From species differences to individual differences

Insel, Thomas R.

doi:10.1038/sj.mp.4001826

Cited by 5 publications

(3 citation statements)

References 7 publications

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“…A study by our group 46 showed association between the Autism Diagnostic Observation Schedule-Generic (ADOS-G), 47 a composite measure of autism deficits (especially social skills), and the microsatellite haplotypes of the AVPR1a receptor. This fits with Insel's previous findings, 48 which demonstrate that length of microsatellite repeats in the AVPR1a promoter region in the vole determine the brain expression patterns of this receptor and consequent behavioral profile. 49,50 Importantly, echoing the previous vole studies, our study underscores that the association with AVPR1a is likely mediated by deficits in social skill.…”

Section: Avpr1asupporting

confidence: 92%

Arginine Vasopressin and Oxytocin Modulate Human Social Behavior

Ebstein

Israel

Lerer

et al. 2009

Annals of the New York Academy of Sciences

174

114

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Increasing evidence suggests that two nonapeptides, arginine vasopressin and oxytocin, shape human social behavior in both nonclinical and clinical subjects. Evidence is discussed that in autism spectrum disorders genetic polymorphisms in the vasopressin-oxytocin pathway, notably the arginine vasopressin receptor 1a (AVPR1a), the oxytocin receptor (OXTR), neurophysin I and II, and CD38 (recently shown to be critical for social behavior by mediating oxytocin secretion) contribute to deficits in socialization skills in this group of patients. We also present first evidence that CD38 expression in lymphoblastoid cells derived from subjects diagnosed with autism is correlated with social skill phenotype inventoried by the Vineland Adaptive Behavioral Scales. Additionally, we discuss molecular genetic evidence that in nonclinical subjects both AVPR1a and OXTR genes contribute to prosocial or altruistic behavior inventoried by two experimental paradigms, the dictator game and social values orientation. The role of the AVPR1a is also analyzed in prepulse inhibition. Prepulse inhibition of the startle response to auditory stimuli is a largely autonomic response that resonates with social cognition in both animal models and humans. First results are presented showing that intranasal administration of arginine vasopressin increases salivary cortisol levels in the Trier Social Stress test. To summarize, accumulating studies employing a broad array of cutting-edge tools in psychology, neuroeconomics, molecular genetics, pharmacology, electrophysiology, and brain imaging are beginning to elaborate the intriguing role of oxytocin and arginine vasopressin in human social behavior. We expect that future studies will continue this advance and deepen our understanding of these complex events.

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Section: Avpr1asupporting

confidence: 92%

Arginine Vasopressin and Oxytocin Modulate Human Social Behavior

Ebstein

Israel

Lerer

et al. 2009

Annals of the New York Academy of Sciences

174

114

View full text Add to dashboard Cite

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“…Higher systems integrate, elaborate, fine‐tune, and serve an inhibitory function for hierarchically lower systems. Converging evidence for the vertical‐integrative perspective emerges from functional, neurochemical, and imaging studies that indicate that functioning across a wide range of tasks and systems involves hierarchical and synchronous functioning at the brain stem, limbic, and cortical levels in both humans and primates (Caldji, Diorio, & Meaney, 2000; Damasio, 2003; Heim & Nemeroff, 2001; Insel, 2007; Swain, Lorberbaum, Kose, & Strathearn, 2007). These studies show that higher order abilities involving cortical activity require simultaneous processing and modulation at various locations along the neuroaxis.…”

mentioning

confidence: 99%

The Development of Regulatory Functions From Birth to 5 Years: Insights From Premature Infants

2009

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This study examined physiological, emotional, and attentional regulatory functions as predictors of self-regulation in 125 infants followed 7 times from birth to 5 years. Physiological regulation was assessed by neonatal vagal tone and sleep-wake cyclicity; emotion regulation by response to stress at 3, 6, and 12 months; and attention regulation by focused attention and delayed response in the 2nd year. Executive functions, behavior adaptation, and self-restraint were measured at 5 years. Regulatory functions showed stability across time, measures, and levels. Structural modeling demonstrated both mediated paths from physiological to self-regulation through emotional and attentional processes and direct continuity between vagal tone and each level of regulation. Results support the coherence of the regulation construct and are consistent with neurobiological models on self and consciousness.

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“…75 Devletçiliğin ilk yıllarında işletmeye açılan kuruluşlar genel olarak batılılaşma sürecinin hızlandırılması için de kullanılmış, devlet işletmelerinin etrafında inşa edilen tesisler ile modern Batı tarzı bir yaşamın topluma gösterilmesi ve iktisadi olarak kalkınma hedeflenmiştir. 76 Başgil bu noktada Anadolu'daki vaziyet karşısında toplumun her alanını baştan yaratmak ve ona yön vermenin gerekli olduğunu belirtmiştir. Ona göre bu noktada devletçilik, sadece iktisadi bir gelişme olmaktan ötedir.…”

Section: Türkiye'de Devletçilik Ve Uygulanmasıunclassified

Türkiye’de Devletçiliğin Ortaya Çıkışı ve Uygulanması Üzerine Ali Fuad Başgil ve Tarık Zafer Tunaya’nın Görüşleri

Öztürk¹

2020

Journal of History and Future

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From species differences to individual differences

Cited by 5 publications

References 7 publications

Arginine Vasopressin and Oxytocin Modulate Human Social Behavior

Arginine Vasopressin and Oxytocin Modulate Human Social Behavior

The Development of Regulatory Functions From Birth to 5 Years: Insights From Premature Infants

Türkiye’de Devletçiliğin Ortaya Çıkışı ve Uygulanması Üzerine Ali Fuad Başgil ve Tarık Zafer Tunaya’nın Görüşleri

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