From Conventional Radiotracer Tc-99m with Blue Dye to Indocyanine Green Fluorescence: A Comparison of Methods Towards Optimization of Sentinel Lymph Node Mapping in Early Stage Cervical Cancer for a Laparoscopic Approach

Buda, Alessandro; Papadia, Andrea; Zapardiel, Ignacio; Vizza, Enrico; Ghezzi, Fabio; Ponti, Elena De; Lissoni, Andrea Alberto; Imboden, Sara; Diestro, María Dolores; Verri, Debora; Gasparri, Maria Luisa; Bussi, Beatrice; Martino, Giampaolo Di; Noval, Begoña Díaz de la; Mueller, Michael D.; Crivellaro, Cinzia

doi:10.1245/s10434-016-5227-y

Cited by 68 publications

(60 citation statements)

References 29 publications

(29 reference statements)

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“…The greatest advantage of the ICG fluorescence imaging system is that it allows visualization of SN and afferent lymphatic vessels from primary tumor sites more clearly than a conventional dye approach based on visual recognition without special tools. To date, several investigators have demonstrated the clinical benefit of the ICG fluorescence imaging approach for SN detection in patients with several malignancies, including gastric cancer 16, 17, 18, 19…”

Section: A Novel Imaging System Developed For Sn Detectionmentioning

confidence: 99%

Novel surgical approach based on the sentinel node concept in patients with early gastric cancer

Natsugoe

Arigami

Uenosono

et al. 2017

Annals of Gastroent Surgery

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Recent prospective multicenter trials have demonstrated the clinical safety and efficacy of sentinel node navigation surgery (SNNS) in patients with early gastric cancer. Further, development of an intraoperative imaging system and an indocyanine green fluorescence imaging approach has been attracting attention as a novel tool for detection of the sentinel node (SN). The greatest advantage of an in vivo imaging system is that it visualizes SN and afferent lymphatic vessels from the primary tumor site more clearly than the conventional dye approach. Besides visualization of the SN, it is also essential to accurately assess the presence or absence of lymph node metastasis in the intraoperative management of SNNS. However, the clinical significance of lymph node micrometastasis (LNM) in patients with gastric cancer remains controversial. Reverse transcription‐polymerase chain reaction (RT‐PCR) is one of the representative assays used to identify LNM. A rapid RT‐PCR assay that completes the detection of LNM within approximately 40 minutes has recently been produced and applied in the clinical management of SNNS. From the viewpoint of surgical methods, modified laparoscopic and endoscopic cooperative surgery with non‐exposed approaches has recently been highlighted as a promising technique to prevent tumor dissemination caused by surgical procedures, and is likely to be clinically applied to SNNS in the future. When carrying out SNNS as a minimally invasive surgery, it is important to consider the balance between post‐surgical quality of life and curability. Future prospective studies on SNNS will greatly contribute to furthering its establishment as a beneficial procedure for patients with early gastric cancer.

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Section: A Novel Imaging System Developed For Sn Detectionmentioning

confidence: 99%

Novel surgical approach based on the sentinel node concept in patients with early gastric cancer

Natsugoe

Arigami

Uenosono

et al. 2017

Annals of Gastroent Surgery

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“…Nodal staging with an intracervical injection of ICG has also been established as accurate, safe, and reproducible in patients with cervical cancer 8,9…”

Section: Resultsmentioning

confidence: 99%

Sentinel Lymph Nodes Mapping in Cervical Cancer a Comprehensive Review

Diab¹

2016

Int J Gynecol Cancer

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ObjectiveA comprehensive literature search for more recent studies pertaining to sentinel lymph node mapping in the surveillance of cervical cancer to assess if sentinel lymph node mapping has sensitivity and specificity for evaluation of the disease; assessment of posttreatment response and disease recurrence in cervical cancer.Materials and MethodsThe literature review has been constructed on a step wise study design that includes 5 major steps. This includes search for relevant publications in various available databases, application of inclusion and exclusion criteria for the selection of relevant publications, assessment of quality of the studies included, extraction of the relevant data and coherent synthesis of the data.ResultsThe search yielded numerous studies pertaining to sentinel lymph node mapping, especially on the recent trends, comparison between various modalities and evaluation of the technique. Evaluation studies have appraised high sensitivity, high negative predictive values and low false-negative rate for metastasis detection using sentinel lymph node mapping. Comparative studies have established that of all the modalities for sentinel lymph node mapping, indocyanine green sentinel lymph node mapping has higher overall and bilateral detection rates. Corroboration of the deductions of these studies further establishes that the sentinel node detection rate and sensitivity are strongly correlated to the method or technique of mapping and the history of preoperative neoadjuvant chemotherapy.ConclusionsThe review takes us to the strong conclusion that sentinel lymph node mapping is an ideal technique for detection of sentinel lymph nodes in cervical cancer patients with excellent detection rates and high sensitivity. The review also takes us to the supposition that a routine clinical evaluation of sentinel lymph nodes is feasible and a real-time florescence mapping with indocyanine green dye gives better statistically significant overall and bilateral detection than methylene blue.

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“…Overall ICG remains a very safe product that performs better than the other conventional tracers (such as Tc-99m and blue dyes alone or in combination) when adopted for the SLN mapping in gynecologic oncology [2][3][4][5][6]8]. Although adverse reactions resulting from an intravenous or an interstitial injection of ICG are expected to be the same, since ICG has only been approved by FDA for intravenous injection, it is crucial to inform the patients undergoing SLN mapping on its off-label use as adverse reactions may otherwise lead to unpleasant medico-legal consequences.…”

Section: Discussionmentioning

confidence: 99%

“…This allows for an easy identification of the SLN. In gynecologic oncology this tracer has proven to be at least equivalent to the combination of technetium-99m Tc-99m and blue dyes as far as detection rates goes [2][3][4][5][6]. ICG seems to perform better in obese patients and is user friendlier as it does not require a preoperative intracervical injection as is the case with Tc-99m.…”

Section: Introductionmentioning

confidence: 99%

Are allergic reactions to indocyanine green really that uncommon? A single institution experiences

Papadia¹,

Gasparri²,

Mueller³

2017

Obstet Gynecol Rep

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From Conventional Radiotracer Tc-99m with Blue Dye to Indocyanine Green Fluorescence: A Comparison of Methods Towards Optimization of Sentinel Lymph Node Mapping in Early Stage Cervical Cancer for a Laparoscopic Approach

Cited by 68 publications

References 29 publications

Novel surgical approach based on the sentinel node concept in patients with early gastric cancer

Novel surgical approach based on the sentinel node concept in patients with early gastric cancer

Sentinel Lymph Nodes Mapping in Cervical Cancer a Comprehensive Review

Are allergic reactions to indocyanine green really that uncommon? A single institution experiences

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