From TELOCYTES to TELOCYTOPATHIES. Do Recently Described Interstitial Cells Play a Role in Female Idiopathic Infertility?

Klein, Martin; Lapides, Lenka; Fecmanová, Denisa; Varga, Ivan

doi:10.3390/medicina56120688

Cited by 7 publications

(2 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the key conundrum that has to be resolved is the correlation vs. causality issue. This is relevant since functional aberrations or quantitative TC decrease are mentioned in majority of studies that explore the role of TCs in disease development (14).…”

Section: Introductionmentioning

confidence: 99%

Stromal Hücrelerin Tarihçesi: İnterstisyel Cajal Hücrelerinden Telositlere - İnsan Telositlerine ve Olası İşlevlerine Kısa Bir Bakış

PURELKU,

TANRIVERDİ

2023

Ege Tıp Dergisi

View full text Add to dashboard Cite

In the organ microenvironment stromal cells make up an essential population, however research on them has been very limited. The stroma mainly consists of fibroblasts that reside together with mesenchymal cells, endothelial cells, pericytes, neurons, adipocytes, immune cells etc. The different morphologies and functional properties of stromal cells have led to subclassification of different cell types in connective tissue. Among them are the interstitial cells of Cajal and telocytes. Telocytes are one of the newer cells known for their small cell bodies and long telopods and have been recently identified in the connective tissue of many organs. Telocytes are strategically positioned near nerve endings, around blood capillaries and in close relation with particular cells. The network of telocytes is engaged in integrating information from multiple sources and coordinating the tissue homeostasis in response to the tissues local functional requirements. Extracellular vesicles provide a means of bidirectional communication, and their secretome appears to control the mechanisms of stem cell differentiation. Telocytes have been identified in various organs, specifically in human heart, lungs, brain, eye, thyroid, skeletal muscles, skin, salivary glands, gastrointestinal tract, pancreas, gallbladder, liver, and organs of the male and female urogenital system. Additionally, given the heterogeneity of the organs in which telocytes are found, and their capability to play a role in the etiopathogenesis of various diseases, the concept of "telocytopathies" has emerged. In conclusion, telocytes are increasingly becoming a focal point for the understanding of idiopathic diseases that affect humans as well as the development of new diagnostic and therapeutic approaches, and they have the potential to contribute to regenerative medicine.

show abstract

Section: Introductionmentioning

confidence: 99%

Stromal Hücrelerin Tarihçesi: İnterstisyel Cajal Hücrelerinden Telositlere - İnsan Telositlerine ve Olası İşlevlerine Kısa Bir Bakış

PURELKU,

TANRIVERDİ

2023

Ege Tıp Dergisi

View full text Add to dashboard Cite

show abstract

“…They can be identified by unique biomarker immunostaining and transmission electron microscopy scanning. Focusing on tumorigenesis, TCs were reported as an accelerative factor to promote the invasion and migration of cancer and cell proliferation (Klein et al, 2020). For instance, we demonstrated that when PDGF‐α stimulated TCs, the Raf/MEK/ERK signaling pathway was activated to increase MMP9 expression, which was a molecular mechanism by which TCs promote HCC metastasis (Xu et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

Matrix metalloproteinase gene mutations and bioinformatics of telocytes in hepatocellular carcinoma

Luan¹,

2022

Cell Biology International

View full text Add to dashboard Cite

Telocytes (TCs) have crucial functions to promote the metastasis of hepatocellular carcinoma (HCC) by over-expressing matrix metalloproteinases (MMPs), but the mechanism by which TCs secrete MMPs in the genome is still unknown. We first cultured and isolated primary TCs from distinct liver cancer tissues and hepatic hemangioma surrounding tissues (Control group). Their whole exon genes were tested by Illumina HiSeq family of platforms and by high-throughput sequencing as well as variant mutations. Moreover, immunohistochemistry, Western blot, and quantitative reverse transcription-polymerase chain reaction assays were utilized to assess the expression of MMPs. The perniciousness of signal-nucleotide polymorphism (SNP) mutations of proteins were predicted by the Polyphen-2 database. Divergent expression and overall survival (OS) of MMPs was screened by StarBase-Pan Cancer plate; and MMPs associated signaling pathways were found by Kyoto Encyclopedia Genes and Genomes. The "competing endogenous RNA (ceRNA)" network was constructed by Cytoscape software. We found that 12 specific types of SNP mutations related to 5

show abstract

Telocytes and endometriosis

Zhang

Zhu

2022

Arch Gynecol Obstet

View full text Add to dashboard Cite

From TELOCYTES to TELOCYTOPATHIES. Do Recently Described Interstitial Cells Play a Role in Female Idiopathic Infertility?

Cited by 7 publications

References 4 publications

Stromal Hücrelerin Tarihçesi: İnterstisyel Cajal Hücrelerinden Telositlere - İnsan Telositlerine ve Olası İşlevlerine Kısa Bir Bakış

Stromal Hücrelerin Tarihçesi: İnterstisyel Cajal Hücrelerinden Telositlere - İnsan Telositlerine ve Olası İşlevlerine Kısa Bir Bakış

Matrix metalloproteinase gene mutations and bioinformatics of telocytes in hepatocellular carcinoma

Telocytes and endometriosis

Contact Info

Product

Resources

About