Fronto-parietal engagement in response inhibition is inversely scaled with attention-deficit/hyperactivity disorder symptom severity

Kolodny, Tamar; Mevorach, Carmel; Stern, Pnina; Biderman, Natalie; Ankaoua, Maya; Tsafrir, Shlomit; Shalev, Lilach

doi:10.1016/j.nicl.2019.102119

Cited by 16 publications

(19 citation statements)

References 87 publications

(112 reference statements)

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“…The behavioural data revealed the typical response inhibition deficits in AD(H)D, i.e. an increase in false alarms relative to healthy controls ( Kolodny et al, 2020 , Metin et al, 2012 , Pievsky and McGrath, 2018 ), and worse response inhibition performance in the ADHD group than the ADD group ( Bluschke et al, 2016b ). The analysis of source-level theta band activity showed that theta power was stronger during trials requiring response inhibition than in those requiring response execution.…”

Section: Discussionmentioning

confidence: 91%

The dynamics of theta-related pro-active control and response inhibition processes in AD(H)D

Adelhöfer

Bluschke

Roessner

et al. 2021

NeuroImage: Clinical

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Section: Discussionmentioning

confidence: 91%

The dynamics of theta-related pro-active control and response inhibition processes in AD(H)D

Adelhöfer

Bluschke

Roessner

et al. 2021

NeuroImage: Clinical

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“…Therefore, like older children and adults (Kolodny et al, 2020;Mehnert et al, 2013;van Belle et al, 2014), 10-month-old infants activate the right parietal cortex when inhibition is required. This finding is consistent with recent evidence that the prefrontal and parietal cortex work in conjunction during early EF development (Fiske & Holmboe, 2019).…”

Section: Discussionmentioning

confidence: 99%

The neural correlates of inhibitory control in 10-month-old infants: a functional near-infrared spectroscopy study

Fiske¹,

Klerk²,

Lui³

et al. 2021

Preprint

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Inhibitory control, a core executive function, emerges in infancy and develops rapidly across childhood. Methodological limitations have meant that studies investigating the neural correlates underlying inhibitory control in infancy are rare. Employing functional near-infrared spectroscopy alongside a novel touchscreen task that measures response inhibition, this study aimed to uncover the neural underpinnings of inhibitory control in 10-month-old infants (N = 135). We found that when inhibition is required, the right prefrontal and parietal cortices were more activated than when there is no inhibitory demand. Further, activation in right prefrontal areas was associated with individual differences in response inhibition performance. This demonstrates that inhibitory control in infants as young as 10 months of age is supported by similar brain areas as in older children and adults. With this study we have lowered the age-boundary for localising the neural substrates of response inhibition to the first year of life.

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“…Although no significant association was found for ADHD core symptoms, our mediation analysis found a significant indirect effect of RNF219 ‐ AS1 rs3908461 on ADHD total symptom through executive inhibition as the mediator. Previous studies have found that children with ADHD exhibited a range of executive deficits, especially the inhibition function 49 . Family‐based behavioral genetics studies conducted in either ADHD 50 or general population 35 have suggested that inhibitory function—as an important executive function refers to the ability to control decision‐making, behaviors, and emotional impulse—is significantly heritable; and it may be considered a valid endophenotype of ADHD.…”

Section: Discussionmentioning

confidence: 99%

A potential association of RNF219‐AS1 with ADHD: Evidence from categorical analysis of clinical phenotypes and from quantitative exploration of executive function and white matter microstructure endophenotypes

Chen

et al. 2021

CNS Neurosci Ther

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Aims Attention‐deficit/hyperactivity disorder (ADHD) is a neuropsychiatric disorder of substantial heritability, yet emerging evidence suggests that key risk variants might reside in the noncoding regions of the genome. Our study explored the association of lncRNAs (long noncoding RNAs) with ADHD as represented at three different phenotypic levels guided by the Research Domain Criteria (RDoC) framework: (i) ADHD caseness and symptom dimension, (ii) executive functions as functional endophenotype, and (iii) potential genetic influence on white matter architecture as brain structural endophenotype. Methods Genotype data of 107 tag single nucleotide polymorphisms (SNP) from 10 candidate lncRNAs were analyzed in 1040 children with ADHD and 630 controls of Chinese Han descent. Executive functions including inhibition and set‐shifting were assessed by STROOP and trail making tests, respectively. Imaging genetic analyses were performed in a subgroup of 33 children with ADHD and 55 controls using fractional anisotropy (FA). Results One SNP rs3908461 polymorphism in RNF219‐AS1 was found to be significantly associated with ADHD caseness: with C‐allele detected as the risk genotype in the allelic model (P = 8.607E‐05) and dominant genotypic model (P = 9.628E‐05). Nominal genotypic effects on inhibition (p = 0.020) and set‐shifting (p = 0.046) were detected. While no direct effect on ADHD core symptoms was detected, mediation analysis suggested that SNP rs3908461 potentially exerted an indirect effect through inhibition function [B = 0.21 (SE = 0.12), 95% CI = 0.02‐0.49]. Imaging genetic analyses detected significant associations between rs3908461 genotypes and FA values in corpus callosum, left superior longitudinal fasciculus, left posterior limb of internal capsule, left posterior thalamic radiate (include optic radiation), and the left anterior corona radiate (P FWE corrected < 0.05). Conclusion Our present study examined the potential roles of lncRNA in genetic etiological of ADHD and provided preliminary evidence in support of the potential RNF219‐AS1 involvement in the pathophysiology of ADHD in line with the RDoC framework.

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Fronto-parietal engagement in response inhibition is inversely scaled with attention-deficit/hyperactivity disorder symptom severity

Cited by 16 publications

References 87 publications

The dynamics of theta-related pro-active control and response inhibition processes in AD(H)D

The dynamics of theta-related pro-active control and response inhibition processes in AD(H)D

The neural correlates of inhibitory control in 10-month-old infants: a functional near-infrared spectroscopy study

A potential association of RNF219‐AS1 with ADHD: Evidence from categorical analysis of clinical phenotypes and from quantitative exploration of executive function and white matter microstructure endophenotypes

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