From molecular action to physiological outputs: Peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions

Feige, Jérôme N.; Gelman, Laurent; Michalik, Liliane; Desvergne, Béatrice; Wahli, Walter

doi:10.1016/j.plipres.2005.12.002

Cited by 703 publications

(616 citation statements)

References 332 publications

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“…A small number of transcription factors have been recently identified that could be implicated in directing the phenotype of striated muscle fibers. They are as diverse as SIX1, for the specification of fast-glycolytic myofibers (Grifone et al, 2004), BERF1 that inhibits ␤-enolase expression in slow-oxidative myofibers (Passantino et al, 1998), PPAR␦ implicated in mitochondrial oxidative metabolism (Feige et al, 2006) and HIF-1␣ involved in the response to hypoxia and controlling glycolytic metabolism (Semenza, 1999). Work is in progress in our laboratory designed to manipulate the expression of such factors in the 9.…”

Section: Discussionmentioning

confidence: 99%

Novel murine clonal cell lines either express slow or mixed (fast and slow) muscle markers following differentiation in vitro

Peltzer

Colman

Cebrián

et al. 2008

Developmental Dynamics

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We have investigated whether the phenotype of myogenic clones derived from satellite cells of different muscles from the transgenic immortomouse depended on muscle type origin. Clones derived from neonatal, or 6-to 12-week-old fast and slow muscles, were analyzed for myosin and enolase isoforms as phenotypic markers. All clones derived from slow-oxidative muscles differentiated into myotubes with a preferentially slow contractile phenotype, whereas some clones derived from rapid-glycolytic or neonatal muscles expressed both fast and slow myosin isoforms. Thus, muscle origin appears to bias myosin isoform expression in myotubes. The neonatal clone (WTt) was cultivated in various medium and substrate conditions, allowing us to determine optimized conditions for their differentiation. Matrigel allowed expressions of adult myosin isoforms, and an isozymic switch from embryonic ␣-toward muscle-specific ␤-enolase, never previously observed in vitro. These cells will be a useful model for in vitro studies of muscle fiber maturation and plasticity.

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Section: Discussionmentioning

confidence: 99%

Novel murine clonal cell lines either express slow or mixed (fast and slow) muscle markers following differentiation in vitro

Peltzer

Colman

Cebrián

et al. 2008

Developmental Dynamics

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“…Nuclear receptor activity and function is modified by ligand-binding, post-translational modifications and by association with various co-repressors and co-activators (Tan et al, 2005;Feige et al, 2006). Ligand binding of PPARa and PPARb/d increases FA oxidation, and ligand binding of PPARg increases FA transport and lipogenesis; none of these changes are consistent with the phenotype of MFD.…”

Section: Sterol Response Element-binding Protein-1mentioning

confidence: 99%

Recent advances in the regulation of milk fat synthesis

Harvatine

Boisclair

Bauman

2009

Animal

268

272

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In addition to its economic value, milk fat is responsible for many of milk's characteristics and can be markedly affected by diet. Diet-induced milk fat depression (MFD) was first described over a century ago and remains a common problem observed under both intensive and extensive management. The biohydrogenation theory established that MFD is caused by an inhibition of mammary synthesis of milk fat by specific fatty acids (FA) produced as intermediates in ruminal biohydrogenation. During MFD, lipogenic capacity and transcription of key lipid synthesis genes in the mammary gland are down-regulated in a coordinated manner. Our investigations have established that expressions of sterol response element-binding protein 1 (SREBP1) and SREBP-activation proteins are down-regulated during MFD. Importantly, key lipogenic enzymes are transcriptionally regulated via SREBP1. Collectively, these results provide strong evidence for SREBP1 as a central signaling pathway in the regulation of mammary FA synthesis. Spot 14 is also down-regulated during MFD, consistent with a lipogenic role for this novel nuclear protein. In addition, SREBP1c and Spot 14 knock-out mice exhibit reduced milk fat similar to the magnitude and pattern of MFD in the cow. Application of molecular biology approaches has provided the latest chapter in the regulation of milk fat synthesis and is reviewed along with a brief background in nutritional regulation of milk fat synthesis in ruminants.

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“…PPARs are ligand-activated transcription factors belonging to the nuclear hormone receptor super-family [4]. The name PPAR derives from the ability of the first identified PPARs possess the classic domain structure of nuclear receptors [4].…”

Section: The Ppar Familymentioning

confidence: 99%

PPARs and adipocyte function

Christodoulides

Vidal-Puig

2010

Molecular and Cellular Endocrinology

115

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Abstract:For long viewed as passive lipid storage depots, adipocytes are now recognised as key players in the pathogenesis of insulin resistance and metabolic disease. In parallel, the last two decades of research have seen the emergence of transcription factors of the peroxisome proliferator-activated receptor (PPAR) family as central regulators of lipid and glucose homeostasis and molecular targets for drugs to treat hyper-lipidaemia and type 2 diabetes mellitus. In this review we discuss the characteristics of PPARs and the role of the different isotypes in adipocyte biology.

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From molecular action to physiological outputs: Peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions

Cited by 703 publications

References 332 publications

Novel murine clonal cell lines either express slow or mixed (fast and slow) muscle markers following differentiation in vitro

Novel murine clonal cell lines either express slow or mixed (fast and slow) muscle markers following differentiation in vitro

Recent advances in the regulation of milk fat synthesis

PPARs and adipocyte function

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