Friend or foe, the role of EGR-1 in cancer

Li, Tongtong; Liu, Man-Ru; Pei, Dong‐Sheng

doi:10.1007/s12032-019-1333-6

Cited by 53 publications

(41 citation statements)

References 73 publications

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“…EGR1 , also named zinc finger protein 225 ( Zif268 ), Drosophila Kr finger probe 24 ( Krox24 ), tetradecanoyl phorbol acetate-induced sequence 8 (TIS8), and nerve growth factor-induced clone A ( NGFI-A ), is an immediate-early response gene that encodes a transcription factor containing three Cys2-His2-type zinc finger DNA-binding domains [ 53 ]. It regulates various cellular pathophysiological responses, including inflammation, synaptic plasticity, female reproduction, cell proliferation, apoptosis, and carcinogenesis [ 54 , 55 , 56 , 57 , 58 , 59 ].…”

Section: Discussionmentioning

confidence: 99%

Chrysin Inhibits TNFα-Induced TSLP Expression through Downregulation of EGR1 Expression in Keratinocytes

Yeo

Lee

Ahn

et al. 2021

IJMS

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Thymic stromal lymphopoietin (TSLP) is an epithelial cell-derived cytokine that acts as a critical mediator in the pathogenesis of atopic dermatitis (AD). Various therapeutic agents that prevent TSLP function can efficiently relieve the clinical symptoms of AD. However, the downregulation of TSLP expression by therapeutic agents remains poorly understood. In this study, we investigated the mode of action of chrysin in TSLP suppression in an AD-like inflammatory environment. We observed that the transcription factor early growth response (EGR1) contributed to the tumor necrosis factor alpha (TNFα)-induced transcription of TSLP. Chrysin attenuated TNFα-induced TSLP expression by downregulating EGR1 expression in HaCaT keratinocytes. We also showed that the oral administration of chrysin improved AD-like skin lesions in the ear and neck of BALB/c mice challenged with 2,4-dinitrochlorobenzene. We also showed that chrysin suppressed the expression of EGR1 and TSLP by inhibiting the extracellular signal-regulated kinase (ERK) 1/2 and c-Jun N-terminal kinase (JNK) 1/2 mitogen-activated protein kinase pathways. Collectively, the findings of this study suggest that chrysin improves AD-like skin lesions, at least in part, through the downregulation of the ERK1/2 or JNK1/2-EGR1-TSLP signaling axis in keratinocytes.

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Section: Discussionmentioning

confidence: 99%

Chrysin Inhibits TNFα-Induced TSLP Expression through Downregulation of EGR1 Expression in Keratinocytes

Yeo

Lee

Ahn

et al. 2021

IJMS

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“…The prognostic values of EGR1-4 showed a positive relationship with better RFS of BRCA patients. Although accumulating evidences con rm EGRs regulate the initiation and/or development of multiple cancers, the expression pro le and prognostic value of EGR1-4 and the role of EGR1 in BRCA remain unclear [9,26]. According to experiment validations, our investigations found that EGR1 protein was highly expressed and resisted cell migration in BRCA.…”

Section: Discussionmentioning

confidence: 68%

“…EGR1 acts as an anti-oncogene engaging in multiple cancer processes, including cancer cell proliferation, apoptosis, migration and even affects tumor microenvironment [9,10]. EGR1 decreased cell growth through downregulating EPO-R transcription under hypoxia in non-small cell lung carcinoma [11].…”

Section: Introductionmentioning

confidence: 99%

The Role of Early Growth Response 1 in the Prognostic Value and Cell Migration of Breast Cancer

