Friction properties of a new silk fibroin scaffold for meniscal replacement

Warnecke, Daniela; Schild, Natalie; Klose, Svenja; Joos, Helga; Brenner, Rolf E.; Kessler, Oliver; Skaer, Nick; Walker, Robert; Freutel, Maren; Ignatius, Anita; Dürselen, Lutz

doi:10.1016/j.triboint.2017.01.038

Cited by 23 publications

(28 citation statements)

References 37 publications

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“…We recently reported friction coefficients of around 0.056 of a silk fibroin scaffold for partial meniscal replacement, which is in the range of the requirements for meniscal replacements postulated by Rongen et al . 17,18 .…”

Section: Introductionmentioning

confidence: 99%

Articular cartilage and meniscus reveal higher friction in swing phase than in stance phase under dynamic gait conditions

Warnecke¹,

Meßemer²,

Roy³

et al. 2019

Sci Rep

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Most previous studies investigated the remarkably low and complex friction properties of meniscus and cartilage under constant loading and motion conditions. However, both load and relative velocity within the knee joint vary considerably during physiological activities. Hence, the question arises how friction of both tissues is affected by physiological testing conditions occurring during gait. As friction properties are of major importance for meniscal replacement devices, the influence of these simulated physiological testing conditions was additionally tested for a potential meniscal implant biomaterial. Using a dynamic friction testing device, three different friction tests were conducted to investigate the influence of either just varying the motion conditions or the normal load and also to replicate the physiological gait conditions. It could be shown for the first time that the friction coefficient during swing phase was statistically higher than during stance phase when varying both loading and motion conditions according to the physiological gait pattern. Further, the friction properties of the exemplary biomaterial were also higher, when tested under dynamic gait parameters compared to static conditions, which may suggest that static conditions can underestimate the friction coefficient rather than reflecting the in vivo performance.

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Section: Introductionmentioning

confidence: 99%

Articular cartilage and meniscus reveal higher friction in swing phase than in stance phase under dynamic gait conditions

Warnecke¹,

Meßemer²,

Roy³

et al. 2019

Sci Rep

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“…A silk fibroin scaffold (FibroFix™; Orthox Ltd., Abingdon, UK) was previously developed and investigated in several in vitro and in vivo studies . The in vivo performance of the first generation of silk fibroin scaffolds was evaluated in a partial meniscal defect in the ovine model .…”

Section: Introductionmentioning

confidence: 99%

Meniscal Replacement With a Silk Fibroin Scaffold Reduces Contact Stresses in the Human Knee

Stein

Höse

Warnecke

et al. 2019

Journal Orthopaedic Research

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The aim of the current study was to verify if a previously developed silk fibroin scaffold for meniscal replacement is able to restore the physiological distribution of contact pressure (CP) over the articulating surfaces in the human knee joint, thereby reducing peak loads occurring after partial meniscectomy. The pressure distribution on the medial tibial articular surface of seven human cadaveric knee joints was analysed under continuous flexion-extension movements and under physiological loads up to 2,500 N at different flexion angles. Contact area (CA), maximum tibiofemoral CP, maximum pressure under the meniscus and the pressure distribution were analysed for the intact meniscus, after partial meniscectomy as well as after partial medial meniscal replacement using the silk fibroin scaffold. Implantation of the silk fibroin scaffold considerably improved tibiofemoral contact mechanics after partial medial meniscectomy. While the reduced CA after meniscectomy was not fully restored by the silk fibroin scaffold, clinically relevant peak pressures on the articular cartilage surface occurring after partial meniscectomy were significantly reduced. Nevertheless, at high flexion angles static testing demonstrated that normal pressure distribution comparable to the intact meniscus could not be fully achieved. The current study demonstrates that the silk fibroin implant possesses attributes that significantly improve tibiofemoral CPs within the knee joint following partial meniscectomy. However, the failure to fully recapitulate the CAs and pressures observed in the intact meniscus, particularly at high flexion angles, indicates that the implant's biomechanical properties may require further improvement to completely restore tibiofemoral contact mechanics.

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“…As estratégias para correção das lesões são complexas. O procedimento ortopédicos mais empregado é a meniscectomia que consiste na remoção tecidual da área lesionada (5,14,15,19,21,22,24,(26)(27)(28)(29). Entretanto a diminuição do tecido conduz à perda das funções meniscais e consequentemente ao desenvolvimento da degeneração da cartilagem, perturbando a qualidade de vida dos pacientes (14,21,30).…”

Section: Capítulo 10unclassified

“…Pois, deve-se evitar a rejeição do dispositivo ou proliferação de organismos nocivos ao corpo humano. Por isto, alguns estudos escolhem materiais naturais (38,42) como o colágeno(48) e a seda (18,22). Um dos métodos para a produção de scaffold de matriz extracelular é o processo de descelularização de meniscos (1,19,25,27,29,44,58).…”

Section: Metodologiaunclassified