From theories of aging to anti-aging interventions

Moskalev, Alexey; Pasyukova, Elena G.

doi:10.3389/fgene.2014.00276

Cited by 11 publications

(9 citation statements)

References 20 publications

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“…While these uncertainties loom large now, they could be obviated by the advent of game-changing medical advances, including stem cell therapies, telomerase-based treatments, tissue engineering, genetherapy, and growing rejection-proof organs (Longo et al 2015;Kennedy and Pennypacker 2015;Moskalev and Pasyukova 2014). Thus, it is important to consider the implications of greatly extended healthy life expectancies (de Grey et al, 2002;Hall, 2006, 2010).…”

Section: Introductionmentioning

confidence: 96%

Opportunities and challenges of a world with negligible senescence

Hughes

Kuhn

Margolese-Malin

et al. 2015

Technological Forecasting and Social Change

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a b s t r a c tThe development of anti-aging technologies could have dramatic implications for a world already challenged by population aging. We explore how the world might evolve given the development and deployment of technologies capable of nearly eliminating mortality and morbidity from most causes. We consider both the great benefits and some of the complex sociopolitical rebalancing resulting from such advances. We use the International Futures (IFs) long-term, multi-issue, global forecasting system in our analysis of the interactions among demographic changes, the related changes in health costs and government finances, shifts in labor force participation, resultant economic transformations, and the environmental sustainability of the dramatically-altered human demands that emerge. We find that the widespread deployment of anti-senescence technologies would cause populations to surge-making fertility rates an issue of tremendous social import-while a much larger, healthier, labor force would spur economic growth. But this is not a given; the cost of treating entire adult populations could prove unbearable to non-high-income economies without significant transfers within and across societies. In the absence of new transformative production technologies, life-pattern financing would require the virtual elimination of retirement and a major restructuring of government finances. Pressures on the environment would also greatly intensify.

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Section: Introductionmentioning

confidence: 96%

Opportunities and challenges of a world with negligible senescence

Hughes

Kuhn

Margolese-Malin

et al. 2015

Technological Forecasting and Social Change

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“…Increasing human life expectancy is one of the most important aims of modern preventive medicine 1,2,3 . Currently, there are more than 20 substances, known as geroprotectors, which demonstrate the ability to increase the lifespan of animals 4,5,6 . Based on the free-radical theory of aging, antioxidants are also considered to be geroprotectors 7,8 .…”

Section: Introductionmentioning

confidence: 99%

Hepato- and Nephroprotective Effects of the Polyphenol Concentrate From Cabernet Sauvignon Grape Varieties Cultivated in Kazakhstan in the Experimental Model Of CCL4-Induced Toxicity

Nurgozhin

Sergazy

Adilgozhina

et al. 2017

IJTPR

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Objective:This study investigates the hepatoprotective effect and the antioxidant role of polyphenol concentrate in the experimental model of carbon tetrachloride (CCl4) induced toxicity. Methods: Antioxidant activity of Cabernet Sauvignon grape polyphenol were evaluated by radical scavenging of 1,1-diphenyl-2-picryl hydrazyl radical (DPPH), 2,2’-azinobis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS.+). In addition, the effects of polyphenol concentrate on the survival of Wistar rats in the toxicity model, was also investigated. The polyphenol concentrate was administered for 5 five days prior to injection of carbon tetrachloride in a sub-lethal dose of 300 mg/kg of animal body weight in order to perform histological examinations of the liver and kidney, and detect the levels of AST, ALT and bilirubin. Results: Administration of polyphenol concentrate increased animal survival in the experimental model. Moreover, the intragastric administration of polyphenol concentrate prior to the initiation of the experimental model of toxicity, which was caused by a sub-lethal CCl4 dose, reduced morphological injuries in the liver and kidney, decreased the AST and ALT levels of the blood serum. Discussion and conclusion: Our data demonstrate that polyphenol concentrate possesses an antioxidant potential both in vitro and in vivo by reducing antioxidant stress that was caused by CCl4 administration into rats.

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“…It is noted that the heritability of age at time of death was estimated at about 25% and it seems clear that epigenetic modifications (influence of environment on the genome) have a key role, as individuals with a genetic background similar (eg. homozygous twins) can age very differently according to the environment where they live [29,30].…”

Section: Genetic Mechanismsmentioning

confidence: 99%

Theories of Human Aging of Molecules to Society

Cabrera¹

2015

MOJI

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Aging is a process of deterioration of physiological functions, time-dependent, leading to homeoestenosis. The causes and mechanisms of this process are not yet fully clarified so have issued numerous theories to explain it.The article reviews the major theories of human aging, while proposing a classification that covers the fundamental mechanisms, including deregulation of the immune response (oxy-inflamm-aging) as one of the most cited today.The theories also include those relating to the psychosocial aspects of aging, taking a holistic approach to this biological process of humans.

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From theories of aging to anti-aging interventions

Cited by 11 publications

References 20 publications

Opportunities and challenges of a world with negligible senescence

Opportunities and challenges of a world with negligible senescence

Hepato- and Nephroprotective Effects of the Polyphenol Concentrate From Cabernet Sauvignon Grape Varieties Cultivated in Kazakhstan in the Experimental Model Of CCL4-Induced Toxicity

Theories of Human Aging of Molecules to Society

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