Fronto-thalamo-striatal gray and white matter volumes and anisotropy of their connections in bipolar spectrum illnesses

Haznedar, M. Mehmet; Roversi, Francesca; Pallanti, Stefano; Baldini-Rossi, Nicolo; Schnur, David B.; LiCalzi, Elizabeth M.; Tang, Cheuk Y.; Hof, Patrick R.; Hollander, Eric; Buchsbaum, Monte S.

doi:10.1016/j.biopsych.2005.01.002

Cited by 191 publications

(151 citation statements)

References 75 publications

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“…This methodological shortcoming might explain the rather contradictory findings of DTI studies in BP, reporting predominantly increased ADC or decreased FA in frontal WM [19][20][21] with one study reporting increased as well as decreased FA in different ROIs. 22 The present findings have to be interpreted in light of some limitations.…”

Section: Diffusion Tensor Tractography In Bipolar Patients J Houenou mentioning

confidence: 84%

“…[19][20][21][22] As the amount of FA has been shown to be an indirect measures of the directionality and coherence of fiber tracts, 23,24 DTI studies in BP suggest a loss of coherence in frontal WM bundles. However, these studies have investigated predefined and limited regions of interest (ROIs), representing only a part of a specific WM bundles and might thus be susceptible to overlook subtle differences between study groups.…”

Section: Introductionmentioning

confidence: 99%

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Increased white matter connectivity in euthymic bipolar patients: diffusion tensor tractography between the subgenual cingulate and the amygdalo-hippocampal complex

et al. 2007

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Bipolar disorder has been associated with anatomical as well as functional abnormalities in a brain network that mediates normal and impaired emotion regulation. Previous brain imaging studies have highlighted the subgenual cingulate (SC) and the amygdalo-hippocampal (AH) complex as core regions of this network. Thus we investigated white matter (WM) fiber tracts between the SC and the AH region, the uncinate fasciculus, as well as between two control regions (pons and cerebellum), using diffusion tensor imaging tractography in 16 euthymic bipolar patients (BP) and 16 sex-, age-and handedness-matched controls. Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) of the reconstructed fiber bundle and the number of virtual reconstructed fibers were compared between groups. The tractography results revealed a significantly increased number of reconstructed fibers between the left SC and left AH in BP as compared to healthy controls. FA and ADC of the reconstructed fiber tract did not differ significantly between the groups. Furthermore, no significant group differences were observed neither for reconstructed fiber tracts between the right SC and right AH nor between the control regions. The present results suggest an altered WM pathway between the left SC and AH region and thus extend previous findings of anatomical and functional modifications in these structures in BP.

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Section: Diffusion Tensor Tractography In Bipolar Patients J Houenou mentioning

confidence: 84%

Section: Introductionmentioning

confidence: 99%

Increased white matter connectivity in euthymic bipolar patients: diffusion tensor tractography between the subgenual cingulate and the amygdalo-hippocampal complex

et al. 2007

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“…Diffusion tensor imaging studies that allow measurement of the structural integrity of specific white matter tracts have reported reduced integrity of white matter tracts in bilateral OFC in adult BD. 131,132 Recent findings indicate abnormalities specifically in left OFC and bilateral dorsal PFC. Here, studies have reported a greater number of reconstructed white matter fibers between left subgenual ACG and amygdala 133 and decreased integrity of bilateral white matter tracts in dorsal prefrontal cortical regions 129,134 in adult BD.…”

Section: Adult Bipolar Disordermentioning

confidence: 99%

A neural model of voluntary and automatic emotion regulation: implications for understanding the pathophysiology and neurodevelopment of bipolar disorder

2008

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The ability to regulate emotions is an important part of adaptive functioning in society. Advances in cognitive and affective neuroscience and biological psychiatry have facilitated examination of neural systems that may be important for emotion regulation. In this critical review we first develop a neural model of emotion regulation that includes neural systems implicated in different voluntary and automatic emotion regulatory subprocesses. We then use this model as a theoretical framework to examine functional neural abnormalities in these neural systems that may predispose to the development of a major psychiatric disorder characterized by severe emotion dysregulation, bipolar disorder.

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“…68,69 Moreover, decreased FA has been observed in the frontal tract and corpus callosum in patients with bipolar disorder. 70,71 In general, abnormal white matter connections are common in patients with schizophrenia and aŠec-tive disorders. 67 There are small numbers of studies in thisˆeld using non-Gaussian DWI.…”

Section: Neuropsychiatric Diseasementioning

confidence: 99%

Visualizing Non-Gaussian Diffusion: Clinical Application of q-Space Imaging and Diffusional Kurtosis Imaging of the Brain and Spine

Hori

Fukunaga

Masutani

et al. 2012

MRMS

105

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Recently, non-Gaussian diŠusion-weighted imaging (DWI) techniques, including qspace imaging (QSI) and diŠusional kurtosis imaging (DKI), have emerged as advanced methods to evaluate tissue microstructure in vivo using water diŠusion. QSI and DKI have shown promising results in clinical applications, such as in the evaluation of brain tumors (e.g., grading gliomas), degenerative diseases (e.g., speciˆc diagnosis of Parkinson disease), demyelinating diseases (e.g., assessment of normal-appearing tissue of multiple sclerosis), and cerebrovascular diseases (e.g., assessment of the microstructural environment of fresh infarctions). Representative metrics in clinical use are the full width at half maximum, also known as the mean displacement of the probability density function curve, which is derived from QSI, and diŠusional kurtosis, which is derived from DKI. These new metrics may provide information on tissue structure in addition to that provided by conventional Gaussian DWI investigations that use the apparent diŠusion coe‹cient and fractional anisotropy, recognized indices for evaluating disease and normal development in the brain and spine. In some clinical situations, sensitivity for detecting pathological conditions is higher using QSI and DKI than conventional DWI and diŠusion tensor imaging (DTI) because DWI and DTI calculations are based on the assumption that water molecules follow a Gaussian distribution, whereas hindrance of the distribution of water molecules by complex and restricted structures in actual neural tissues produces distributions that are far from Gaussian. We review the technical aspects and clinical applications of QSI and DKI, focusing on clinical use and in vivo studies and highlighting diŠerences from conventional diŠusional metrics.

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Fronto-thalamo-striatal gray and white matter volumes and anisotropy of their connections in bipolar spectrum illnesses

Cited by 191 publications

References 75 publications

Increased white matter connectivity in euthymic bipolar patients: diffusion tensor tractography between the subgenual cingulate and the amygdalo-hippocampal complex

Increased white matter connectivity in euthymic bipolar patients: diffusion tensor tractography between the subgenual cingulate and the amygdalo-hippocampal complex

A neural model of voluntary and automatic emotion regulation: implications for understanding the pathophysiology and neurodevelopment of bipolar disorder

Visualizing Non-Gaussian Diffusion: Clinical Application of q-Space Imaging and Diffusional Kurtosis Imaging of the Brain and Spine

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