From the Gut to the Heart: Campylobacter jejuni Enteritis Leading to Myopericarditis

Inayat, Faisal; Ali, Nouman Safdar; Riaz, Iqra; Virk, Hafeez Ul Hasan

doi:10.7759/cureus.1326

Cited by 7 publications

(19 citation statements)

References 8 publications

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“…Ang, Jacobs, and Laman (2004) considered ganglioside mimicry a crucial factor in pathogenesis of C. jejuni-associated GBS. Rare complications, for example, meningitis, recurrent colitis, acute cholecystitis, massive lower gastrointestinal haemorrhage, mesenteric adenitis, appendicitis and cardiac diseases, have also been reported (Hannu, Mattila, Rautelin, Siitonen, & Leirisalo-Repo, 2005;Inayat, Ali, Riaz, & Virk, 2017). Immunosuppressed individuals or others with coexisting conditions are at a high risk for severe or recurrent infections or for septicaemia (Greg, Mannino, Eaton, & Moss, 2003).…”

Section: Mechanisms Of the Agent Virulence-associated Markersmentioning

confidence: 99%

Knowledge gaps in control ofCampylobacterfor prevention of campylobacteriosis

Hansson

Sandberg

Habib

et al. 2018

Transbound Emerg Dis

146

112

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Campylobacteriosis is an important, worldwide public health problem with numerous socio-economic impacts. Since 2015, approximately 230,000 cases have been reported annually in Europe. In the United States, Australia and New Zealand, campylobacteriosis is the most commonly reported disease. Poultry and poultry products are considered important sources of human infections. Poultry meat can become contaminated with Campylobacter during slaughter if live chickens are intestinal carriers. Campylobacter spp. can be transferred from animals to humans through consumption and handling of contaminated food products, with fresh chicken meat being the most commonly implicated food type. Regarding food-borne disease, the most important Campylobacter species are Campylobacter jejuni and Campylobacter coli. In humans, clinical signs of campylobacteriosis include diarrhoea, abdominal pain, fever, headache, nausea and vomiting. Most cases of campylobacteriosis are sporadic and self-limiting, but there are post-infection complications, for example, Guillain-Barrés syndrome. This review summarizes an analysis undertaken by the DISCONTOOLS group of experts on campylobacteriosis. Gaps were identified in: (i) knowledge of true number of infected humans; (ii) mechanisms of pathogenicity to induce infection in humans; (iii) training to prevent transfer of Campylobacter from raw to ready-to-eat food; (iv) development of effective vaccines; (v) understanding transmission routes to broiler flocks; (vi) knowledge of bacteriocins, bacteriophages and antimicrobial peptides as preventive therapies; (vii) ration formulation as an effective preventive measure at a farm level; (viii) development of kits for rapid detection and quantification of Campylobacter in animals and food products; and (ix) development of more effective antimicrobials for treatment of humans infected with Campylobacter. Some of these gaps are relevant worldwide, whereas others are more related to problems encountered with Campylobacter in industrialized countries.

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Section: Mechanisms Of the Agent Virulence-associated Markersmentioning

confidence: 99%

Knowledge gaps in control ofCampylobacterfor prevention of campylobacteriosis

Hansson

Sandberg

Habib

et al. 2018

Transbound Emerg Dis

146

112

View full text Add to dashboard Cite

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“… 40 2011 Escherichia coli M 64 Fever, GE + – 3 Normal 0 – + 50 0 0 + 0 0 Urinary tract infection Probable Inayat et al. 41 2017 Campylobacter jejuni M 20 Fever, GE + 121 1300 Ripolarization abn. 0 + + 41 0 0 + 0 0 – Probable Hessulf et al.…”

Section: Resultsmentioning

confidence: 99%

“…The overall median LVEF at admission was 45%, 20 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 and patients with sepsis had significantly lower values (35% 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 vs 50% 39 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 ; (p < 0.001)).…”

Section: Resultsmentioning

confidence: 99%

Epidemiologic and clinical profiles of bacterial myocarditis. Report of two cases and data from a pooled analysis

Ferrero

Piazza

Lorini

et al. 2020

Indian Heart Journal

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We aimed to characterize the epidemiology, diagnostic peculiarities and outcome determinants of bacterial myocarditis. Two cases from our institution and literature reports were collected ending up with a total of 66 cases. In 37 (56%) patients, the diagnosis was confirmed by magnetic resonance and histopathological criteria. The other patients were classified as having possible myocarditis. Only occurrence of rhythm disturbances was associated with the specific diagnosis of myocarditis (p = 0.04). Thirty-two (48%) patients presented with severe sepsis that was associated with a worse prognosis. At multivariate analysis, left ventricular ejection fraction (LVEF) at admission and heart rhythm disturbances were associated with incomplete recovery (odds ratio (OR) 1.1, 95% (CI) 1.03–1.2, p = 0.004 and OR 6.6, 95% CI 1.35–32.5, p = 0.02, respectively). In summary, bacterial myocarditis is uncommon. Most commonly, it is secondary to septic dissemination of bacteria or to transient secondary myocardial toxicity.

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“…[2][3][4]8,9,12 In the current case, we considered it inappropriate to perform EBM owing to the patient's excellent general condition. Although cardiac magnetic resonance imaging has recently been used in the diagnosis or evaluation of myocarditis, including acute myocarditis associated with C jejuni infection, 5,6,9,[13][14][15] this method was not performed in the present case.…”

Section: Discussionmentioning

confidence: 99%

Relapse of acute myocarditis associated with Campylobacter jejuni enterocolitis

Yaita

Tago

Hisata

et al. 2020

Clinical Case Reports

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Campylobacter infection causes enterocolitis and may also cause various complications such as Guillain-Barré syndrome, reactive arthritis, inflammatory bowel disease, arteritis with aortic dissection, cholecystitis, and acute myocarditis. 1 Acute myocarditis associated with Campylobacter jejuni infection is common in males aged 10-49 years. The affected patients present 3-5 days after the onset of gastroenteritis with chest tightness, chest pain, dyspnea, abnormalities on electrocardiography (ECG), and elevated levels of serum myocardial enzymes. 2 The diagnosis of acute myocarditis associated with C jejuni infection is based on the detection of C jejuni in stool culture or a positive serum antibody titer. 1 Although the prognosis is usually good, there are some reports of mortality or residual mitral valve prolapse. 2,3 There has been no report of relapse of myocarditis associated with C jejuni during follow-up of several weeks. 2,4-6 We herein report the first case of acute relapse of myocarditis associated with C jejuni.

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From the Gut to the Heart: Campylobacter jejuni Enteritis Leading to Myopericarditis

Cited by 7 publications

References 8 publications

Knowledge gaps in control ofCampylobacterfor prevention of campylobacteriosis

Knowledge gaps in control ofCampylobacterfor prevention of campylobacteriosis

Epidemiologic and clinical profiles of bacterial myocarditis. Report of two cases and data from a pooled analysis

Relapse of acute myocarditis associated with Campylobacter jejuni enterocolitis

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