Frontotemporal dementia and Alzheimer disease: evaluation of cortical atrophy with automated hemispheric surface display generated with MR images.

Kitagaki, Hajime; Mori, Etsuro; Yamaji, Shigeru; Ishii, Kazunari; Hirono, Nobutsugu; Kobashi, Syoji; Hata, Yoshinobu

doi:10.1148/radiology.208.2.9680572

Cited by 96 publications

(51 citation statements)

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“…Although the adult brain shows a high degree of symmetry for prominent cortical gyri and sulci (Maudgil et al 1998;Dale et al 1999;Fischl et al 1999), variations in surface morphology and asymmetries of transmitter systems occur (Hutsler et al 1998;Kovacs et al 1998;Nopoulos et al 2000;Watkins et al 2001;Sowell et al 2002). Cortical morphology varies with age and with the pathological state of the patient (Kitagaki et al 1998;Symonds et al 1999;Resnick et al 2000;Narr et al 2001a,b;Tang et al 2001;Hardy and Selkoe 2002). Reductions in the volume of specific brain regions occur in certain diseases; they are particularly evident in Alzheimer's disease (Anderson and Hubbard 1981;Ulrich and Stahelin 1984;Najlerahim and Bowen 1988;Tanabe et al 1997;Salat et al 1999;Regeur 2000), alcoholism Kril 1985, 1986;Pfefferbaum et al 1997Pfefferbaum et al , 2001Hommer et al 2001) and alcoholic cerebellar degeneration (Ferrer et al 1984;Kril and Butterworth 1997) and may also occur in schizophrenia (Brown et al 1986;Nasrallah 1995;Lauriello et al 1997;Sullivan et al 1998;De Lisi 1999;Hulshoff-Pol et al 2002).…”

Section: Tissue Dissectionmentioning

confidence: 99%

Biochemical and molecular studies using human autopsy brain tissue

Hynd

Lewohl

Scott

et al. 2003

Journal of Neurochemistry

222

171

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The use of human brain tissue obtained at autopsy for neurochemical, pharmacological and physiological analyses is reviewed. RNA and protein samples have been found suitable for expression profiling by techniques that include RT-PCR, cDNA microarrays, western blotting, immunohistochemistry and proteomics. The rapid development of molecular biological techniques has increased the impetus for this work to be applied to studies of brain disease. It has been shown that most nucleic acids and proteins are reasonably stable postmortem. However, their abundance and integrity can exhibit marked intra-and intercase variability, making comparisons between case-groups difficult. Variability can reveal important functional and biochemical information. The correct interpretation of neurochemical data must take into account such factors as age, gender, ethnicity, medicative history, immediate ante-mortem status, agonal state and post-mortem and post-autopsy intervals. Here we consider issues associated with the sampling of DNA, RNA and proteins using human autopsy brain tissue in relation to various ante-and postmortem factors. We conclude that valid and practical measures of a variety of parameters may be made in human brain tissue, provided that specific factors are controlled.

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Section: Tissue Dissectionmentioning

confidence: 99%

Biochemical and molecular studies using human autopsy brain tissue

Hynd

Lewohl

Scott

et al. 2003

Journal of Neurochemistry

222

171

View full text Add to dashboard Cite

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“…57 Imaging Features. While atrophy in the anterior temporal and medial frontal lobes is characteristic of frontotemporal lobar degeneration (On-line Fig 4), 58 specific imaging findings can reflect underlying subtypes. Bilaterally symmetric or right frontal atrophy is seen in the behavioral subtype.…”

Section: 45mentioning

confidence: 99%

Distinguishing Neuroimaging Features in Patients Presenting with Visual Hallucinations

Winton-Brown¹,

Ting

Mocellin³

et al. 2016

American Journal of Neuroradiology

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SUMMARY:Visual hallucinations are relatively uncommon presentations in medical and psychiatric clinics, where they are generally regarded as a marker of possible underlying "organic" brain disease. Thus, patients with visual hallucinations are often referred for imaging of the brain. This article presents a pragmatic approach for the radiologist reviewing such imaging. Because conditions that can present with visual hallucinations are legion, a familiarity with the features of the hallucinations themselves, which can serve as clues to the underlying cause, can be helpful in interpreting such cases. We consider the nature of visual hallucinations and the mechanisms underlying their formation. We then provide a framework to guide the search for their cause, first in terms of focal lesions along the visual pathway and then global conditions affecting Ͼ1 region. ABBREVIATIONS:CJD ϭ Creutzfeldt-Jakob disease; VH ϭ visual hallucination

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“…The segmented region helps physicians to diagnose various diseases such as volumetric and shape abnormality. For example, Alzheimer's disease diagnosis system was developed on three-dimensional MR brain image segmentation procedure [6], [7]. Image registration is the process of determining correspondence between all points in two images of the same scene.…”

Section: Medical Image Processingmentioning

confidence: 99%

“…First, we briefly describe medical image processing studies [6]- [10]. Second, we describe computational techniques based on fuzzy logic of three ultrasonic surgery support systems.…”

Section: Introductionmentioning

confidence: 99%

A Survey of Intelligent Computing in Medical and Health Care System

Hata

Nakajima

2014

IEICE Trans. Inf. & Syst.

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SUMMARYThis paper gives a survey of intelligent computational techniques in medical and health care system. First, we briefly describe diagnosable techniques in medical image processing. Next, we demonstrate two ultrasonic surgery support systems for orthopedic and rectum cancer surgeons. In them, intelligent computational technique plays a primary role. Third, computational techniques are introduced in human health care system. Usually, this goal is not to apply clinical treatment but to home use to pay consciousness to health. In it, a simple ECG and respiration meter are introduced with a mat sheet which detects heart rate and respiration. Finally, a medical big data application is introduced, that is, body weight prediction is shown based on autoregressive model. Thus, we show that intelligent computing is effective and essential in modern medical and health care system.

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Frontotemporal dementia and Alzheimer disease: evaluation of cortical atrophy with automated hemispheric surface display generated with MR images.

Cited by 96 publications

References 0 publications

Biochemical and molecular studies using human autopsy brain tissue

Biochemical and molecular studies using human autopsy brain tissue

Distinguishing Neuroimaging Features in Patients Presenting with Visual Hallucinations

A Survey of Intelligent Computing in Medical and Health Care System

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