Fresh blood units contain large potent platelets that improve hemostasis after open heart operations

Mohr, Rephael; Goor, Daniel A.; Yellin, Alon; Moshkovitz, Yaron; Shinfeld, Ami; Martinowitz, Uri

doi:10.1016/0003-4975(92)90327-z

Cited by 39 publications

(18 citation statements)

References 18 publications

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“…Plasma components stored in platelets contribute to cancer progression by releasing cytokines and growth factors such as VEGF, platelet-derived growth factor (PDGF), TGF-β and FGF [24, 25], which play important roles in regulating angiogenesis, cell survival and cell motility [20, 26]. In addition, platelets facilitate the generation of capillary-like structures by endothelial cells through integrins mediating cell-cell adhesion [27]. Second, by interacting with fibrin and tumour cells, platelets can promote the formation of platelet-fibrin-tumour cells, which plays a significant role in evading immune surveillance and enhancing tumour cell survival [28].…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of combination of preoperative platelet count and mean platelet volume in patients with resectable non-small cell lung cancer

Gao

Zhang

et al. 2017

Oncotarget

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The aim of the present study was to investigate the prognostic value of the combination of preoperative platelet count (PLT) and mean platelet volume (MPV) in patients with primary operable non-small cell lung cancer (NSCLC). We retrospectively analysed data from 546 patients with NSCLC who underwent complete resection at our institution from 2006 to 2010. Patients’ clinical characteristics and laboratory test data at initial diagnosis were collected. Both preoperative PLT and MPV (COP-MPV) were calculated on the basis of the data obtained using the recommended cut-off values of 300 × 109 L−1 and 11.0 fL, respectively. Patients with both an elevated PLT (≥300× 109 L−1) and a decreased MPV (<11.0 fL) were assigned a score of 2, and patients showing one or neither were allocated a score of 1 or 0, respectively. Multivariate analysis of the 9 clinical laboratory variables selected by univariate analysis revealed that preoperative COP-MPV was a significantly independent prognostic factor for overall survival (OS) (hazard ratio, 1.775; 95% confidence interval, 1.500–2.101; P< 0.001) and disease-free survival (DFS) (hazard ratio, 1.719; 95% confidence interval, 1.454–2.033; P< 0.001). In subgroup analyses for tumour pathological stage (I/II/IIIA) patients, we found that the level of COP-MPV was significantly associated with OS and DFS in each subgroup (P< 0.001, P< 0.001, P<0.001 for OS and P<0.001, P< 0.001, P=0.001 for DFS, respectively). In conclusion, the preoperative COP-MPV is a promising predictor of postoperative survival in patients with NSCLC and could classify these patients into three independent groups before surgery.

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Section: Discussionmentioning

confidence: 99%

Prognostic value of combination of preoperative platelet count and mean platelet volume in patients with resectable non-small cell lung cancer

Gao

Zhang

et al. 2017

Oncotarget

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“…While many authors have discussed the potential clinical benefits of FWB transfusion (1)(2)(3)(4)(13)(14)(15)(16)(17)(18), to our knowledge this is the first study documenting risks to recipients of FWB. The incidence of transfusion reactions was equal between patients who received FWB compared with patients who received only RBCs and fresh frozen plasma, and the incidence of infectious disease transmission was higher with FWB than what is currently reported for component therapy products.…”

Section: Discussionmentioning

confidence: 99%

Risks associated with fresh whole blood and red blood cell transfusions in a combat support hospital

Spinella

Perkins

Grathwohl

et al. 2007

Critical Care Medicine

134

113

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“…13,15,30 -32 FWB often used in combat hospitals, has been shown to correct dilutional coagulopathy with evidence that a single unit has the hemostatic effect of 10 units of platelets. 33,34 Additionally, one retrospective analysis cited a 39% relative risk reduction in mortality that was noted in a group of combat casualties who were given FWB.…”

Section: Discussionmentioning

confidence: 99%

The Effectiveness of a Damage Control Resuscitation Strategy for Vascular Injury in a Combat Support Hospital: Results of a Case Control Study

Fox

Gillespie

Cox

et al. 2008

Journal of Trauma: Injury, Infection &Amp; Critical Care

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Objectives:Major vascular injury is a leading cause of potentially preventable hemorrhagic death in modern combat operations. An optimal resuscitation approach for military trauma should offer both rapid hemorrhage control and early reversal of metabolic derangements. The objective of this report is to establish the use and effectiveness of a damage control resuscitation (DCR) strategy in the setting of wartime vascular injury. Methods:A retrospective two-cohort case control study was performed using the Joint Theater Trauma Registry to identify patients with an extremity vascular injury treated at two different points in time: group 1 (n ‫؍‬ 16) from April to June 2006 when DCR concepts were put into practice and group 2 (n ‫؍‬ 24) 1 year later in a period when DCR strategies were not employed.Results: Baseline demographics, injury severity, admission physiology, and operative details were similar between groups 1 and 2. Group 1 patients received more total blood products (23 vs. 12 units, p < 0.05), fresh frozen plasma (16 vs. 7 units, p < 0.01), cryoprecipitate (11 vs. 1.2 units, p < 0.05), whole blood (19% vs. 0%, p ‫؍‬ 0.06), and early recombinant factor VIIa (75% vs. 0%, p < 0.001) than group 2 patients. Group 1 patients had a more complete early physiologic recovery after vascular reconstruction (heart rate: 38 vs. 12, p < 0.001; systolic blood pressure, 39 vs. 14, p < 0.001; base deficit: 7.36 vs.2.72, p < 0.001; International Normalized Ratio, 0.3 vs. 0.1, p < 0.001). There was no significant difference in early amputation rates (group 1: 6.2% vs. group 2: 4.2%) or 7-day mortality (0% in both groups). Conclusions:This study was the first to use the Joint Theater Trauma Registry for follow-up on an established clinical practice guideline. DCR goals appear now to be met during the management of acute wartime vascular injuries with effective correction of physiologic shock. The overall impact of this resuscitation strategy on long-term outcomes such as limb salvage and mortality remains to be determined.

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Fresh blood units contain large potent platelets that improve hemostasis after open heart operations

Cited by 39 publications

References 18 publications

Prognostic value of combination of preoperative platelet count and mean platelet volume in patients with resectable non-small cell lung cancer

Prognostic value of combination of preoperative platelet count and mean platelet volume in patients with resectable non-small cell lung cancer

Risks associated with fresh whole blood and red blood cell transfusions in a combat support hospital

The Effectiveness of a Damage Control Resuscitation Strategy for Vascular Injury in a Combat Support Hospital: Results of a Case Control Study

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