Various texture, shape, boundary features have been used previously to classify regions of interest in radiological mammograms into normal and abnormal categories. Although, bag-ofphrases or n-gram model has been effective in text representation for classification or retrieval of text, these approaches have not been widely explored for medical image processing. Our purpose is to represent regions of interest using an n-gram model, then deploy the n-gram features into a back-propagation trained neural network for classifying regions of interest into normal and abnormal categories. Experiments on the benchmark miniMIAS database show that