Fructose 1–6 diphosphate prevents intestinal ischemic reperfusion injury and death in rats

Fructose-1,6-bisphosphate inhibits the expression of inducible nitric oxide synthase caused by oxygen-glucose deprivation through the inhibition of glutamate release in rat forebrain slices

“…Decreasing glutamate release by FBP would therefore inhibit iNOS expression. In addition, the oxidative stress produced in this situation might itself trigger the induction of iNOS (Melillo et al 1995) and it has been shown that FBP inhibits oxidant production (Sun et al 1990). We have recently demonstrated that activation of N-methyl-D-aspartate (NMDA) receptors by glutamate released after an ischaemic insult is involved in the expression of iNOS in rat forebrain slices via Ca 2+ -dependent activation of the transcription factor NF-kB (Cárdenas et al 2000).…”

Enhancement of Hypothermic Heart Preservation with Fructose 1,6-Diphosphate

“…FDP's many beneficial effects during ischemia and reperfusion include augmentation of carbohydrate utilization during ischemia [26], prevention of ischemia/reperfusion-induced leukocyte adherence [1], reduction of lipid peroxidation and oxygen free radical production [36], stimulation of nitric oxide synthase [27], improvement of hemorheological properties of red blood cells [5], chelation of extracellular calcium [22], stabilization of the plasma membrane [16], and prevention of platelet activation [7]. Among all the beneficial effects, its augmentation of glycolytic energy production has been the most elusive and potentially significant.…”

Fructose 1,6-Diphosphate Alleviates UV-Induced Oxidative Skin Damage in Hairless Mice

“…[8][9][10][11] Recent studies have suggested that FDP has a protective role in UVB-injured keratinocytes by attenuating PGE 2 production and COX-2 expression.…”

“…[8][9][10] In addition, it has been demonstrated that FDP significantly inhibits generation of oxygen free radicals by stimulated neutrophils 11) and mitigates the adverse effects of endotoxins by regulating the generation of nitric oxide. 12) Recently, we showed that FDP reduced the UVB-induced increase in cellular ROS levels in HaCaT keratinocytes.…”