Front Cover: An Iodide‐Mediated Anodic Amide Coupling (Chem. Eur. J. 54/2022)

Großmann, Luca Marius; Beier, Vera; Duttenhofer, Lea; Lennartz, Laura; Opatz, Till

doi:10.1002/chem.202202724

Cited by 2 publications

(2 citation statements)

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“…[6,66] In this context, it is worth mentioning the pioneering work of Ke et al, [67] who utilized TBAB as the electrolyte to obtain a broad range of amides. Subsequently, Opatz and coworkers [68] made slight modifications, successfully synthesizing more functionalized amides and dipeptides (Figure 13).…”

Section: Electrochemical Approachesmentioning

confidence: 99%

Contemporary Approaches for Amide Bond Formation

Acosta‐Guzmán,

Ojeda‐Porras,

Gamba‐Sánchez

2023

Adv Synth Catal

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Amide bond construction has garnered significant interest in recent decades due to amides being one of the most prevalent functional groups among bioactive molecules. Out of the thirty‐seven new drugs approved by the FDA in 2022, eleven are small molecules containing at least one amide bond. Additionally, there are nineteen large molecules approved as new drugs, some of which have peptide structures, and therefore, also bear amide bonds. In recent years, multiple teams have embraced the challenge of developing more efficient methods for amide bond formation. This dedication has led to numerous publications appearing monthly in prestigious journals, showcasing significant advancements in this field. The primary goal of this review is to present the most viable strategies for constructing the amide bond. It is crucial to differentiate between amide bond formation and amide synthesis; hence, the focus is on describing specific methods for forming new C(O)−N bonds. In particular, this review concentrates on the methods developed within the last six years. There is a particular emphasis on new approaches that consider the thought process when selecting the starting materials and functional groups. This approach ensures coverage of all the most common chemical transformations that yield new amide bonds.

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Section: Electrochemical Approachesmentioning

confidence: 99%

Contemporary Approaches for Amide Bond Formation

Acosta‐Guzmán,

Ojeda‐Porras,

Gamba‐Sánchez

2023

Adv Synth Catal

View full text Add to dashboard Cite

show abstract

“…8,9 Over the last few decades, numerous stoichiometric coupling agents have emerged for carboxylic acid activation. [10][11][12][13] These methods have proven effective for various amides; however, the reagents tend to be toxic and hard to separate, unrecoverable waste is produced and these methods fall short in terms of adhering to the principles of green chemistry. Lately, various nonclassical strategies have been developed, such as amidation of aldehydes, 14,15 amino carbonylation of alkynes, 16 and oxidation of alcohols with amines.…”

Section: Introductionmentioning

confidence: 99%