From allergy to schistosomes: role of Fc receptors and adhesion molecules in eosinophil effector function

Nutten, Sophie; Trottein, François; Gounni, Abdelilah Soussi; Papin, Jean-Paul; Càpron, André; Capron, Moníque

doi:10.1590/s0074-02761997000800003

Cited by 9 publications

(5 citation statements)

References 29 publications

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“…Although the degranulation of eosinophil cells obviously occurred in toxocariasis patients, any ADCC killing mechanism involving both eosinophil and specific IgE does not seem to exist here, unlike that reported in mansoni schistosomiasis (Nutten et al, 1997). No correlation was found between ECP and specific anti-Toxocara IgE levels, a point that supports two explanatory hypotheses.…”

Section: Discussionsupporting

confidence: 57%

Eosinophil cationic protein, specific IgE and IgG4 in human toxocariasis

et al. 2006

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Among 67 French patients presenting a toxocaral infection, various demographic, environmental, clinical and laboratory parameters (blood eosinophil count, eosinophil cationic protein (ECP), serum total IgE, specific IgE against common inhalant allergens, specific IgE and IgG4 against Toxocara excretory-secretory antigens) were investigated. Correlation studies and logistic regression analyses were conducted, testing elevated levels of ECP, specific anti-Toxocara IgE or IgG4 as outcome variables An elevated ECP level was significantly associated with both cough and rhinitis, a high level of specific anti-Toxocara IgE with itchy rashes and possible atopic status, and an increase of specific anti-Toxocara IgG4 with rural residence.

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Section: Discussionsupporting

confidence: 57%

Eosinophil cationic protein, specific IgE and IgG4 in human toxocariasis

et al. 2006

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“…The sporadic presence of eosinophils in high numbers has been noted in previous studies of NCC patients (11). It contrasts with the predominance of this cell type in pigs that are naturally infected with T. solium metacestodes or with what is observed in other peripheral helminthic infections like schistosomiasis and filariasis in humans (1,9,25). Neutrophils were mostly located in the lumen of the vessels.…”

Section: Vol 69 2001mentioning

confidence: 61%

Brain Granulomas in Neurocysticercosis Patients Are Associated with a Th1 and Th2 Profile

et al. 2001

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Neurocysticercosis (NCC) is a common central nervous system (CNS) infection caused by Taenia solium metacestodes. Despite the well-documented importance of the granulomatous response in the pathogenesis of this infection, there is limited information about the types of cells and cytokines involved. In fact, there has been limited characterization of human brain granulomas with any infectious agent. In the present study a detailed histological and immunohistochemical analysis of the immune response was performed on eight craniotomy specimens where a granuloma surrounded each T. solium metacestode. The results indicated that in all the specimens there was a dying parasite surrounded by a mature granuloma with associated fibrosis, angiogenesis, and an inflammatory infiltrate. The most abundant cell types were plasma cells, B and T lymphocytes, macrophages, and mast cells. Th1 cytokines were prevalent and included gamma interferon, interleukin-18 (IL-18), and the immunosuppressive, fibrosis-promoting cytokine transforming growth factor ␤. The Th2 cytokines IL-4, IL-13, and IL-10 were also present. These observations indicate that a chronic immune response is elicited in the CNS environment with multiple cell types that together secrete inflammatory and anti-inflammatory cytokines. In addition, both collagen type I and type III deposits were evident and could contribute to irreversible nervous tissue damage in NCC patients.

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“…It might be confined to the inner bilayer of the surface membrane or buried in the glycocalyx. In the schistosomulum, both LeX and a selectin have been detected on the surface (Nutten et al 1997).…”

Section: The Organization Of Proteins and Lipids In The Bilayersmentioning

confidence: 99%

The schistosome in the mammalian host: understanding the mechanisms of adaptation

2007

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In this review, we envisage the host environment, not as a hostile one, since the schistosome thrives there, but as one in which the relationship between the two organisms consists of constant communication, through signalling mechanisms involving sense organs, surface glycocalyx, surface membrane and internal organs of the parasite, with host fluids and cells. The surface and secretions of the schistosome egg have very different properties from those of other parasite stages, but adapted for the dispersal of the eggs and for the preservation of host liver function. We draw from studies of mammalian cells and other organisms to indicate how further work might be carried out on the signalling function of the surface glycocalyx, the raft structure of the surface and existence of pores in the surface membrane, the repair of the surface membrane, the role of the membrane structure in ion channel function (including recent work on the actin cytoskeleton and calcium channels) and the possible role of P-glycoproteins in the adaptation of the parasite to its environment. We are speculative in some areas, such as the suggestions that variability in surface properties of schistosomes may relate to the existence of membrane rafts and that parasite communities may exhibit quorum sensing. This speculative approach is adopted with the hope that future work on the whole organisms and their interactions will be encouraged.

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From allergy to schistosomes: role of Fc receptors and adhesion molecules in eosinophil effector function

Cited by 9 publications

References 29 publications

Eosinophil cationic protein, specific IgE and IgG4 in human toxocariasis

Eosinophil cationic protein, specific IgE and IgG4 in human toxocariasis

Brain Granulomas in Neurocysticercosis Patients Are Associated with a Th1 and Th2 Profile

The schistosome in the mammalian host: understanding the mechanisms of adaptation

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