Comprehensive Organic Synthesis 1991
DOI: 10.1016/b978-0-08-052349-1.00065-2
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Friedel–Crafts Alkylations

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Cited by 265 publications
(153 citation statements)
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“…[1] Recently, with the development of organocatalysis, [2] it is now also possible to perform enantioselective Friedel-Crafts alkylation [3] in the presence of a chiral amine, in particular, and protic acid as co-catalyst. However, many of these procedures frequently require large quantities of Lewis or protic acid catalysts that are destroyed during work-up and cause corrosion problems.…”
Section: Introductionmentioning
confidence: 99%
“…[1] Recently, with the development of organocatalysis, [2] it is now also possible to perform enantioselective Friedel-Crafts alkylation [3] in the presence of a chiral amine, in particular, and protic acid as co-catalyst. However, many of these procedures frequently require large quantities of Lewis or protic acid catalysts that are destroyed during work-up and cause corrosion problems.…”
Section: Introductionmentioning
confidence: 99%
“…) have classically been conducted with stoichiometric quantities of the catalyst. [2] In recent times there have been extensive efforts to find catalytic reaction conditions for the Friedel-Crafts alkylation with alcohols and their derivatives. Highly effective Lewis acids have been found which catalyze cleanly the reaction of various arenes with alcohols [3] and acetates.…”
Section: Introductionmentioning
confidence: 99%
“…Friedel-Crafts 反应是形成碳碳键最有效的方法之 一 [1] , 其中, 吲哚类化合物是重要的 Friedel-Crafts 反应 单元 [2] , 并存在于许多生物分子、医药化学和有机合成 中间体中. 另外, 吲哚的 Friedel-Crafts 烷基化产物--双吲哚甲烷, 具有广泛的生物活性, 如抗菌和抗肿瘤等 特性 [3,4] .…”
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