Frequency, type, distribution of pain and related factors in persons with multiple sclerosis,

Kahraman, Turhan; Özdoğar, Asiye Tuba; Ertekin, Özge; Özakbaş, Serkan

doi:10.1016/j.msard.2019.01.002

Cited by 25 publications

(26 citation statements)

References 34 publications

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“…Solaro et al claim that neuropathic pain is strongly associated with the disease severity 36 and people with musculoskeletal pain seems to have lower Expanded Disability Status Scale 39 scores. 32 In contrast, other studies reported no relationships between having older age 5,8,27,28 and longer disease duration. 4,8,18,27 Gender is a conflicting risk factor since some studies found no difference between females and males, 4,8,24,28,38 while other studies found a difference.…”

Section: Possible Risk Factors For Developing Pain In Msmentioning

confidence: 95%

“…23,30,31 In case the pain is neuropathic, the degree of interference increases, especially in terms of depression. 26,32 However, Day et al 33 suggest that the association between pain and depression is exaggerated throughout the past studies, because when the severity of MS symptoms reduced, the association between pain and depression becomes controlled.…”

Section: Impacts Of Pain In Msmentioning

confidence: 99%

“…6,8,27,28 Lower education level was mentioned as a risk factor of MS pain; 6,33 however, this was not confirmed in another recent study. 32 In addition, an association between lower socioeconomic and marital status and pain intensity is found. 33 In future, taking the type of pain (neuropathic or nociceptive) into account when reporting risk factors may be more indicative.…”

Section: Introduction To Painmentioning

confidence: 97%

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Clinical perspective on pain in multiple sclerosis

et al. 2020

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Pain is an important and frequent symptom in multiple sclerosis (MS), which leads to a low quality of life, increased disability level, and lack of employment and mental health. Recently, studies have shown increased interest in pain in MS and there is a growing evidence of its prevalence. However, the literature suffers from lack of experimental studies focusing on pain reduction. This topical review summarizes the current knowledge about pain in MS with its definitions, assessments, treatments and rehabilitation within a holistic perspective.

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Section: Possible Risk Factors For Developing Pain In Msmentioning

confidence: 95%

Section: Impacts Of Pain In Msmentioning

confidence: 99%

Section: Introduction To Painmentioning

confidence: 97%

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Clinical perspective on pain in multiple sclerosis

et al. 2020

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“…Most of the MS related symptoms have separately been associated with impaired QoL in previous studies, including pain [ 9 ], spasticity [ 10 ] and fatigue [ 11 ]. However, the studies have reported inconsistent results when examining the association between disability, primarily addressed by the Expanded Disability Status Scale (EDSS) score, and QoL.…”

Section: Introductionmentioning

confidence: 99%

The association of selected multiple sclerosis symptoms with disability and quality of life: a large Danish self-report survey

et al. 2021

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Background People with multiple sclerosis (MS) experience a wide range of unpredictable and variable symptoms. The symptomatology of MS has previously been reported in large sample registry studies; however, some symptoms may be underreported in registries based on clinician-reported outcomes and how the symptoms are associated with quality of life (QoL) are often not addressed. The aim of this study was to comprehensively evaluate the frequency of selected MS related symptoms and their associations with disability and QoL in a large self-report study. Methods We conducted a cross-sectional questionnaire survey among all patients at the Danish Multiple Sclerosis Center, Copenhagen University Hospital, Denmark. The questionnaire included information on clinical and sociodemographic characteristics, descriptors of QoL and disability, as well as prevalence and severity of the following MS symptoms: impaired ambulation, spasticity, chronic pain, fatigue, bowel and bladder dysfunction, and sleep disturbances. Results Questionnaires were returned by 2244/3606 (62%). Participants without MS diagnosis or incomplete questionnaires were excluded, n = 235. A total of 2009 questionnaires were included for analysis (mean age 49.4 years; mean disease duration 11.7 years; and 69% were women). The most frequently reported symptoms were bowel and bladder dysfunction (74%), fatigue (66%), sleep disturbances (59%), spasticity (51%) and impaired ambulation (38%). With exception of fatigue and sleep disturbances, all other symptoms increased in severity with higher disability level. Invisible symptoms (also referred to as hidden symptoms) such as fatigue, pain and sleep disturbances had the strongest associations with the overall QoL. Conclusion We found invisible symptoms highly prevalent, even at mild disability levels. Fatigue, pain and sleep disturbances had the strongest associations with the overall QoL and were more frequently reported in our study compared with previous registry-based studies. These symptoms may be underreported in registries based on clinician reported outcomes, which emphasizes the importance of including standardized patient reported outcomes in nationwide registries to better understand the impact of the symptom burden in MS.

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“…Interoceptive exposure is another component of the unified protocol. PwMS are more sensitive to visceral sensations than healthy individuals [ 64 ]. Dysfunctions in interoceptive inference could underlie a range of pathologies such as anxiety [ 65 ].…”

Section: Discussionmentioning

confidence: 99%

Transdiagnostic treatment of emotional disorders in people with multiple sclerosis: randomized controlled trial

et al. 2020

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Background Multiple sclerosis (MS) is a neurodegenerative disease of the central nervous system. MS is significantly associated with a high rate of psychological, behavioral, and emotional consequences. Despite the frequent mental disorders, high rate of psychological comorbidities, and emotional problems in people with MS (PwMS), these conditions are often underdiagnosed and undertreated. This study aimed to examine the efficacy of a group format of the unified protocol for the transdiagnostic treatment of emotional disorders in adult PwMS associated with an emotional disorder. Methods Seventy adult PwMS were randomized using an internet-based computer system to either the unified protocol (n = 35) or treatment as usual condition. The assessment protocol included semi-structured clinical interviews and self-reports evaluating diagnostic criteria, depression, anxiety and worry symptoms, emotional dysregulation, and affectivity. Results The parametric test of analysis of covariance, followed the intent to treat analyses, revealed the unified protocol significantly changed depression symptoms (Cohen’s d = 1.9), anxiety symptoms (Cohen’s d = 2.16), worry symptoms (Cohen’s d = 1.27), emotion dysregulation (Cohen’s d = 0.44), positive affect (Cohen’s d = 1.51), and negative affect (Cohen’s d = 1.89) compared with the control group. The unified protocol also significantly improved outcome scores at the end of treatment relative to baseline (p < .001). Conclusion The findings support that the unified protocol could be an additional efficient psychological treatment for PwMS. Trial registration IRCT, number: IRCT20190711044173N1. Registered 31october 2019, https://en.irct.ir/user/trial/40779/view.

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Frequency, type, distribution of pain and related factors in persons with multiple sclerosis,

Cited by 25 publications

References 34 publications

Clinical perspective on pain in multiple sclerosis

Clinical perspective on pain in multiple sclerosis

The association of selected multiple sclerosis symptoms with disability and quality of life: a large Danish self-report survey

Transdiagnostic treatment of emotional disorders in people with multiple sclerosis: randomized controlled trial

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