From atopic dermatitis to asthma: The risk factors and preventive measures

Businco, L; Falconieri, P.; Rienzo, A Di; Bruno, G

doi:10.1002/ppul.1950230810

Cited by 5 publications

(1 citation statement)

References 8 publications

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“…Eczema is the most common inflammatory skin disease in early childhood and is often the first manifestation for the so-called “atopic march” including food allergy, asthma and allergic rhinitis (1 – 5). Although genetic predisposition and allergic sensitization of infants to environmental factors are known to affect the onset and severity of eczema, a reported rise in allergy over the last several decades suggests an important role for the environment in the pathogenesis of infantile eczema (6 – 10).…”

Section: Introductionmentioning

confidence: 99%

Effect of prenatal exposure to fine particulate matter and intake of Paracetamol (Acetaminophen) in pregnancy on eczema occurrence in early childhood

Jędrychowski

Spengler

Maugeri³

et al. 2011

Science of The Total Environment

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Prenatal Paracetamol (Acetaminophen) has been associated with increased risk of allergic disease in early childhood, an association that could be due to increased altered susceptibility induced by air pollutants. The main goal of the study was to test the hypothesis that prenatal Paracetamol exposure increases the risk of developing eczema in early childhood and that this association is stronger for children who are exposed prenatally to higher concentrations of fine particulate matter (PM2.5). The study sample consisted of 322 women recruited from January 2001 to February 2004 in the Krakow inner city area who gave birth to term babies and completed 5-year follow-up. Paracetamol use in pregnancy was collected by interviews and prenatal personal exposure to over 48 hours was measured in all recruited women in the second trimester of PM2.5 pregnancy. After delivery, every three months in the first 24 months of the newborn’s life and every 6 months later, a detailed standardized face-to-face interview on the infant’s health was administered to each mother by a trained interviewer. During the interviews at each of the study periods after birth, a history of eczema was recorded. By Cox proportional hazard regression, prenatal exposure to Paracetamol increased the risk of eczema by 20% and PM2.5 by 6%, albeit non significantly. However, the the joint exposure to Paracetamol and higher prenatal PM2.5 was significant and doubled the risk of eczema symptoms (HR = 2.07, 95%CI: 1.01 – 4.34). The findings suggest that even very small doses of Paracetamol in pregnancy may affect the occurrence of allergy outcomes such as eczema in early childhood but only at the co-exposure to higher fine particulate matter.

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