Innate Lymphoid Cells and Myocardial Infarction

Abstract

Myocardial infarction results from obstruction of a coronary artery that causes insufficient blood supply to the myocardium and leads to ischemic necrosis. It is one of the most common diseases threatening human health and is characterized by high morbidity and mortality. Atherosclerosis is the pathological basis of myocardial infarction, and its pathogenesis has not been fully elucidated. Innate lymphoid cells (ILCs) are an important part of the human immune system and participate in many processes, including inflammation, metabolism and tissue remodeling, and play an important role in atherosclerosis. However, their specific roles in myocardial infarction are unclear. This review describes the current understanding of the relationship between innate lymphoid cells and myocardial infarction during the acute phase of myocardial infarction, myocardial ischemia-reperfusion injury, and heart repair and regeneration following myocardial infarction. We suggest that this review may provide new potential intervention targets and ideas for treatment and prevention of myocardial infarction.

Prognosis of extracorporeal membrane oxygenation (ECMO) treatment on cardiac shock after acute myocardial infarction: A bioinformatic analysis

“…Cardiac remodeling after MI may lead to serious consequences such as heart failure and cardiac rupture. In ammation and immune responses are the main responses after myocardial injury and play an important role in cardiac remodeling [20]. As important innate immune cells, macrophages play an important role in the in ammatory response and cardiac remodeling after MI of phagocytosis of necrotic cells and debris [21].…”

Revisiting Cardiac Biology in the Era of Single Cell and Spatial Omics

“…140 Recent studies have highlighted the importance of previously overlooked populations, such as cardiac B and plasma cells 141 which are believed to contribute to the pathogenesis of certain autoimmune and inflammatory heart diseases. Although the role of innate leukocyte cells and other innate immune cells remains to be elucidated, they have gained attention for their role in the immune response to MI 142 The interactions between immune and cardiac cells (such as cardiomyocytes, fibroblasts, and endothelial cells) are complex and critical for the heart's response to stress and injury. For example, activated macrophages can secrete cytokines and growth factors that influence cardiomyocyte function and fibroblast activation, leading to tissue remodeling or fibrosis.…”

Post-myocardial infarction fibrosis: Pathophysiology, examination, and intervention

“…At the meantime, macrophages also can be classified as classically activated (M1) or alternatively activated (M2) based on stimulatory environment. M1 macrophages degrade ECM and clear cell debris, and M2 macrophages promote angiogenesis and collagen deposition ( Yang et al, 2021b ). Further, M2b macrophages promote lymphangiogenesis to reduce myocardial fibrosis and cardiac dysfunction ( Wang et al, 2022b ).…”