Telocytes and endometriosis

Xu, Ting; Zhang, Hongqi; Zhu, Zhiling

doi:10.1007/s00404-022-06634-w

Cited by 9 publications

(5 citation statements)

References 90 publications

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“…TCs play a potential role in endometriosis by affecting the inflammatory response, invasion and angiogenesis and may be a potential therapeutic option for endometriosis. [63] TCs are involved in a range of inflammatory responses in addition to a variety of pathological processes, such as cancer cell invasion and metastasis, vascular regeneration, and fibrosis reversal. [64] A report has found a significant increase in the TC concentration in tissues of chronically injured patients compared to healthy controls, which reduced the delay in wound healing, and the inflammatory response induced by LPS can be mediated by inflammatory inhibition, thereby limiting apoptosis, promoting skin cell proliferation and migration, and accelerating inflammatory repair.…”

Section: Pathological Role Of Telocytesmentioning

confidence: 99%

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Telocytes and inflammation: A review

Zhang,

Tian

2023

Medicine

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Telocytes are a new type of interstitial cell with a diverse morphology and important functions, such as mechanical support, signal transduction, immune regulation, and tissue repair. In this paper, the origin and physiological and pathological functions of telocytes as well as their role in inflammation will be discussed, and the functions and targets of telocytes in inflammation will be fully reviewed, which may contribute to a new therapeutic strategy for inflammatory diseases in the future.

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Section: Pathological Role Of Telocytesmentioning

confidence: 99%

“…TCs play a potential role in endometriosis by affecting the inflammatory response, invasion and angiogenesis and may be a potential therapeutic option for endometriosis. [63]…”

Section: Pathological Role Of Telocytesmentioning

confidence: 99%

Telocytes and inflammation: A review

Zhang,

Tian

2023

Medicine

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“…Telocytes (TCs) are considered a distinct population of interstitial cells that have been discovered in the interstitium of organs and tissues of mammals including the respiratory system and multiple tumors. [1][2][3][4][5][6][7] Antitumor therapeutic resistance in non-small cell lung cancer could be promoted by epithelial-mesenchymal transition. Evasion of the immune system is an important step in the progression of malignancies, among which, T-cell immune escape and immunotherapeutic strategies were emphasized toward an antitumour immune response.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Single‐cell RNA sequencing reveals telocytes subsets of human lung

Dai,

Cai,

Wang

et al. 2024

Clinical and Translational Dis

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BackgroundTelocyte (TC) is a recently defined renewed cell and its dominant intercommunication with other cells displays multiple functions in tissue homeostasis and diseases. Alveolar epithelial cells and immune cells were in the lung cancer heterogeneity, progression, and metastasis, and further associated with antitumor therapeutic strategies. However, few studies focus on the roles of TCs in lung cancer.MethodsIn this article, we used the public scRNA‐Seq data (including healthy control, chronic obstructive pulmonary disease, non–small cell lung cancer, lymph node metastases from non–small cell lung cancer, and systemic sclerosis–associated interstitial lung disease patients) to analyze the cellular dynamics in human lung and distinct types of TCs and their communication networks with the variety of cell types.ResultsSix subclusters of TCs were identified by expression of specific biological function markers, which demonstrated the diversity of TCs subsets in lung tissue. Further results showed TCs had communication with epithelial cells or immune cells subsets by the ligand–receptor interaction, including TIMP metallopeptidase inhibitor 1CD63, fibulin 1integrin subunit beta 1, vimentinCD44, macrophage migration inhibitory factorCD74, and amyloid beta precursor proteinCD74. Ligand–receptor interaction heterogeneity was revealed in lung tissue of healthy or diseases. Enhanced specific signals in ligandreceptor interaction were revealed, including integrin beta 1 and CD44 were appraised in the communication of TCs with epithelial cells, NK cells, NKT cells, CD4+ exhausted T cells, CD4+ memory/effector T cells, CD4+ naïve T cells, CD8+ exhausted T cells, CD8+ memory/effector T cells, and CD8+ naïve T cells. CD63, a marker identified in TCs exosomes was emphasized in our current analysis which is closely related to communication of TCs with other cell types.ConclusionThese results will provide us with new insight into the mechanisms of TCs‐dominated communication and promise therapy of TC exosomes in lung diseases.

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“…A significant change is that TCs in the normal vascular wall, which express CD34, have the ability to transform into TCs expressing CD68 and matrix metalloproteinase-9 (MMP9) during tumor angiogenesis and proliferation processes. [ 13 ] The pivotal functions of TCs in TME have been reported, and this could potentially provide a strong basis for naming them as TATCs.…”

mentioning

confidence: 99%

Tumor-associated telocytes

Zhang,

2024

Chinese Medical Journal

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Telocytes and endometriosis

Cited by 9 publications

References 90 publications

Telocytes and inflammation: A review

Telocytes and inflammation: A review

Single‐cell RNA sequencing reveals telocytes subsets of human lung

Tumor-associated telocytes

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