolith-related signals, are well suited to drive tilt-related responses, whereas simple neurons probably mediate pure translation related responses.

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Frequency-Selective Coding of Translation and Tilt in Macaque Cerebellar Nodulus and Uvula

Cited by 54 publications

References 69 publications

Cerebellar Damage Loosens the Strategic Use of the Spatial Structure of the Search Space

Cerebellar Damage Loosens the Strategic Use of the Spatial Structure of the Search Space

Zebrin-Immunopositive and -Immunonegative Stripe Pairs Represent Functional Units in the Pigeon Vestibulocerebellum

Frequency-Dependent Spatiotemporal Tuning Properties of Non–Eye Movement Related Vestibular Neurons to Three-Dimensional Translations in Squirrel Monkeys

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