2024
DOI: 10.1017/s0033583523000045
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From covalent transition states in chemistry to noncovalent in biology: from β- to Φ-value analysis of protein folding

Alan R. Fersht

Abstract: Solving the mechanism of a chemical reaction requires determining the structures of all the ground states on the pathway and the elusive transition states linking them. 2024 is the centenary of Brønsted’s landmark paper that introduced the β-value and structure-activity studies as the only experimental means to infer the structures of transition states. It involves making systematic small changes in the covalent structure of the reactants and analysing changes in activation and equilibrium-free energies. Prote… Show more

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Cited by 3 publications
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