Frontal lobe dysfunction in essential tremor

Gasparini, Marina; Bonifati, Vincenzo; Fabrizio, Edito; Fabbrini, Giovanni; Brusa, Livia; Lenzi, Gian Luigi; Meco, Giuseppe

doi:10.1007/s004150170181

Cited by 174 publications

(179 citation statements)

References 18 publications

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“…Cognitive impairments related to impairments in the frontal-cerebellar circuit appear to be the most prominent feature of ET. 4 Despite the high prevalence of ET and the impact of cognitive impairments on quality of life, the spectrum and neural basis of these impairments are not fully characterized. Although a number of DTI studies have been conducted to better understand ET pathology, none have focused on the cognitive correlates of the disease.…”

Section: Discussionmentioning

confidence: 99%

“…Various studies have shown cognitive impairment, especially executive-visuospatial dysfunction and attention deficits, in patients with ET. 3,4 Voxel-based morphometry studies in ET have found volume reductions in the cerebellum and cerebrum (frontal lobe, insula, and cingulum). 5,6 While voxel-based morphometry analysis is useful for demonstrating regional GM changes, DTI provides information about the microstructural organization of WM.…”

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confidence: 99%

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White Matter Correlates of Cognitive Impairment in Essential Tremor

Bhalsing¹,

Kumar

Saini

et al. 2014

AJNR Am J Neuroradiol

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

White Matter Correlates of Cognitive Impairment in Essential Tremor

Bhalsing¹,

Kumar

Saini

et al. 2014

AJNR Am J Neuroradiol

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“…Patients also may have signs of more widespread cerebellar involvement (e.g., intention tremor, ataxia; Deuschl et al 2000;Singer et al 1994;Stolze et al 2000), abnormalities referable to the basal ganglia (e.g., rest tremor, subclinical signs of bradykinesia; Cohen et al 2003;Rajput et al 1993), and cognitive deficits (Gasparini et al 2001;Lombardi et al 2001). ET is considered to be distinct from age-related enhanced physiologic tremor, which has different clinical and electrophysiologic features (Louis et al 1997;Louis and Pullman 2001).…”

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confidence: 99%

Association between essential tremor and blood lead concentration.

Louis

Jurewicz

Applegate

et al. 2003

Environ Health Perspect

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Lead is a ubiquitous toxicant that causes tremor and cerebellar damage. Essential tremor (ET) is a highly prevalent neurologic disease associated with cerebellar involvement. Although environmental toxicants may play a role in ET etiology and their identification is a critical step in disease prevention, these toxicants have received little attention. Our objective was to test the hypothesis that ET is associated with lead exposure. Therefore, blood lead (BPb) concentrations were measured and a lifetime occupational history was assessed in ET patients and in controls. We frequency matched 100 ET patients and 143 controls on age, sex, and ethnicity. BPb concentrations were analyzed using graphite furnace atomic absorption spectrophotometry. A lifetime occupational history was reviewed by an industrial hygienist. BPb concentrations were higher in ET patients than in controls (mean +/- SD, 3.3 +/- 2.4 and 2.6 +/- 1.6 microg/dL, respectively; median, 2.7 and 2.3 microg/dL; p = 0.038). In a logistic regression model, BPb concentration was associated with diagnosis [control vs. ET patient, odds ratio (OR) per unit increase = 1.21; 95% confidence interval (CI), 1.05-1.39; p = 0.007]. BPb concentration was associated with diagnosis (OR per unit increase = 1.19; 95% CI, 1.03-1.37; p = 0.02) after adjusting for potential confounders. Prevalence of lifetime occupational lead exposure was similar in ET patients and controls. We report an association between BPb concentration and ET. Determining whether this association is due to increased exposure to lead or a difference in lead kinetics in ET patients requires further investigation.

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“…Studies on this subject showed cognitive impairment with affected visuospatial abilities, verbal memory, executive functions, verbal fluency, naming and working memory in ET (12,33,34,35,36). Moreover, in a limited number of studies conducted with young patients, this condition has been proved to be present even at early stages (6,13).…”

Section: Discussionmentioning

confidence: 86%

“…In several studies, findings suggesting cerebral-thalamocortical tract dysfunction were found in patients with ET. Mild cognitive impairment characterized by impairment of visuospatial functions, verbal memory, and executive functions has been shown in young patients (8,9,10,11,12,13).…”

Section: Introductionmentioning

confidence: 99%

Cognitive Impairment in Young Multiple Sclerosis and Essential Tremor Patients: A Comparative Study

Şengül¹,

Şengül²,

Yücel³

et al. 2016

tnd

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Objective: In multiple sclerosis (MS); memory, attention, information processing speed, and executive function deficits associated with cortical demyelination and atrophy can be seen in the early phases. In essential tremor (ET) cognitive impairment associated with cerebral-thalamocortical pathway dysfunction, which is characterized by visuospatial functions, verbal memory, and executive functions were seen. We aimed to evaluate cognitive impairment in patients with MS and ET, and to compare the features of impairment. Materials and Methods:Thirty patients ET (mean age 27.7±6.8 years), 30 patients with MS (mean age 32.4±6.6 years) and 20 healthy controls (mean age 28.81±7.3 years) were recruited for the study. For assessing cognitive impairment, the Montreal Cognitive Assessment (MoCA) test was applied to all participants. For grading the disease, the Fahn-Tolosa-Marin Tremor Rating Scale was used in the ET group, and the Expanded Disability Status Scale was used in the MS group. Results:The total MoCA mean scores in patients with MS was 22.4±4.34, 25.8±2.7 in patients with ET, and 28.2±1.8 in controls. When we compared the patients with the controls, the patients' mean score was lower than in the controls. Cognitive impairment in patients with MS was more apparent than in patients with ET. Naming, attention, language, and delayed recall subgroups in patients with MS were more affected than in patients with ET. Conclusion:In this present study, we determined cognitive impairment can be seen in both group of patients, and MS can cause more prominent deficit than ET. In addition, our study confirms that cognitive impairment in MS and ET can be detected using the MoCA test. Keywords: Multiple sclerosis, essential tremor, cognitive impairment, Montreal Cognitive Assessment testAmaç: Multipl sklerozda (MS) kortikal demiyelinizasyon ve atrofi ile ilişkili bellek, dikkat, bilgi işleme hızı ve yönetici işlev bozuklukları hastalığın ilk dönemlerinden itibaren görülmektedir. Esansiyel tremorda (ET) ise serebello-talamo-kortikal yol disfonksiyonunu ile viziospasyal fonksiyonlar, verbal hafıza ve yine yürütücü işlevlerin bozulması ile karakterize kognitif etkilenmenin olduğu gösterilmiştir. Çalışmamızda MS ve ET hastalarında kognitif bozukluğunun değerlendirilmesini ve özellikleri açısından karşılaştırılmasını amaçladık. Gereç ve

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Frontal lobe dysfunction in essential tremor

Cited by 174 publications

References 18 publications

White Matter Correlates of Cognitive Impairment in Essential Tremor

White Matter Correlates of Cognitive Impairment in Essential Tremor

Association between essential tremor and blood lead concentration.

Cognitive Impairment in Young Multiple Sclerosis and Essential Tremor Patients: A Comparative Study

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