Friend or foe of innate lymphoid cells in inflammation‐associated cardiovascular disease

Gong, Xiangmei; Xia, Lin; Su, Zhaoliang

doi:10.1111/imm.13271

Cited by 3 publications

(3 citation statements)

References 133 publications

(146 reference statements)

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“…Different subtypes of cardiomyocytes can be distinguished: sinoatrial nodal cells, atrioventricular nodal cells, atrial cells, ventricular cells, and Purkinje cells [ 49 ].Those cells act in concert with a vascular system and multiple non-myocyte cells. The non-myocyte cells in the myocardium, which thus represent 65 to 75% of the cells, comprise the following: Endothelial cells , which border the myocardium capillaries [ 48 ] and are essential for cardiomyocyte survival and reorganization [ 50 ]; Vascular smooth muscle cells and pericytes , which sustain the vascular network and control the vascular tone [ 51 ]; Fibroblasts , which play a prominent role in the constitution of the supporting extracellular matrix and contribute to cardiomyocyte electrical coupling, conduction system insulation, vascular maintenance, and stress-sensing [ 52 , 53 ]; Neurons , which convey autonomic control of cardiac function through a brain–heart axis [ 54 ]; Immune cells , such as myeloid or lymphoid cells [ 55 , 56 ]; and Other rarer cells that can have key roles in the regulation of specific functions such as regeneration or fibrotic cardiac remodeling [ 57 ]. …”

Section: Cardiac Organoids To Reproduce the Features Of Human Cardiac Tissuementioning

confidence: 99%

Cardiac Organoids to Model and Heal Heart Failure and Cardiomyopathies

et al. 2021

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Cardiac tissue engineering aims at creating contractile structures that can optimally reproduce the features of human cardiac tissue. These constructs are becoming valuable tools to model some of the cardiac functions, to set preclinical platforms for drug testing, or to alternatively be used as therapies for cardiac repair approaches. Most of the recent developments in cardiac tissue engineering have been made possible by important advances regarding the efficient generation of cardiac cells from pluripotent stem cells and the use of novel biomaterials and microfabrication methods. Different combinations of cells, biomaterials, scaffolds, and geometries are however possible, which results in different types of structures with gradual complexities and abilities to mimic the native cardiac tissue. Here, we intend to cover key aspects of tissue engineering applied to cardiology and the consequent development of cardiac organoids. This review presents various facets of the construction of human cardiac 3D constructs, from the choice of the components to their patterning, the final geometry of generated tissues, and the subsequent readouts and applications to model and treat cardiac diseases.

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Section: Cardiac Organoids To Reproduce the Features Of Human Cardiac Tissuementioning

confidence: 99%

Cardiac Organoids to Model and Heal Heart Failure and Cardiomyopathies

et al. 2021

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“…Innate lymphoid cells (ILCs) are a family of immune cells recently shown to be implicated in inflammation, metabolism and tissue remodeling (5), and cardiovascular diseases such as AS (6)(7)(8), pericarditis (9), cardiac fibrosis (10)and MI (11). Gong et al summarized the roles of helper ILCs in inflammation-associated cardiovascular disease (12). However, the specific roles of ILCs in MI are still unclear.…”

Section: Introductionmentioning

confidence: 99%

“…Gong et al. summarized the roles of helper ILCs in inflammation-associated cardiovascular disease ( 12 ). However, the specific roles of ILCs in MI are still unclear.…”

Section: Introductionmentioning

confidence: 99%

Innate Lymphoid Cells and Myocardial Infarction

et al. 2021

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Myocardial infarction results from obstruction of a coronary artery that causes insufficient blood supply to the myocardium and leads to ischemic necrosis. It is one of the most common diseases threatening human health and is characterized by high morbidity and mortality. Atherosclerosis is the pathological basis of myocardial infarction, and its pathogenesis has not been fully elucidated. Innate lymphoid cells (ILCs) are an important part of the human immune system and participate in many processes, including inflammation, metabolism and tissue remodeling, and play an important role in atherosclerosis. However, their specific roles in myocardial infarction are unclear. This review describes the current understanding of the relationship between innate lymphoid cells and myocardial infarction during the acute phase of myocardial infarction, myocardial ischemia-reperfusion injury, and heart repair and regeneration following myocardial infarction. We suggest that this review may provide new potential intervention targets and ideas for treatment and prevention of myocardial infarction.

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Transcriptional profiles associated with coronary artery disease in type 2 diabetes mellitus

Nevado,

Cutiongco-de la Paz,

Paz-Pacheco

et al. 2024

Front. Endocrinol.

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BackgroundCoronary artery disease (CAD) is a common complication of Type 2 diabetes mellitus (T2DM). Understanding the pathogenesis of this complication is essential in both diagnosis and management. Thus, this study aimed to characterize the presence of CAD in T2DM using molecular markers and pathway analyses.MethodsThe study is a sex- and age-frequency matched case-control design comparing 23 unrelated adult Filipinos with T2DM-CAD to 23 controls (DM with CAD). Healthy controls served as a reference. Total RNA from peripheral blood mononuclear cells (PBMCs) underwent whole transcriptomic profiling using the Illumina HumanHT-12 v4.0 expression beadchip. Differential gene expression with gene ontogeny analyses was performed, with supporting correlational analyses using weighted correlation network analysis (WGCNA).ResultsThe study observed that 458 genes were differentially expressed between T2DM with and without CAD (FDR<0.05). The 5 top genes the transcription factor 3 (TCF3), allograft inflammatory factor 1 (AIF1), nuclear factor, interleukin 3 regulated (NFIL3), paired immunoglobulin-like type 2 receptor alpha (PILRA), and cytoskeleton-associated protein 4 (CKAP4) with AUCs >89%. Pathway analyses show differences in innate immunity activity, which centers on the myelocytic (neutrophilic/monocytic) theme. SNP-module analyses point to a possible causal dysfunction in innate immunity that triggers the CAD injury in T2DM.ConclusionThe study findings indicate the involvement of innate immunity in the development of T2DM-CAD, and potential immunity markers can reflect the occurrence of this injury. Further studies can verify the mechanistic hypothesis and use of the markers.

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Friend or foe of innate lymphoid cells in inflammation‐associated cardiovascular disease

Cited by 3 publications

References 133 publications

Cardiac Organoids to Model and Heal Heart Failure and Cardiomyopathies

Cardiac Organoids to Model and Heal Heart Failure and Cardiomyopathies

Innate Lymphoid Cells and Myocardial Infarction

Transcriptional profiles associated with coronary artery disease in type 2 diabetes mellitus

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