Frontal cortex cooling and modulation of brain frequencies using a wearable Peltier device

Mujib, Muhammad Danish; Rao, Ahmad Zahid; Hasan, Muhammad Abul; Ikhlaq, Ayesha; Buzdar, Saeed Ahmad; Qazi, Saad Ahmed

doi:10.1016/j.physb.2023.414641

Cited by 7 publications

(5 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The significant effect of neuromodulation on pain tolerance, pain inhibition and cognitive test (Stroop test score) was evaluated using Paired wise t-test for different stimulation types (anodal-tDCS, Cathodal-tDCS, TENS and Control) and stimulation condition (Pre-Stage and Post-Stage). The t-values were calculated by using (5) for Pre-Stage, Post-Stage and neuromodulation conditions All results are expressed and stated as the mean ± standard error of the mean, and p ˂0.05 was set as significance level.…”

Section: Discussionmentioning

confidence: 99%

“…AIN, a multisystem disorder that influences psychological and neurological processes resulting in discomfort by evoking a maladaptive behavior reinforced by inadequate treatment and misuse of medication [1]. Pain due to activation of afferent nerve fibers in response to noxious thermal, chemical, or mechanical stimuli with potential to cause threatening damage to non-neural tissue is characterized as Nociceptive pain [2,3] and can be induced by multiple approaches some of which includes Peltier device, Cold Pressor Test and pin prick [4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Comparative Neurological and Behavioral Assessment of Central and Peripheral Stimulation Technologies for Induced Pain and Cognitive Tasks

Mujib,

Rao,

Hasan

et al. 2024

Preprint

View full text Add to dashboard Cite

Pain is a multifaceted multisystem disorder that adversely affects neuro-psychological processes. This study compares the effectiveness of central-stimulation (tDCS) and peripheral-stimulation (TENS) in pain-inhibition during a cognitive-task in healthy volunteers and to observe potential neuro-cognitive improvements. Healthy eighty volunteers went through a complete experimental protocol comprising pain-induction (CPT), administration of tDCS/TENS, EEG-data acquisition, and cognitive assessments. The protocol for this study is categorized into 04-groups: G1(Control), G2(TENS), G3(Anodal-tDCS), and G4(Cathodal-tDCS). Paired t-tests (p

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comparative Neurological and Behavioral Assessment of Central and Peripheral Stimulation Technologies for Induced Pain and Cognitive Tasks

Mujib,

Rao,

Hasan

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…This streamlined approach would offer greater feasibility for implementation in clinical settings, potentially reducing the need for multiple visits and thereby lowering training and logistical costs. Future studies could also consider incorporating haptic feedback to investigate the impact of tactile sensations [36], thermal sensations [37], and physical activity [38]. While it was beyond the scope of this study, a more comprehensive analysis could elucidate the broader impact of surface EEG-based NF sessions on other deep and adjacent structures such as areas 8, 9, and 39 [39,40].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of audiovisual neurofeedback training for attention enhancement: a multimodal approach

Ather,

Ejaz,

Rao

et al. 2024

NeuroReport

Self Cite

View full text Add to dashboard Cite

Attention is a cognitive process that involves focusing mental resources on specific stimuli and plays a fundamental role in perception, learning, memory, and decision-making. Neurofeedback (NF) is a useful technique for improving attention, providing real-time feedback on brain activity in the form of visual or auditory cues, and allowing users to learn to self-regulate their cognitive processes. This study compares the effectiveness of different cues in NF training for attention enhancement through a multimodal approach. We conducted neurological (Quantitative Electroencephalography), neuropsychological (Mindfulness Attention Awareness Scale-15), and behavioral (Stroop test) assessments before and after NF training on 36 healthy participants, divided into audiovisual (G1) and visual (G2) groups. Twelve NF training sessions were conducted on alternate days, each consisting of five subsessions, with pre- and post-NF baseline electroencephalographic evaluations using power spectral density. The pre-NF baseline was used for thresholding the NF session using the beta frequency band power. Two-way analysis of variance revealed a significant long-term effect of group (G1/G2) and state (before/after NF) on the behavioral and neuropsychological assessments, with G1 showing significantly higher Mindfulness Attention Awareness Scale-15 scores, higher Stroop scores, and lower Stroop reaction times for interaction effects. Moreover, unpaired t-tests to compare voxel-wise standardized low-resolution brain electromagnetic tomography images revealed higher activity of G1 in Brodmann area 40 due to NF training. Neurological assessments show that G1 had better improvement in immediate, short-, and long-term attention. The findings of this study offer a guide for the development of NF training protocols aimed at enhancing attention effectively.

