Friedel–Crafts chemistry 56*. Unprecedented construction of functionalized polycyclic quinolines via Friedel–Crafts cycliacylation and Beckmann rearrangement

Design and diversity-oriented synthesis of benzo- and pyrido-annulated medium-sized N,S-heterocycles via thio-Michael and Friedel-Crafts approaches

“…With these importances in mind, we sought to design a facile protocol for the attempt of accessing medium-sized N&Sheterocycles focusing on achieving molecular diversity and efficiency. In continuation of our research interests in Friedel-Crafts reactions [19][20][21][22] regarding the development of concise methods for the construction carbo-and heterocycles, [23][24][25][26][27] herein, we wish to report the concise synthesis of condensed medium-sized N&Sheterocyclic scaffolds (e.g. tetracyclic benzo-and pyrido-fused 1,4-thiazoninones, 1,4-thiazecinones and 1,4-thiazacycloundecanones) through the Friedel-Crafts ring closures of ester precursors.…”