Frontal-Striatal Dysfunction During Planning in Obsessive-Compulsive Disorder

Heuvel, Odile A. van den; Veltman, Dick J.; Groenewegen, Henk J.; Cath, Daniëlle C.; Balkom, A.J.L.M. van; Hartskamp, Julie van; Barkhof, Frederik; Dyck, Richard van

doi:10.1001/archpsyc.62.3.301

Cited by 359 publications

(212 citation statements)

References 76 publications

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“…Consistently, several studies have suggested that checking behaviors may be specifically related to deficits affecting action processing such as action planning (e.g., van den Heuvel et al, 2005) and action monitoring (e.g., Hajcak & Simons, 2002). More specifically, it has been suggested that the involvement of action planning deficits in checking behaviors is related to a defective use of internal representations to guide the course of action, which may lead checkers to rely on external cues and to repeat an action until they get cues informing them that the action has been completely performed (Purcell, Maruff, Kyrios, & Pantelis, 1998).…”

Section: Introductionmentioning

confidence: 71%

Level of agency in sub-clinical checking

Belayachi

Linden

2009

Consciousness and Cognition

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a b s t r a c tThis study examined cognitive representations of routine action, through the assessment of level of agency, in individuals with sub-clinical checking. The level of agency stems from Action Identification Theory [Vallacher, R. R., Wegner, D. M. (1989). Levels of personal agency: Individual variation in action identification. Journal of Personality and Social Psychology 57, 660-671], which states that how actions are usually identified (based on instrumental aspects or purpose) reflects the predominant accessibility of internal representation (movements executed vs. goal pursued). Furthermore, this framework proposed that altered action regulation is related to low-level of agency (i.e., action identification at an instrumental level). In the current study, the main result indicated that checking symptoms were related to a low-level of agency, that is, individuals with sub-clinical checking identified habitual actions on the basis of instrumental aspects. This seems to indicate that checkers may act with a lack of goal representations. The results are discussed in terms of the role of low-level of agency in checking phenomena and related cognitive dysfunction.

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Section: Introductionmentioning

confidence: 71%

Level of agency in sub-clinical checking

Belayachi

Linden

2009

Consciousness and Cognition

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“…Clearly, more research is needed to understand the precise functional significance of these findings but the negative correlations with dorsal prefrontal-striatal and parietal regions could reflect deficient emotional regulation mechanisms in compulsive hoarding 48 and would also be consistent with difficulties in planning, 49 another important feature of this syndrome. 50 Interestingly, only nonhoarding patients activated regions of the basal ganglia during symptom provocation and the degree of provoked anxiety correlated inversely with activation in this region in the entire sample (n = 29).…”

Section: Discussionmentioning

confidence: 99%

To discard or not to discard: the neural basis of hoarding symptoms in obsessive-compulsive disorder

et al. 2008

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Preliminary neuroimaging studies suggest that patients with the 'compulsive hoarding syndrome' may be a neurobiologically distinct variant of obsessive-compulsive disorder (OCD) but further research is needed. A total of 29 OCD patients (13 with and 16 without prominent hoarding symptoms) and 21 healthy controls of both sexes participated in two functional magnetic resonance imaging experiments consisting of the provocation of hoarding-related and symptom-unrelated (aversive control) anxiety. In response to the hoarding-related (but not symptom-unrelated) anxiety provocation, OCD patients with prominent hoarding symptoms showed greater activation in bilateral anterior ventromedial prefrontal cortex (VMPFC) than patients without hoarding symptoms and healthy controls. In the entire patient group (n = 29), provoked anxiety was positively correlated with activation in a frontolimbic network that included the anterior VMPFC, medial temporal structures, thalamus and sensorimotor cortex. Negative correlations were observed in the left dorsal anterior cingulate gyrus, bilateral temporal cortex, bilateral dorsolateral/medial prefrontal regions, basal ganglia and parieto-occipital regions. These results were independent from the effects of age, sex, level of education, state anxiety, depression, comorbidity and use of medication. The findings are consistent with the animal and lesion literature and several landmark clinical features of compulsive hoarding, particularly decision-making difficulties. Whether the results are generalizable to hoarders who do not meet criteria for OCD remains to be investigated.

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“…Neuroimaging studies have consistently shown that this task causes robust activation of the bilateral dorsolateral prefrontal cortex, inferior parietal cortex, and the caudate nucleus in healthy populations [Boghi et al, 2006; Dagher et al, 1999; van den Heuvel et al, 2003]. Therefore, the ToL task is a well‐suited paradigm to probe CSTC and fronto‐parietal functioning in psychiatric and neurological disorders characterized by fronto‐striatal and fronto‐parietal failure, such as obsessive‐compulsive disorder [van den Heuvel et al, 2005] and related anxiety disorders [van den Heuvel et al, 2011], schizophrenia [Eisenberg and Berman, 2010], and PD [Owen, 2004; Williams‐Gray et al, 2007]. With our study we sought to expand upon previous findings by using cross‐sectional neuroimaging, combining task‐related activation, network connectivity, and performance over time.…”

Section: Introductionmentioning

confidence: 99%

Impaired planning in Parkinson's disease is reflected by reduced brain activation and connectivity

Trujillo

Gerrits

Vriend

et al. 2015

Human Brain Mapping

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ObjectiveParkinson's disease (PD) often entails impairments of executive functions, such as planning. Although widely held that these impairments arise from dopaminergic denervation of the striatum, not all executive functions are affected early on, and the underlying neural dynamics are not fully understood. In a combined longitudinal and cross‐sectional study, we investigated how planning deficits progress over time in the early stages of PD compared to matched healthy controls. We used functional magnetic resonance imaging (fMRI) to identify accompanying neural dynamics.MethodsSeventeen PD patients and 20 healthy controls performed a parametric Tower of London task at two time points separated by ∼3 years (baseline and follow‐up). We assessed task performance longitudinally in both groups; at follow‐up, a subset of participants (14 patients, 19 controls) performed a parallel version of the task during fMRI. We performed meta‐analyses to localize regions‐of‐interest (ROIs), that is, the bilateral dorsolateral prefrontal cortex (DLPFC), inferior parietal cortex, and caudate nucleus, and performed group‐by‐task analyses and within‐group regression analyses of planning‐related neural activation. We studied task‐related functional connectivity of seeds in the DLPFC and caudate nucleus.ResultsPD patients, compared with controls, showed impaired task performance at both time‐points, while both groups showed similar performance reductions from baseline to follow‐up. Compared to controls, patients showed lower planning‐related brain activation together with decreased functional connectivity.ConclusionThese findings support the notion that planning is affected early in the PD disease course, and that this impairment in planning is accompanied by decreases in both task‐related brain activity and connectivity. Hum Brain Mapp 36:3703–3715, 2015. © 2015 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc.

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Frontal-Striatal Dysfunction During Planning in Obsessive-Compulsive Disorder

Cited by 359 publications

References 76 publications

Level of agency in sub-clinical checking

Level of agency in sub-clinical checking

To discard or not to discard: the neural basis of hoarding symptoms in obsessive-compulsive disorder

Impaired planning in Parkinson's disease is reflected by reduced brain activation and connectivity

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