show abstract

“…Pain is a multisystem disorder that influences psychological and neurological processes resulting in discomfort by evoking a maladaptive behavior reinforced by inadequate treatment and misuse of medication [ 1 ]. Pain due to activation of afferent nerve fibers in response to noxious thermal, chemical, or mechanical stimuli with potential to cause threatening damage to non-neural tissue is characterized as nociceptive pain [ 2 , 3 ] and can be induced by multiple approaches, some of which include the Peltier device, the Cold Pressor Test, and the pin-prick test [ 4 , 5 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Comparative Neurological and Behavioral Assessment of Central and Peripheral Stimulation Technologies for Induced Pain and Cognitive Tasks

Mujib,

Rao,

Hasan

et al. 2024

Biomedicines

Self Cite

View full text Add to dashboard Cite

Pain is a multifaceted, multisystem disorder that adversely affects neuro-psychological processes. This study compares the effectiveness of central stimulation (transcranial direct current stimulation—tDCS over F3/F4) and peripheral stimulation (transcutaneous electrical nerve stimulation—TENS over the median nerve) in pain inhibition during a cognitive task in healthy volunteers and to observe potential neuro-cognitive improvements. Eighty healthy participants underwent a comprehensive experimental protocol, including cognitive assessments, the Cold Pressor Test (CPT) for pain induction, and tDCS/TENS administration. EEG recordings were conducted pre- and post-intervention across all conditions. The protocol for this study was categorized into four groups: G1 (control), G2 (TENS), G3 (anodal-tDCS), and G4 (cathodal-tDCS). Paired t-tests (p < 0.05) were conducted to compare Pre-Stage, Post-Stage, and neuromodulation conditions, with t-values providing insights into effect magnitudes. The result showed a reduction in pain intensity with TENS (p = 0.002, t-value = −5.34) and cathodal-tDCS (p = 0.023, t-value = −5.08) and increased pain tolerance with TENS (p = 0.009, t-value = 4.98) and cathodal-tDCS (p = 0.001, t-value = 5.78). Anodal-tDCS (p = 0.041, t-value = 4.86) improved cognitive performance. The EEG analysis revealed distinct neural oscillatory patterns across the groups. Specifically, G2 and G4 showed delta-power reductions, while G3 observed an increase. Moreover, G2 exhibited increased theta-power in the occipital region during CPT and Post-Stages. In the alpha-band, G2, G3, and G4 had reductions Post-Stage, while G1 and G3 increased. Additionally, beta-power increased in the frontal region for G2 and G3, contrasting with a reduction in G4. Furthermore, gamma-power globally increased during CPT1, with G1, G2, and G3 showing reductions Post-Stage, while G4 displayed a global decrease. The findings confirm the efficacy of TENS and tDCS as possible non-drug therapeutic alternatives for cognition with alleviation from pain.

show abstract

Frontal cortex cooling and modulation of brain frequencies using a wearable Peltier device

Cited by 7 publications

References 53 publications

Comparative Neurological and Behavioral Assessment of Central and Peripheral Stimulation Technologies for Induced Pain and Cognitive Tasks

Comparative Neurological and Behavioral Assessment of Central and Peripheral Stimulation Technologies for Induced Pain and Cognitive Tasks

Efficacy of audiovisual neurofeedback training for attention enhancement: a multimodal approach

Comparative Neurological and Behavioral Assessment of Central and Peripheral Stimulation Technologies for Induced Pain and Cognitive Tasks

Contact Info

Product

Resources

About