From neuron to behavior: Sensory‐motor coordination of zebrafish turning behavior

Umeda, Keiko; Watanabe, Shôji

doi:10.1111/dgd.12345

Cited by 12 publications

(4 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the zebrafish brain stem, Mauthner cells, a type of reticulospinal (RS) neuron, form synaptic contacts with trunk motor neurons and can initiate the C-shaped turning, a fast escape reflex. Damage to neurons of the brain could alter hormone production pathways and eventually affect the coiling behavior (Jontes et al, 2000;Umeda and Shoji, 2017). In the present study, 6-OH-BDE-47 exposed embryos had significantly more apoptotic cells compared to controls.…”

Section: Discussionsupporting

confidence: 42%

Increased coiling frequency linked to apoptosis in the brain and altered thyroid signaling in zebrafish embryos (Danio rerio) exposed to the PBDE metabolite 6-OH-BDE-47

et al. 2018

View full text Add to dashboard Cite

Polybrominated diphenyl ethers (PBDEs) are a group of brominated flame retardants that are ubiquitously detected in the environment and associated with adverse health outcomes. 6-OH-BDE-47 is a metabolite of the flame retardant, 2,2',4,4'-Tetrabromodiphenyl ether (BDE-47), and there is increasing concern regarding its developmental neurotoxicity and endocrine disrupting properties. In this study, we report that early life exposure in zebrafish (Danio rerio) embryos to 6-OH-BDE-47 (50 and 100 nM) resulted in higher coiling frequency and significantly increased apoptotic cells in the brain. These effects were partially rescued by overexpression of thyroid hormone receptor β (THRβ) mRNA. Moreover, exposure to 100 nM 6-OH-BDE-47 significantly reduced the number of hypothalamic 5-hydroxytryptamine (5-HT, serotonin)-immunoreactive (5-HT-ir) neurons and the mRNA expression of tryptophan hydroxylase 2 (TPH2). These results indicate that 6-OH-BDE-47 affected thyroid hormone regulation through THRβ and negatively impacted the nervous system, in turn, affecting coiling behavior. Correlations of these endpoints suggest that coiling frequency could be used as an indicator of neurotoxicity in embryos.

show abstract

Section: Discussionsupporting

confidence: 42%

Increased coiling frequency linked to apoptosis in the brain and altered thyroid signaling in zebrafish embryos (Danio rerio) exposed to the PBDE metabolite 6-OH-BDE-47

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Understanding the neuronal encoding and decoding of sensory information in aquatic and aerial animals is an active area of research in neuroscience (see, e.g. [31][32][33][34] and references therein). For example, several studies focus on deciphering the sensori-motor pathways, motor response to sensory stimulus, in specific animal models, such as the zebrafish Danio reriozebra [35,36] and the Drosophila fly, [37,38].…”

Section: Introductionmentioning

confidence: 99%

Training bioinspired sensors to classify flows

2018

View full text Add to dashboard Cite

We consider the inverse problem of classifying flow patterns from local sensory measurements. This problem is inspired by the ability of various aquatic organisms to respond to ambient flow signals, and is relevant for translating these abilities to underwater robotic vehicles. In Colvert, Alsalman and Kanso, B&B (2018), we trained neural networks to classify vortical flows by relying on a single flow sensor that measures a 'time history' of the local vorticity. Here, we systematically investigate the effects of distinct types of sensors on the accuracy of flow classification. We consider four types of sensors-vorticity, flow velocities parallel and transverse to the direction of flow propagation, and flow speed-and show that the networks trained using transverse velocity outperform other networks, even when subjected to aggressive data corruption. We then train the network to classify flow patterns instantaneously, using a spatially-distributed array of sensors and a single 'one time' sensory measurement. The network, based on a handful of spatially-distributed sensors, exhibits remarkable accuracy in flow classification. These results lay the groundwork for developing learning algorithms for the dynamic deployment of sensory arrays in unsteady flows.

show abstract

“…Locomotor activity of larval zebrafish is relatively well studied [49][50][51][52]; however, the metrics describing adult zebrafish behavior are scarce. Previous studies have used swimming speed and preference index to quantify odordriven behaviors.…”

Section: Metrics For Adult Zebrafish Behaviormentioning

confidence: 99%

Stimulus-specific behavioral responses of zebrafish to a large range of odors exhibit individual variability

et al. 2020

View full text Add to dashboard Cite

Background: Odor-driven behaviors such as feeding, mating, and predator avoidance are crucial for animal survival. The neural pathways processing these behaviors have been well characterized in a number of species, and involve the activity of diverse brain regions following stimulation of the olfactory bulb by specific odors. However, while the zebrafish olfactory circuitry is well understood, a comprehensive characterization linking odor-driven behaviors to specific odors is needed to better relate olfactory computations to animal responses. Results: Here, we used a medium-throughput setup to measure the swimming trajectories of 10 zebrafish in response to 17 ecologically relevant odors. By selecting appropriate locomotor metrics, we constructed ethograms systematically describing odor-induced changes in the swimming trajectory. We found that adult zebrafish reacted to most odorants using different behavioral programs and that a combination of a few relevant behavioral metrics enabled us to capture most of the variance in these innate odor responses. We observed that individual components of natural food and alarm odors do not elicit the full behavioral response. Finally, we show that zebrafish blood elicits prominent defensive behaviors similar to those evoked by skin extract and activates spatially overlapping olfactory bulb domains. Conclusion: Altogether, our results highlight a prominent intra-and inter-individual variability in zebrafish odordriven behaviors and identify a small set of waterborne odors that elicit robust responses. Our behavioral setup and our results will be useful resources for future studies interested in characterizing innate olfactory behaviors in aquatic animals.

show abstract

From neuron to behavior: Sensory‐motor coordination of zebrafish turning behavior

Cited by 12 publications

References 31 publications

Increased coiling frequency linked to apoptosis in the brain and altered thyroid signaling in zebrafish embryos (Danio rerio) exposed to the PBDE metabolite 6-OH-BDE-47

Increased coiling frequency linked to apoptosis in the brain and altered thyroid signaling in zebrafish embryos (Danio rerio) exposed to the PBDE metabolite 6-OH-BDE-47

Training bioinspired sensors to classify flows

Stimulus-specific behavioral responses of zebrafish to a large range of odors exhibit individual variability

Contact Info

Product

Resources

About