Fructose consumption enhances glucocorticoid action in rat visceral adipose tissue

The impact of different fructose loads on insulin sensitivity, inflammation, and PSA-NCAM-mediated plasticity in the hippocampus of fructose-fed male rats

“…We presume that the differences in NEFA levels and IPGTT parameters originate from the molecular changes previously observed in visceral adipose tissue of these animals. 21,22 Specifically, we found that increased adipose tissue mass and adiposity in animals on 60% fructose (see Table 1) may be a consequence of elevated levels of adipogenic and lipogenic transcription factors, such as peroxisome-proliferator-activated receptor γ (PPARγ), sterol regulatory elementbinding protein-1 (SREBP-1), and lipin-1, paralleled with decreased glucocorticoid signalization. 22 In contrast, in animals on 10% fructose diet, we detected augmented glucocorticoid signalization and increased lipolysis in visceral adipose tissue, 21 probably resulting in elevated NEFA and consequently elevated AUC glucose levels.…”

Kinetic analysis for the isomerization of glucose, fructose, and mannose in subcritical aqueous ethanol

“…Fructose has positive health effects in humans as it enhances glucocorticoid action 1) and insulin resistance. 2) Recently, fructose has been used as a renewable resource to synthesize biofuels and biochemical 3,4) such as 5-hydroxymethylfurfural and methyl lactate.…”

Dietary Fructose and Glucose: The Multifacetted Aspects of Their Metabolism and Implication for Human Health

“…High fructose diet induces insulin resistance in skeletal muscle, with nuclear translocation of NF-κB 65, and subsequent secretion of IL-6, which is known to be mostly released from skeletal muscle [141]. Correspondingly, expression of inducible NOS (iNOS) and ICAM-1 is changed, suggesting that the possible role of insulin resistance in skeletal muscle may act in an NF-κB-dependent manner [142]. Peroxisome proliferator-activated receptor (PPAR)-δ, one of the most promising pharmacological targets implicated in obesity-associated insulin resistance, is highly expressed in skeletal muscle.…”

“…Bacterial DNA content was extracted using the QIAamp DNA Mini Kit (Qiagen, Valencia, CA, USA) according to the manufacturer's instructions. 142 Nutrients 2017, 9,393 Bacterial DNA was amplified by PCR with barcode universal bacterial primers targeting variable regions 3-4 of the 16S rRNA gene.…”

“…An enhanced expression of 11β-HSD1 as well as GR-regulated lipogenic genes accompanied by an induced adipogenesis was suggested by studies using Wistar rats on 10% fructose in the drinking water for a 9 week period [141][142][143]. Male rats that were subjected to both fructose-rich diet and chronic unpredictable stress had slightly elevated corticosterone levels, higher 11β-HSD1 expression (but not H6PDH, contrary with the previous animal study), and evidence for increased GR activation [142]. Also, acetyl-CoA-carboxylase, fatty acid synthase and hormone sensitive lipase expression levels were elevated.…”