Front pattern of invasion in squamous cell carcinoma of the penis: New prognostic factor for predicting risk of lymph node metastases

Guimarães, Gustavo Cardoso; Lopes, Ademar; Campos, Rodrigo Sousa Madeira; Zéqui, Stênio de Cássio; Leal, Marcos Lima de Oliveira; Carvalho, André Lopes; Cunha, Isabela Werneck da; Soares, Fernando Augusto

doi:10.1016/j.urology.2006.01.050

Cited by 55 publications

(31 citation statements)

References 28 publications

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“…tipos de cánceres 6,11,19,22,23 . Junto con ellos, indicadores clínicos, como el sitio de ubicación de la lesión primaria y la edad del paciente son importantes para evaluar el pronóstico de sobrevida de los enfermos de CCECO.…”

Section: Discussionunclassified

Rol de las características clínicas e histológicas como factores pronósticos para la sobrevida en pacientes con carcinoma de células escamosas de la cavidad oral

et al. 2010

Rev Chil Cir

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Rol de las características clínicas e histológicas como factores pronósticos para la sobrevida en pacientes con carcinoma de células escamosas de la cavidad oral* Background: Survival of patients with oral squamous cell carcinoma is low and depends mostly on TNM staging of the tumor. Aim: To perform a retrospective analysis of a series of patients with oral squamous cell carcinoma. Material and Methods: Retrospective review of patients with the diagnosis, seen between 1995 and 2006 in a regional hospital. Host infl ammatory response and pattern of tumor invasion were assessed using the staging proposed by Bryne et al. Results: The medical records of 36 patients aged 39 to 89 years, were reviewed. During the study period, 15 patients died. Better survival was associated to a low pattern of tumor invasion and a high infl ammatory response and the topographic location of the tumor. Conclusions: Infl ammatory response, tumor invasion and location are associated with survival in oral squamous cell carcinoma.Key words: Oral cancer, squamous cell, survival. ResumenIntroducción: El carcinoma de células escamosas de la cavidad oral (CCECO) es una patología cuyo comportamiento es producto de interrelaciones con el huésped, esto es, por el patrón de invasión (PI) histopatológica y la respuesta infl amatoria (RI). El objetivo de este estudio es analizar las características clínicas e histopatológicas como factores pronóstico, en términos de supervivencia (SV) en pacientes con CCECO. Material y Método: Serie de casos. Se incluyeron pacientes diagnosticados en el Hospital Regional de Talca y Hospital Base de Curicó entre los años 1995 y 2006. Se revisaron las fi chas clínicas y biopsias de 36 pacientes con CCECO. Se determinó el Frente Invasivo Tumoral (FIT), evaluándose los parámetros propuestos por el sistema de graduación de Bryne (PI y RI) y factores de importancia clínica como localización topográfi ca de la lesión, edad y género, relacionándolos con SV mediante curvas de Kaplan-Meier y Log Rank test. Posteriormente, se aplicó una regresión de Cox para obtener un análisis multivariado y cálculo de RR. Del total de Rev.

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Section: Discussionunclassified

Rol de las características clínicas e histológicas como factores pronósticos para la sobrevida en pacientes con carcinoma de células escamosas de la cavidad oral

et al. 2010

Rev Chil Cir

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“…[38][39][40][41][42] Recent work has suggested that lymphatic invasion and an infiltrating (rather than pushing) pattern of tumour invasion are also independent prognostic factors in the development of nodal metastases. 10,43 These studies have been used to stratify patients into low-risk, intermediate-risk and high-risk groups based on their primary disease pathology. 38,44 Solsona and colleagues 38 found lowrisk patients to be those with Ta, Tis or grade 1 disease, associated with less than a 17% of nodal micrometastases.…”

Section: Risk Stratification In Penile Cancermentioning

confidence: 99%

“…4,7,8 Recent series have demonstrated rates of clinical node positivity at presentation between 22% and 61%. 5,9,10 Lymphadenopathy in patients with clinically palpable nodal disease should be reconciled between reactive adenopathy and true metastatic disease, as infection of this cutaneous neoplasm can also enlarge nodes in the groin. False-positive rates for palpable adenopathy can exceed 50%.…”

mentioning

confidence: 99%

What next? Managing lymph nodes in men with penile cancer

Leveridge

Morash

2013

CUAJ

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The management of patients with squamous cell carcinoma of the penis is often daunting given its rarity and subsequent lack of high-level evidence to support our decision-making. This culminates in the complex surgical issues involving the management of the regional lymph nodes, which is of critical importance to both quantity and quality of life for these patients. This review aims to highlight the decisive issues surrounding the management of the pelvic and inguinal lymph nodes in the setting of squamous cell carcinoma of the penis, and to spotlight recently published information that adds credence to accepted management strategies of both the clinically positive and negative groin after successful management of the primary lesion.

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“…22 Among the different histologies, sarcomatoid variants have the worst prognosis, with an 89% risk of lymph node invasion. 23 The main components in a pathology report should include: anatomic site, tumour size, histologic type, 24 grade, 25 growth pattern, 26 invasive front, 27 depth of invasion, tumour thickness, resection margins, lymphovascular invasion, and perineural invasion. 28 These components play a critical role in determining both prognosis and treatment.…”

Section: Management Of Carcinoma Of the Penismentioning

confidence: 99%

Management of carcinoma of the penis: Consensus statement from the Canadian Association of Genitourinary Medical Oncologists (CAGMO)

Richter

Ruether

Wood

et al. 2013

CUAJ

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Front pattern of invasion in squamous cell carcinoma of the penis: New prognostic factor for predicting risk of lymph node metastases

Cited by 55 publications

References 28 publications

Rol de las características clínicas e histológicas como factores pronósticos para la sobrevida en pacientes con carcinoma de células escamosas de la cavidad oral

Rol de las características clínicas e histológicas como factores pronósticos para la sobrevida en pacientes con carcinoma de células escamosas de la cavidad oral

What next? Managing lymph nodes in men with penile cancer

Management of carcinoma of the penis: Consensus statement from the Canadian Association of Genitourinary Medical Oncologists (CAGMO)

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