Friedreich Ataxia: Treatment with Genetic Approach

Nelwan, Martin

doi:10.9734/jabb/2017/36113

Cited by 14 publications

(15 citation statements)

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“…This technique includes gene delivery vectors such as rAAV [55] and the CRISPR/Cas9 system [55], and iPSCs technique. For disease modeling, drug screening, and stem cell therapy; the iPSCs technique is helpful [56][57][58]. In addition, the iPSCs technique in combination with a CRISPR/Cas9 system or NHJE-based technique for treating rabies may also be developed.…”

Section: Discussionmentioning

confidence: 99%

“…The author did not find any reference relating to iPSCs and CRISPR/Cas9 system for treating rabies. However, Nelwan indicated that genedelivery tools, gene-editing tools, NHEJ-based technique, for instance, (M Nelwan, Nelwan Institution for Human Resource Development, INDONESIA, Unpublished results), and iPSCs technique are used to treat monogenic disorders [55][56][57].…”

Section: Treatment With Gene Therapymentioning

confidence: 99%

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Eradicate Rabies with Mass Parental Vaccination, Human Post-Exposure Prophylaxis, and Gene Therapy: A Systematic Review

Nelwan¹

2018

Preprint

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Aims: To review canine rabies, mass parental vaccination, human post-exposure prophylaxis, gene therapy and costs for fighting rabies. Place and Duration of Study: Department of Animal Science – Other, Nelwan Institution for Human Resource Development, Indonesia, between December 2017 and March 2018. Methodology: The author searched the Pubmed Database at NCBI for articles on rabies disease published between 2007 and 2018. All articles were open access and in English. For rabies virus examination, Seller’s test was used. In this article, references written by the author and other relevant publications were included. The author reviewed a rabies dog case kept at Nelwan Institution for Human Resource Development. Results: The dog showed clinical signs such as inappetance, urinary frequency and soaking in a small, juicy drain. Currently, to treat rabies, no drugs are available. For rabies prevention, vaccination is the best way. To eradicate rabies, mass vaccination in dogs, post-exposure prophylaxis, and gene therapy should be used.  Fort rabies disease eradication, minimum of 70% of the dog population should receive the vaccination. In addition, humans with category II exposure should receive a rabies vaccine and rabies immunoglobulin. Conclusion: To eradicate rabies, vaccinations are required. In addition, gene therapy can eliminate rabies from the infected neurons by using rAAV-N796. CRISPR/Cas9 system in combination with the MMEJ-based method. Furthermore, mass parental vaccination, post-exposure prophylaxis, and gene therapy can reduce costs in controlling rabies disease.

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Section: Discussionmentioning

confidence: 99%

Section: Treatment With Gene Therapymentioning

confidence: 99%

Eradicate Rabies with Mass Parental Vaccination, Human Post-Exposure Prophylaxis, and Gene Therapy: A Systematic Review

Nelwan¹

2018

Preprint

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“…Chen et al localized the MAOA and MAOB genes within a region of about 240 kb [10]. The MAOA and MAOB derived from duplication of the MAO gene [3][4][5][6][7][8][9][10]. The MAOA gene encodes mitochondrial enzymes.…”

Section: Genes In Antisocial Behaviormentioning

confidence: 99%

“…To diminish antisocial behavior, for instance, advanced therapy such as CRISPR/Cas9 system in combination with iPSCs technology can be used. This combination may be helpful to treat diseases inherited through X-linked pattern [6][7].…”

Section: Mutations In the Maoa Gene For The Antisocial Behaviormentioning

confidence: 99%

“…For this purpose, gene-editing techniques can be used. The gene-editing technique in combination with induced pluripotent stem cells (iPSCs) or homologous recombination (HR) is useful to fix erroneous segment in genes such as MAOA gene and F8 gene [6,7]. Clustered regularly interspaced short palindromic repeats (CRISPR/Cas9) system is one of the genes-editing techniques.…”

Section: Introductionmentioning

confidence: 99%

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