sensors has become a cross-disciplinary field that integrates a wide range of expertise in electronics, physics, materials science, chemistry, and biology. [2] At the same time, significant breakthroughs in flexible electronics, nanotechnology, and manufacturing have enabled the construction of tactile sensors with superior performance based on different transduction methods, including piezoresistivity, [3] capacitance, [4] and piezoelectricity. [5] More specifically, large-scale skin-like tactile sensors that detect pressure, temperature, or other stimuli in the surroundings have attracted increasing attention for applications in human-machine interfaces, [6] intelligent robots, [7] artificial limbs, [8] and other intelligent systems. [9] However, certain challenges remain in large-scale tactile simulation with fast data transmission and low signal crosstalk among the pixels.The tactile sensor arrays based on a transistor matrix (TSATM) have thus been developed for large-scale 2D tactile profiles. [10] The field effect transistor (FET) is one of the most important components in every electronic device, and it has three lead-out electrodes, the source, drain, and gate electrodes. It can control the flow of electrons through a planar channel when the applied gate voltage exceeds a certain threshold. In this way, small changes in the input voltage can excite the transition between high and low output currents. Thus, the FET operates as a control device and amplifier in a logic circuit. [11] A transistor active matrix is necessary to be employed in a largescale tactile sensor, where the addressing mode is similar to the memory structure, with word lines and bit lines. Large-scale tactile mapping can be easily achieved by monitoring the drain/ source current of each pixel. At the same time, the one-way current-passing characteristics of the transistor make it possible to reduce the crosstalk among the pixels. Recently, various types of TSATMs with outstanding performance based on an integrated composite structure or intrinsic pressure sensitive transistor were consecutively demonstrated for a variety of actual applications, as shown in Figure 1.This review focuses on the introduction of advanced TSATMs. The main content includes the following aspects: i) various types of TSATMs with an integrated composite structure that consists of a transistor matrix and a pressuredependent electronic component, and the development of the Tactile sensors that possess the physical properties of human epidermis, which can sense external stimuli (pressure, temperature, humidity, etc.), are a very popular cutting-edge innovation. They make a large contribution to extensive applications in the real-time monitoring of human health, artificial intelligence, robot systems, and biocompatibility. However, great challenges remain in large-scale tactile simulation to attain fast data transmission and low signal crosstalk among the pixels. The tactile sensor arrays based on a transistor matrix (TSATMs) are thus investigated for large-sc...