FRET-based ratiometric fluorescent detection of arginine in mitochondrion with a hybrid nanoprobe

Li, Yueyue; Ban, Yanan; Wang, Ruihui; Wang, Zheng; Li, Zhanxian; Fang, Chen‐Jie; Yu, Mingming

doi:10.1016/j.cclet.2019.07.047

Cited by 64 publications

(7 citation statements)

References 59 publications

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“…In addition to single molecular modulation strategies, the combination of various fluorophores is useful for forming signal transfer processes (Figure 13a). [116,117] Upon combining two or more fluorophores together, the structure of a single molecule can be achieved conveniently. As the signal transfer potential behind the selected fluorophores was required, the modulation in this aspect should focus on developing a signal transmission pathway rather than a fluorophore.…”

Section: Combination Of Fluorophores To Generate Multiple Signal Transfer Processesmentioning

confidence: 99%

Rational Modulation Strategies to Improve Bioimaging Applications for Organic NIR‐II Fluorophores

Wang

She

Chen

et al. 2021

Advanced Optical Materials

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with optical simulation and empirical derivation is considered as "biologicalappropriate". [10,11] In addition, the autofluorescence intensity, effective attenuation coefficient, and scattering coefficient of biological components are significantly minimized in the NIR-II region (Figure 1). [12,13] Initially, Kevin Welsher et al. reported that the most prominent advantage of the reduced adverse factors is a deeper penetration depth beyond 1 µm by exploiting single-walled carbon nanotubes (SWNTs). [14] However, Smith et al. highlighted that the nonbiodegradable nature and needle-like structure of SWNTs can cause tissue damage and chronic toxicity. [12] Moreover, optical bioimaging in clinical applications employs small fluorescent molecules as imaging agents. [4] Consequently, current research progressively focuses on the relatively compact and minimally toxic nature of organic fluorophores that can be observed in NIR-II fluorescence imaging.Based on the development of organic NIR-II fluorophores, construction and modification are considered as two essential parts of interest. As diverse synthetic methods enable the combination of functional building blocks for facilitating NIR-II fluorescence, the modulation is vital for developing NIR-II fluorescence imaging. Although the biosafety of organic NIR-II fluorophores is a major concern, its advantages can be completely exploited based on its biocompatibility. [4,17,18] Therefore, the bioapplication of organic NIR-II fluorophores can be simultaneously enriched. An additional issue pertains to the unsatisfactory fluorescence quantum yield (QY) of organic NIR-II fluorophores. The simultaneous regulation of the ground and excited states promotes the easy-to-be-quenched property of organic NIR-II fluorophores, which adversely affects the fluorescence QY. [19,20] Moreover, the activatable properties exhibited by organic NIR-II fluorophores are related to modulation to induce a smarter signal output model rather than the "always ON" type.This study reviews the construction of organic NIR-II fluorophores in various molecular types (e.g., donor-acceptor (D-A) type, organic small molecules with π-conjugation systems, and organic polymers with π-conjugation systems). In addition, the modulation strategies for improving biosafety, fluorescence QY, biotargeting ability, and signal activatable features are summarized as well. Furthermore, this study highlights the current limitations that should be addressed in depth, including the future direction of the modulation strategy for the development of organic NIR-II fluorophores.The second near-infrared (NIR-II) window is highly effective in fluorescent bioimaging to obtain a deep view of living systems. Among numerous NIR-II fluorescent agents, organic fluorophores have been considered as ideal candidates in this field. Thus, modulation strategies should be considered to improve the performance and functionality of such agents. This review provides an overview of the development and construction of organic NIR-II fluorophores. More i...

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Section: Combination Of Fluorophores To Generate Multiple Signal Transfer Processesmentioning

confidence: 99%

Rational Modulation Strategies to Improve Bioimaging Applications for Organic NIR‐II Fluorophores

Wang

She

Chen

et al. 2021

Advanced Optical Materials

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“…) showed no obvious quenching effect 44,45 (black bars). Therefore, it could be considered that other metal ions had little effect.…”

Section: Detection Of Cr(vi)mentioning

confidence: 99%

Fluorescent “on–off–on” sensor based on N,S co-doped carbon dots from seaweed (Sargassum carpophyllum) for specific detection of Cr(vi) and ascorbic acid

Tian

et al. 2021

RSC Adv.

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“…Optical probes have been a powerful tool for monitoring and imaging anions, cations, enzymes, and biomolecules in vitro / vivo because of their easy operation, high sensitivity, good selectivity, and noninvasive detection ( Chen et al, 2018a ; Hou et al, 2020 ; Li et al, 2020 ; Park et al, 2020 ; Yang et al, 2020 ; Cui et al, 2021 ; Du et al, 2021 ). At present, a huge amount of fluorescent probes have been developed for the investigation of Cys, Hcy, and GSH in living cells based on cyclization with aldehyde, Michael addition, cleavage of sulfonamide, disulfide, selenium–nitrogen, and sulfonate ester ( Chen et al, 2018b ; Chen et al, 2020 ; Yue et al, 2020 ; Chen et al, 2021a ; Li et al, 2021a ; Zhang et al, 2021a ; Zheng et al, 2021 ; Chen et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Discrimination of Cys/Hcy and GSH With Simple Fluorescent Probe Under a Single-Wavelength Excitation and its Application in Living Cells, Tumor Tissues, and Zebrafish

Yan

Liu

et al. 2022

Front. Chem.

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Owing to the important physiological sits of biothiols (Cys, Hcy, and GSH), developing accurate detection methods capable of qualitative and quantitative analysis of biothiols in living systems is needed for understanding the biological profile of biothiols. In this work, we have designed and synthesized a 4′-hydroxy-[1,1′-biphenyl]-4-carbonitrile modified with NBD group-based fluorescent probe, BPN-NBD, for sensitive detection of Cys/Hcy and GSH by dual emission signals via a single-wavelength excitation. BPN-NBD exhibited an obvious blue fluorescence (λmaxem = 475 nm) upon the treatment with GSH and reacted with Cys/Hcy to give a mixed blue-green fluorescence (λmaxem = 475 and 545 nm). Meanwhile, BPN-NDB performed sufficient selectivity, rapid detection (150 s), high sensitivity (0.011 µM for Cys, 0.015 µM for Hcy, and 0.003 µM for GSH) and could work via a single-wavelength excitation to analytes and had the ability to image Cys/Hcy from GSH in living MCF-7 cells, tumor tissues, and zebrafish by exhibiting different fluorescence signals. Overall, this work provided a powerful tool for thiols visualization in biological and medical applications.

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FRET-based ratiometric fluorescent detection of arginine in mitochondrion with a hybrid nanoprobe

Cited by 64 publications

References 59 publications

Rational Modulation Strategies to Improve Bioimaging Applications for Organic NIR‐II Fluorophores

Rational Modulation Strategies to Improve Bioimaging Applications for Organic NIR‐II Fluorophores

Fluorescent “on–off–on” sensor based on N,S co-doped carbon dots from seaweed (Sargassum carpophyllum) for specific detection of Cr(vi) and ascorbic acid

Simultaneous Discrimination of Cys/Hcy and GSH With Simple Fluorescent Probe Under a Single-Wavelength Excitation and its Application in Living Cells, Tumor Tissues, and Zebrafish

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