Frontal Assessment Battery and Differential Diagnosis of Frontotemporal Dementia and Alzheimer Disease

Slachevsky, Andrea; Villalpando, Juan Manuel; Sarazin, Marie; Hahn-Barma, Valérie; Pillon, B.; Dubois, Bruno

doi:10.1001/archneur.61.7.1104

Cited by 261 publications

(195 citation statements)

References 22 publications

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“…The FAB provides a useful screening instrument for executive dysfunction as shown in several clinical investigations, including studies on Parkinson's disease, Alzheimer's disease, or stroke 20, 43, 44. Brain imaging studies revealed positive correlations of decreased FAB scores indicating executive dysfunction and reductions of brain tissue perfusion located to the left middle frontal gyrus and the right superior frontal gyrus in patients with MCI, Alzheimer's disease, and frontotemporal lobe dementias 45, 46, 47.…”

Section: Discussionmentioning

confidence: 99%

Longitudinal profile of iron accumulation in good‐grade subarachnoid hemorrhage

Scherfler

Schiefecker

Delazer

et al. 2016

Ann Clin Transl Neurol

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Objective MRI parameters of iron concentration (R2*, transverse relaxation rate), microstructural integrity (mean diffusivity and fractional anisotropy), as well as gray and white matter volumes were analyzed in patients with subarachnoid hemorrhage (SAH) and uncomplicated clinical course to detect the evolution of brain tissue changes 3 weeks and 12 months after ictus.Methods MRI scans of 14 SAH patients (aneurysm of the anterior communicating artery, n = 5; no aneurysm n = 9) were compared with 14 age‐matched healthy control subjects. Statistical parametric mapping (SPM) was applied to objectively identify focal changes of MRI parameters throughout the entire brain and to correlate image parameters with neuropsychological measures.Results SPM localized significant bilateral increases in R2* signal within the white matter compartment of the temporal and parietal lobe and the cingulate gyrus (P < 0.001) which did not change significantly at 12 months. Significant gray matter volume reduction of the left insula and superior temporal gyrus (P < 0.001), as well as decreases in fractional anisotropy of the cingulate gyrus (P < 0.01) were also evident at 12 months. Significant correlations were found between fractional anisotropy signal alterations adjacent to the left middle and superior frontal gyrus and cognitive parameters of executive dysfunction (P < 0.001).InterpretationThe study indicates that iron is trapped predominantly throughout large portions of the white matter compartment in SAH patients at 12 months postbleeding. Increased disintegration of fiber tracts colocalizing with iron overload and correlating with lower executive function performance suggests that the white matter compartment is primarily susceptible toward long‐term damage in patients with good clinical grade SAH.

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Section: Discussionmentioning

confidence: 99%

Longitudinal profile of iron accumulation in good‐grade subarachnoid hemorrhage

Scherfler

Schiefecker

Delazer

et al. 2016

Ann Clin Transl Neurol

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show abstract

“…Results are unclear with regard to the Comprehension subtest (Butters, Goldstein, Allen & Shemansky, 1998;Peavy et al, 2001;Randolph et al, 1993). Since the Similarities subtest requires both memory functions and executive processing (Dobbins & Russell, 1990;Insingrini & Vazou, 1997;Slachevsky et al, 2004), it is not likely that the VaD and AD patients can be distinguished on this task. Also, the Arithmetic test might be more impaired in AD patients (Hirono et al, 1998), but arithmetic functions equally require frontal related processes (Dehaene, Molko, Cohen & Wilson, 2004;Rivera, Menon, White, Glaser & Reiss, 2002), such as working memory.…”

Section: Methodsmentioning

confidence: 99%

Distinguishing between Vascular Dementia and Alzheimer's Disease by Means of the WAIS: A Meta-analysis

Oosterman

Scherder

2006

Journal of Clinical and Experimental Neuropsychology

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“…It consists of six subtests assessing conceptualization, cognitive fl exibility, motor programming, sensitivity to interference, motor inhibitory control, and prehension behavior. The authors of the FAB have proposed this test for the evaluation of different kinds of frontal dysfunction, and also to distinguish between neurological pathologies such bvFTD and AD (Slachevsky et al, 2004 ). They report correlations with executive measures such as the Wisconsin Card Sorting Test (WCST) and measures of general cognitive functioning (Mattis Dementia Scale), while highlighting the lack of correlation with the Mini Mental State Examination (MMSE).…”

Section: Introductionmentioning

confidence: 99%