Hao

Huang

et al. 2021

Preprint

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Background: Early growth response family members (EGRs), EGR1-4, have increasingly attracted attention in multiple cancers. However, the exact expression patterns and prognostic values of EGRs in the progress of breast cancer (BRCA) remain largely unknown. Methods: The mRNA expression and prognostic characteristics of EGRs were examined by the Cancer Genome Atlas (TCGA), Oncomine and Kaplan-Meier plotter. Enrichment analyses were conducted based on protein-protein interaction (PPI) network. The Tumor Immune Estimation Resource (TIMER) database and MethSurv were further explored. The protein expression level of EGR1 and cell migration were measured by Western blotting, immunohistochemistry, wound-healing assay and Boyden chamber assay in BRCA. Results: The transcriptional levels of EGR1/2/3 displayed significantly low expression in BRCA compared to that in normal tissues, while EGR4 was shown adverse expression pattern. Survival analysis revealed up-regulated EGR1-4 were remarkably associated with favorable relapse-free survival (RFS). A close correlation with specific tumor-infiltrating immune cells (TIICs) and several CpG sites of EGRs were exhibited. Immunohistochemistry assays showed that the protein expression of EGR1 was remarkably downregulated in BRCA compared to that in paracancerous tissues. Cell migration of MCF10A cells was increased after the silence of EGR1 by siRNA transfection.Conclusions: This study provides a novel insight to the role of EGR1 in the prognostic value and cell migration of BRCA.

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“…The prognostic values of EGR1–4 showed a positive relationship with better RFS of BRCA patients. Although accumulating evidences confirm EGRs regulate the initiation and/or development of multiple cancers, the expression profile and prognostic value of EGR1–4 and the role of EGR1 in BRCA remain unclear ( Suzuki et al, 2007 ; Li et al, 2019 ). According to experiment validations, our investigations found that EGR1 protein was highly expressed in paracancerous tissue and resisted the migration of MCF10A cells.…”

Section: Discussionmentioning

confidence: 99%

“…EGR1 acts as an anti-oncogene engaging in multiple cancer processes, including cancer cell proliferation, apoptosis, and migration and even affects tumor microenvironment ( Li et al, 2019 ; Tang et al, 2019 ). EGR1 decreased cell growth through downregulating EPO-R transcription under hypoxia in non-small cell lung carcinoma ( Su et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

The Role of Early Growth Response Family Members 1–4 in Prognostic Value of Breast Cancer

Hao

Huang

et al. 2021

Front. Genet.

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Early growth response family members (EGRs), EGR1–4, have increasingly attracted attention in multiple cancers. However, the exact expression patterns and prognostic values of EGRs in the progress of breast cancer (BRCA) remain largely unknown. The mRNA expression and prognostic characteristics of EGRs were examined by the Cancer Genome Atlas (TCGA), Oncomine, and Kaplan-Meier plotter. Enrichment analyses were conducted based on protein-protein interaction (PPI) network. The Tumor Immune Estimation Resource (TIMER) database and MethSurv were further explored. The protein expression of EGR1 in BRCA was measured by western blotting and immunohistochemistry. The migration of mammary epithelial cells was determined by Boyden chamber assay. The transcriptional levels of EGR1/2/3 displayed significantly low expression in BRCA compared with that in normal tissues, while EGR4 was shown adverse expression pattern. Survival analysis revealed upregulated EGR1–4 were remarkably associated with favorable relapse-free survival (RFS). A close correlation with specific tumor-infiltrating immune cells (TIICs) and several CpG sites of EGRs were exhibited. Immunohistochemistry assays showed that the protein expression of EGR1 was remarkably downregulated in BRCA compared with that in paracancerous tissues. The migration of MCF10A mammary epithelial cells was increased after the silence of EGR1 by siRNA transfection. This study provides a novel insight to the role of EGRs in the prognostic value of BRCA.

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Friend or foe, the role of EGR-1 in cancer

Cited by 53 publications

References 73 publications

Chrysin Inhibits TNFα-Induced TSLP Expression through Downregulation of EGR1 Expression in Keratinocytes

Chrysin Inhibits TNFα-Induced TSLP Expression through Downregulation of EGR1 Expression in Keratinocytes

The Role of Early Growth Response 1 in the Prognostic Value and Cell Migration of Breast Cancer

The Role of Early Growth Response Family Members 1–4 in Prognostic Value of Breast Cancer

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