Frequent loss of HLA alleles associated with copy number-neutral 6pLOH in acquired aplastic anemia

Katagiri, Takamasa; Sato‐Otsubo, Aiko; Kashiwase, Koichi; Morishima, Satoko; Sato, Yusuke; Mori, Yoshiyuki; Kato, Motohiro; Sanada, Masashi; Morishima, Yasuo; Hosokawa, Kohei; Sasaki, Yumi; Ohtake, Shigeki; Ogawa, Seishi; Nakao, Shinji

doi:10.1182/blood-2011-07-365189

Cited by 157 publications

(184 citation statements)

References 31 publications

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“…The presence of 6pLOH is thought to offer compelling evidence of CTL involvement in the development of AA. The lack of particular class I HLA alleles that present auto-antigens represents "escape" hematopoiesis by 6pLOH(+) HSCs that have survived CTL attack [9]. However, the origin of the HLA-LLs that serve as CTL targets and the clinical significance of HLA-LLs in patients with AA have not been thoroughly determined, due to the small number of patients analyzed via FCM before immunosuppressive therapy in our previous study.…”

Section: In Vivomentioning

confidence: 97%

“…Flow cytometry (FCM) can be substituted for SNP array for detection of HLA-A allele-lacking leukocytes (HLA-LLs) as a result of 6pLOH, because 6pLOH was revealed in all HLA-LL(+) patients in our previous study [9]. The presence of 6pLOH is thought to offer compelling evidence of CTL involvement in the development of AA.…”

Section: In Vivomentioning

confidence: 99%

“…Single nucleotide polymorphism (SNP) array analysis reveals the copy number-neutral loss of heterozygosity of the HLA haplotype due to uniparental disomy in the short arm of chromosome 6 (6pLOH) in approximately 13% of AA patients [8][9][10]. Flow cytometry (FCM) can be substituted for SNP array for detection of HLA-A allele-lacking leukocytes (HLA-LLs) as a result of 6pLOH, because 6pLOH was revealed in all HLA-LL(+) patients in our previous study [9].…”

Section: In Vivomentioning

confidence: 99%

“…HLA-LLs can easily be tracked using FCM with monoclonal antibodies (mAbs) specific to HLA-A alleles [9]. Studying the lineage diversity of HLA-LLs and the correlation between the presence of HLA-LLs and the response to IST may provide insight into the CTL targets responsible for the development of AA as well as the clinical significance of HLA-LLs in AA patients.…”

Section: In Vivomentioning

confidence: 99%

“…Of these, 212 were idiopathic and 10 were hepatitis-associated; 113 were assessed pre-treatment and 109 post-treatment; 92 were diagnosed with severe AA and 130 with non-severe AA ( Table 1). Eighty-four of the 222 patients were included in our previous study of 6pLOH using SNP array analysis [9]. Previous treatments included rabbit anti-thymocyte globulin (ATG, Thymoglobulin, Sanofi, Paris, France) in 47 patients, cyclosporine (CsA) alone in 59 patients, and anabolic steroids alone in three patients.…”

Section: Patientsmentioning

confidence: 99%

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Clinical significance and origin of leukocytes that lack HLA-A allele expression in patients with acquired aplastic anemia

Muto

Katagiri

Kashiwase

et al. 2016

Experimental Hematology

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Section: In Vivomentioning

confidence: 97%

Section: In Vivomentioning

confidence: 99%

Section: In Vivomentioning

confidence: 99%

Section: In Vivomentioning

confidence: 99%

Section: Patientsmentioning

confidence: 99%

See 3 more Smart Citations

Clinical significance and origin of leukocytes that lack HLA-A allele expression in patients with acquired aplastic anemia

Muto

Katagiri

Kashiwase

et al. 2016

Experimental Hematology

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Current research status of HLA in immune‐related diseases

Liu

Shao

2021

Immunity Inflam & Disease

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Human leukocyte antigen (HLA), also known as human major histocompatibility complex (MHC), is encoded by the HLA gene complex, and is currently known to have the highest gene density and the most polymorphisms among human chromosomal areas. HLA is divided into class I antigens, class II antigens, and class III antigens according to distribution and function. Classical HLA class I antigens include HLA‐A, HLA‐B, and HLA‐C; HLA class II antigens include HLA‐DP, HLA‐DQ, and HLA‐DR; nonclassical HLA class I and II molecules include HLA‐F, E, H, X, DN, DO, and DM; and others, such as complement, are class III antigens. HLA is closely related to the body's immune response, regulation, and surveillance and is of great significance in the study of autoimmune diseases, tumor immunity, organ transplantation, and reproductive immunity. HLA is an important research topic that bridges immunology and clinical diseases. With the development of research methods and technologies, there will be more discoveries and broader prospects.

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Hematopoietic stem progenitor cells with malignancy‐related gene mutations in patients with acquired aplastic anemia are characterized by the increased expression of CXCR4

Katagiri

Espinoza

Uemori

et al. 2022

eJHaem

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The phenotypic changes in hematopoietic stem progenitor cells (HSPCs) with somatic mutations of malignancy-related genes in patients with acquired aplastic anemia (AA) are poorly understood. As our initial study showed increased CXCR4 expression on HLA allele-lacking (HLA[−]) HSPCs that solely support hematopoiesis in comparison to redundant HLA(+) HSPCs in AA patients, we screened the HSPCs of patients with various types of bone marrow (BM) failure to investigate their CXCR4 expression.

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Frequent loss of HLA alleles associated with copy number-neutral 6pLOH in acquired aplastic anemia

Cited by 157 publications

References 31 publications

Clinical significance and origin of leukocytes that lack HLA-A allele expression in patients with acquired aplastic anemia

Clinical significance and origin of leukocytes that lack HLA-A allele expression in patients with acquired aplastic anemia

Current research status of HLA in immune‐related diseases

Hematopoietic stem progenitor cells with malignancy‐related gene mutations in patients with acquired aplastic anemia are characterized by the increased expression of CXCR4

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