Friction measurements on phase-separated thin films with a modified atomic force microscope

Overney, René M.; Meyer, Ernst; Frommer, Jane; Brodbeck, D.; Lüthi, R.; Howald, L.; Giintherodt, H.-J.; Fujihira, Masamichi; Takano, Hajime; Gotoh, Y.

doi:10.1038/359133a0

Cited by 527 publications

(292 citation statements)

References 29 publications

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“…9 Fluorinated soft NPs have been, indeed, proposed as drug delivery systems for doxorubicin. 10,11 An additional feature of fluorinated materials, including AuNPs, is that they may be easily engineered into contrast agents for 19 F magnetic resonance imaging, 12,13 and by combining this application with drug delivery, novel theranostic platforms may become available. 11 As far as monolayer protected AuNPs are concerned, the immiscibility of F-and H-thiolate ligands, arising from the lipophobicity of fluorocompounds, favors their self-sorting, with formation of domains, on the NPs surface.…”

Section: ■ Introductionmentioning

confidence: 99%

“…The same behavior was also observed by AFM in a supported lipid bilayer of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine and of a semifluorinated analogue 18 or in mixtures of arachidic and partially fluorinated carboxylic acids. 19 On the other hand, studies on mixed hydrogenated/fluorinated self-assembled monolayers (SAMs) on flat surfaces are suggestive of less facile phase segregation. In particular, the adsorption on Au(111) of mixed disulfides featuring a hydrogenated chain and a fluorinated chain of different lengthsin a single disulfide molecule results in the formation of SAMs with no evidence of phase segregation.…”

Section: ■ Introductionmentioning

confidence: 99%

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Fluorinated and Charged Hydrogenated Alkanethiolates Grafted on Gold: Expanding the Diversity of Mixed-Monolayer Nanoparticles for Biological Applications

et al. 2016

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Low intrinsic toxicity, high solubility, and stability are important and necessary features of gold nanoparticles to be used in the biomedical field. In this context, charged nanoparticles proved to be very versatile, and among them charged mixed-monolayer gold nanoparticles, displaying monolayers with well-defined morphologies, represent a paradigm. By using mixtures of hydrogenated and fluorinated thiols, the formation of monolayer domains may be brought to an extreme because of the immiscibility of fluorinated and hydrogenated chains. Following this rationale, mixed monolayer gold nanoparticles featuring ammonium, sulfonate, or carboxylic groups on their surface were prepared by using amphiphilic hydrogenated thiols and 1H,1H,2H,2H-perfluoro-alkanethiols. The toxicity of these systems was assessed in HeLa cells and was found to be, in general, low even for the cationic nanoparticles which usually show a high cytotoxicity and is comparable to that of homoligand gold nanoparticles displaying amphiphiliccharge neutralhydrogenated or fluorinated thiolates in their monolayer. These properties make the mixed ligand monolayer gold nanoparticles an interesting new candidate for medical application.

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Section: ■ Introductionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

Fluorinated and Charged Hydrogenated Alkanethiolates Grafted on Gold: Expanding the Diversity of Mixed-Monolayer Nanoparticles for Biological Applications

et al. 2016

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“…5). It is known that friction and topography influence each other during the contact mode SFM imaging [27,28]. Frictional SFM imaging of a stamped film of alkanethiols on gold has also demonstrated that areas differing in terms of surface chemistries can be resolved through lateral force imaging [16].…”

Section: Discussionmentioning

confidence: 99%

Chemical pattern on silica surface prepared by UV irradiation of 3-mercaptopropyltriethoxy silane layer: surface characterization and fibrinogen adsorption

Liu¹,

Hlady²

1996

Colloids and Surfaces B: Biointerfaces

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A flat silica surface modified with 3-mercaptopropyltriethoxy silane (MTS) was patterned using UV irradiation and a custom-designed mask. The irradiated surface was characterized by X-ray photoelectron spectroscopy (XPS), scanning force microscopy (SFM) and water contact angle measurements. The XPS S2p spectra indicated that the UV treatment resulted in the oxidation of MTS sulfur. The optimal UV irradiation dose for patterning, estimated from the XPS S2p binding energy shifts and water contact angles of irradiated surfaces, was 4.8 J cm −2 at 270 nm. The surface patterns were visualized by total internal reflection fluorescence microscopy, while exposing the pattern to a solution of acridine orange, by water vapor condensation, and by SFM lateral force imaging in dilute electrolyte solution. The adhesion SFM measurements revealed the adhesion force only on the areas which were not UV-irradiated. The adsorption of fluoresceinlabeled fibrinogen (FITC-Fgn) from dilute buffer solution also produced visual information on the pattern. The kinetics of FITC-Fgn adsorption onto the oxidized and unoxidized MTS-silica surfaces from dilute protein solution proceeded with identical initial adsorption rates. The steadystate FITC-Fgn adsorption was twice as large on the unoxidized MTS-silica than on the oxidized MTS-silica surface.

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“…This would induce a higher friction force on the PET surface than on the PP surface. Indeed, it has been previously shown that the friction force is higher on fluorinated Langmuir-Blodgett films than on their hydrogen-containing counterpart because the shear resistance of the fluorinated films is higher [17]. These results shows that lat-eral force microscopy could be used to reveal chemical heterogeneities at the surface of polymer blends.…”

mentioning

confidence: 60%

SEM, ToF-SIMS and LFM morphological study of an heterogeneous polymeric surface

Nysten

Verfaillie

Ferain

et al. 1994

Microsc. Microanal. Microstruct.

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The surface morphology of films prepared with 20% of PP and 80% of PET has been studied by means of various methods: scanning electron microscopy (SEM), time of flight secondary ion mass spectrometry (ToF-SIMS) and lateral force microscopy (LFM). The three methods revealed an heterogeneous surface with a continuous phase including nodules whose size ranges from approximately 1 03BCm to more than 100 03BCm. ToF-SIMS analyses identified the chemical nature of this heterogeneity: the continuous phase is PET and the nodules are PP. SEM and LFM were also found to be able to image the surface nodules. This study proved the complementarity of the three methods for the characterisation of the surface morphology of polymer blends.

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Friction measurements on phase-separated thin films with a modified atomic force microscope

Cited by 527 publications

References 29 publications

Fluorinated and Charged Hydrogenated Alkanethiolates Grafted on Gold: Expanding the Diversity of Mixed-Monolayer Nanoparticles for Biological Applications

Fluorinated and Charged Hydrogenated Alkanethiolates Grafted on Gold: Expanding the Diversity of Mixed-Monolayer Nanoparticles for Biological Applications

Chemical pattern on silica surface prepared by UV irradiation of 3-mercaptopropyltriethoxy silane layer: surface characterization and fibrinogen adsorption

SEM, ToF-SIMS and LFM morphological study of an heterogeneous polymeric surface

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