FRI0714 Lupus nephritis and prognosis. effect of membranous and other components of the histology

Abstract

BackgroundIn 1983 Austin et al. informed a series of prognostic factors (including histology) associated with the development of renal failure in patients with lupus nephritis (LN). Differences in actual therapies may have different hazard ratios of renal failure than the described by Austin et al.1ObjectivesTo evaluate histological factors associated with a decline in kidney function (DKF) in patients with SLE.MethodsWe evaluated all the patients in whom a kidney biopsy was performed. DKF was defined as a glomerular filtration rate (GFR) of less than 60 ml/min/m2 in two determinations in the follow-up. Histology was graded according to Austin et al.1 (activity and chronicity) by a renal pathology specialist. Factors associated with the development of DKF were evaluated through Kaplan-Meier curves and Cox regression analysis (bivariate and multivariate).ResultsAt this moment, we have followed 170 patients with LN and kidney biopsy, 130 (76.5%) women, mean age at kidney biopsy was 29.7±13.2 years; classes of LN were: 71 patients (41.8%) class IV, 30 (17.6%) class V, 22 (12.9%) class III/V, 19 (11.2%) class IV/V, 16 (9.4%) class III, and other classes 12 patients; 135 patients (79.5%) have a minimum follow-up of 12 months. There were statistically significant differences in four groups of LN: pure proliferative (classes III or IV), the combination with membranous (III/IV±V), pure membranous (V) or other classes (Figure1).In the bivariate analysis, factors statistically significant associated with the development of DKF were: glomerular sclerosis, fibrous crescents, interstitial cell infiltration and tubular atrophy; having membranous component resulted as a “protector” factor for the development of DKF. The Cox regression model included all the factors with a p-value less than 0.25 in the bivariate analysis; independent factors associated with increased HR of DKF were glomerular sclerosis and fibrous crescents; however, hyaline thrombi and presence of membranous nephritis were associated with a decreased HR of DKF. (Table 1).Table 1.Factors associated with a DKFHistological featureBivariateBivariateMultivariateMultivariate HR (CI)p-valueHR (CI)p-value Glomerular abnormalities Cellular proliferation1.01 (0.83–1.22)0.920NANA Karyorrhexis0.94 (0.76–1.17)0.566NANA Celular crescents1.09 (0.96–1.22)0.1790.95 (0.82–1.10)0.501484 Hyaline thrombi0.85 (0.64–1.12)0.2480.65 (0.47–0.90)0.008837 Leukocyte infiltration1.23 (0.97–1.57)0.08481.03 (0.77–1.40)0.815447 Glomerular sclerosis1.79 (1.41–2.26)<0.0011.67 (1.23–2.25)0.000838 Fibrous crescents1.71 (1.27–2.29)<0.0011.55 (1.11–2.16)0.009917 Membranous0.50 (0.30–0.85)0.01050.48 (0.27–0.88)0.017001Tubulointerstitial abnormalities Interstitial cell infiltration1.31 (1.13–1.56)<0.0011.18 (0.95–1.47)0.126099 Interstitial fibrosis0.80 (0.92–1.70)0.1620.74 (0.47–1.16)0.194012 Tubular atrophy1.33 (1.02–1.74)0.0351.10 (0.47–1.17)0.613154ConclusionsWe describe factors associated with a DKF. We found that the proliferative LN in combination with membranous have a better prognosis than pu...

FRI0714 Lupus nephritis and prognosis. effect of membranous and other components of the histology

“…Also, the increased likelihood of suffering from hypertension, venous peripheral vascular disease and gastroesophageal reflux should determine chronic medications for the treatment of osteoarthritis. Thrombosis and Haemophilia,Guy's and St Thomas' Hospital,London,United Kingdom;3 S. Giovanni BoscoHospital,Torino,Italy;4 Guy's and St Thomas' NHS Foundation Trust,London,United Kingdom Background: Young adults with acute myocardial infarction are a critical group to examine for the purpose of risk factors stratification and modification [1]. In the setting of underlying systemic autoimmune diseases, premature cardiovascular disease deserves even more attention in these conditions, such as antiphospholipid syndrome (APS), the most common acquired thrombophilia.…”

“…This is a growing concern, given the population trajectories, and requires urgent attention. References: [1] (LN). Differences in actual therapies may have different hazard ratios of renal failure than the described by Austin et al 1 Objectives: To evaluate histological factors associated with a decline in kidney function (DKF) in patients with SLE.…”

“…DKF was defined as a glomerular filtration rate (GFR) of less than 60 ml/min/m 2 in two determinations in the follow-up. Histology was graded according to Austin et al 1 (activity and chronicity) by a renal pathology specialist. Factors associated with the development of DKF were evaluated through Kaplan-Meier curves and Cox regression analysis (bivariate and multivariate).…”