Fresh cell therapy followed by fatal coma

Goebel, Hans H.; Walther, G; Meuth, Mark

doi:10.1007/bf00314028

Cited by 18 publications

(5 citation statements)

References 14 publications

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“…Although only relatively few users of CAM reported negative effects, it should not be ignored that CAM are not always necessarily harmless. Except for single case reports [20,21], there are no systematic analyses on the safety and the complication rates of most CAMs used by patients with MS. Although there is still the widespread belief that CAMs in general are harmless, this position is clearly not justified, because even vitamin supplements have been associated with complications and increased mortality [22][23][24][25][26].…”

Section: Discussionmentioning

confidence: 99%

Complementary and alternative medicine for multiple sclerosis

Schwarz

Knorr

Geiger³

et al. 2008

Mult Scler

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We analyzed characteristics, motivation, and effectiveness of complementary and alternative medicine in a large sample of people with multiple sclerosis. A 53-item survey was mailed to the members of the German Multiple Sclerosis Society, chapter of Baden-Wuerttemberg. Surveys of 1573 patients (48.5 +/- 11.7 years, 74% women, duration of illness 18.1 +/- 10.5 years) were analyzed. In comparison with conventional medicine, more patients displayed a positive attitude toward complementary and alternative medicine (44% vs 38%, P < 0.05), with 70% reporting lifetime use of at least one method. Among a wide variety of complementary and alternative medicine, diet modification (41%), Omega-3 fatty acids (37%), removal of amalgam fillings (28%), vitamins E (28%), B (36%), and C (28%), homeopathy (26%), and selenium (24%) were cited most frequently. Most respondents (69%) were satisfied with the effects of complementary and alternative medicine. Use of complementary and alternative medicine was associated with religiosity, functional independence, female sex, white-collar job, and higher education (P < 0.05). Compared with conventional therapies, complementary and alternative medicine rarely showed unwanted side effects (9% vs 59%, P < 0.00001). A total of 52% stated that the initial consultation with their physician lasted less than 15 min. To conclude, main reasons for the use of complementary and alternative medicine include the high rate of side effects and low levels of satisfaction with conventional treatments and brief patients/physicians contacts.

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Section: Discussionmentioning

confidence: 99%

Complementary and alternative medicine for multiple sclerosis

Schwarz

Knorr

Geiger³

et al. 2008

Mult Scler

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“…They also point out that the claimed benefits of this type of cell therapy have not been proven in clinical studies and there may also be negative side effects (see e.g. Goebel, Walther and Meuth, 1986;Last 1990). In fact, many countries ban the practice of fresh cell therapy and the importation of fresh cell therapy products intended for injections.…”

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confidence: 99%

Xenotransplantation: Where do we stand in 2016?

et al. 2017

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“…Notably, these cells were not even of human origin. It is truly astounding how 'fresh cell therapy' may be actually flourishing even today, a er the repeated reports of deaths following Niehans-type of rejuvena on treatments with animal (usually, sheep) cells [1160][1161][1162]. Examples of other rather short-lived theories of ageing are the 'mul ple hormone deficiency' theory, the 'immune suppression theory' and the 'loss of cellular water' theory.…”

Section: Dna Repair and Ageingmentioning

confidence: 99%

DNA repair systems

Chakarov¹,

Petkova²,

Russev³

2014

Biodiscovery

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This paper provides detailed insight into the mechanisms of repair of different types of DNA damage and the direct molecular players (enzymes repairing the damage or tagging the damaged site for further processing; damage sensor molecules; other signalling and effector molecules). The gene c bases of diseases and condi ons associated with defec ve DNA repair are comprehensively reviewed, from the 'classic' severe diseases such as xeroderma pigmentosum and Cockayne syndrome to the much more subtle UV sensi vity syndromes. The review analyses the basic molecular mechanisms underlying the rela vely rare monogenic diseases of DNA repair and management of genome integrity as well as the common mul factorial diseases and condi ons with late onset that are associated with increased levels of oxida ve stress (metabolic syndrome, diabetes type 2, cardiovascular disease) and with accumula on of 'errors' in DNA (normal and pathological ageing phenotypes, various cancers). The role of cell cycle checkpoints in dividing cells and the mechanisms of decision-making for the fate of a damaged cell are discussed with regards to the cell homeostasis in normal and cancerous ssues. The role of major DNA damageassociated signalling and effector molecules (p53, ATM, poly-(ADP-ribose)-polymerase, DNA-dependent protein kinase, BRCA proteins, re noblastoma protein, and others) is discussed and illustrated with examples in the context of health and disease. DNA repair and programmed cell death are viewed together as a unified mechanism for limi ng the presence of damaged cells and cells with poten ally oncogenic transforma on in mul cellular organisms. Special a en on is paid to ageing as a natural phenomenon and an adap ve evolu onary mechanism, with a brief outline of 'successful ageing'. The differen al rates of repair of DNA in transcribed and nontranscribed regions of the genome and the specifici es of DNA repair profile in some types of cells (terminally differen ated cells, pluripotent stem cells, etc.) and in certain taxonomic groups (e.g. 'the rodent repairadox') are discussed with regards to replica ve ageing and the evolu onary processes on microand macroscale. The role of mutagenesis as a 'hit and miss' mechanism and the 'leakiness' of DNA repair for increasing gene c diversity in the course of individual life and on evolu onary scale and the phenomenology of ongoing molecular evolu on are extensively reviewed. Conflict of Interests:No poten al conflict of interest was disclosed by any of the authors. Types of DNA repair systemsIf you wish for peace, prepare for war.Publius Flavius Vege us Renatus, De Re Militari (circa 380 AD).DNA damage is a very broad term, encompassing many different types of lesions in DNA.Accordingly, DNA repair comprises many different types of pathways and mechanisms covering virtually every possible type of injury to the sequence or the structure of DNA.Accep ng Lewin's defini on of DNA damage "... any change that introduces a devia on from the usual double-helical structure" [1] , we may pre...

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Fresh cell therapy followed by fatal coma

Cited by 18 publications

References 14 publications

Complementary and alternative medicine for multiple sclerosis

Complementary and alternative medicine for multiple sclerosis

Xenotransplantation: Where do we stand in 2016?

DNA repair systems

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