1998
DOI: 10.1016/s1359-6446(98)01220-3
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From peptides to drugs via phage display

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Cited by 76 publications
(61 citation statements)
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“…It is believed that this method is more successful in identifying ligands against various proteins because the peptide ligands favor binding to recesses or cavities in the target proteins by displacing water molecules, and typically, such sites are biologically important (39). Our screening led to the identification of five peptide ligands against fB, but only one showed inhibition of fB activation at a high micromolar concentration (IC 50 = 56 mM) (Fig.…”
Section: Discussionmentioning
confidence: 98%
“…It is believed that this method is more successful in identifying ligands against various proteins because the peptide ligands favor binding to recesses or cavities in the target proteins by displacing water molecules, and typically, such sites are biologically important (39). Our screening led to the identification of five peptide ligands against fB, but only one showed inhibition of fB activation at a high micromolar concentration (IC 50 = 56 mM) (Fig.…”
Section: Discussionmentioning
confidence: 98%
“…This approach offers a direct way to assay for small molecules in the absence of structural, or practically any other information about the target protein. In addition, target validation can be conveniently done with the peptides before conducting large screening programs to search for the small-molecule compounds (Kay et al, 1998).…”
Section: Current Approaches To Increase the Chemical Diversity Of Biomentioning
confidence: 99%
“…rug development strategies for therapeutic peptides continue to be challenging despite advances in technologies such as pegylation and lipidation (1)(2)(3)(4). Although important biological processes are regulated by peptides, successful development of peptide drugs has been limited and transformation of a metabolically labile peptide into a drug remains challenging.…”
mentioning
confidence: 99%