The impact of different fructose loads on insulin sensitivity, inflammation, and PSA-NCAM-mediated plasticity in the hippocampus of fructose-fed male rats

Djordjević, Ana; Bursać, Biljana; Veličković, Nataša; Vasiljević, Ana; Matić, Gordana

doi:10.1179/1476830513y.0000000098

Cited by 26 publications

(21 citation statements)

References 38 publications

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“…Our findings are agreement with earlier reports that that combined supplementation of phenolic compounds have more potentials than individual treatment [45] [46]. Hyperglycemia is known to be one of the vital factors that can induce expression of inflammatory biomarkers during diabetes via oxidative stress pathways and associated rise in inflammatory path to induce neural cells death and dysfunction [47] [48]. Present findings obviously show the association between inflammation and the development of DN while the levels of pro-inflammatory biomarkers such as TNF-α, Il-1β and IL-6 were Data expressed as mean ± SD (n = 6).…”

Section: Discussionsupporting

confidence: 93%

Protective Effects of Combined Therapy of Rutin with Silymarin on Experimentally-Induced Diabetic Neuropathy in Rats

Al-Enazi¹

2014

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The management of diabetic neuropathy (DN) is still a challenge for physicians. Hyperglycemia induced oxidative stress involves in the development of diabetic neuropathy, which could be reversed by supplementation of antioxidants. In the present study, it has targeted the oxidative stress mediated nerve damage in DN by using combined therapy of rutin (RT) and silymarin (SM). Diabetes was induced by single streptozotocin (STZ, 65 mg/kg i.p.) injection. The diabetic rats were treated daily with RT (100 mg/kg), SM (60 mg/kg) and RT (50 mg/kg) + SM (30 mg/kg) for 6 consecutive weeks. Pain-related behavior tests were performed including tail flick, paw-pressure analgesia and Rota-rod treadmill performance. Serum glucose, insulin, tumor necrosis factor-α (TNF-α), interleukine-6 (IL-6) and interleukine-1β (IL-β) levels were estimated. Thiobarbituric acid reactive substances (TBARS), reduced glutathione (GSH) levels and enzymatic activities of superoxide dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST), glutathione reductase (GR) and glutathione peroxidase (GPx) were measured. Diabetic rats that developed neuropathy were revealed by decreased tail-flick latency, paw-withdrawal latency and motor coordination. RT (100 mg/kg/day) and SM (60 mg/kg/day) dosed to diabetic rats, ameliorated hyperalgesia, analgesia and led to improved motor coordination. However, the combined therapy of RT (50 mg/kg/day) with SM (30 mg/kg/day) showed more significant effects in these parameters. STZ significantly increased TBARS and decreased GSH levels in sciatic nerve whereas combined therapy of RT and SM produced higher significant protection compared to individual. Similarly, combined therapy showed more significant amelioration in decreased levels of SOD, CAT, GST, GS and GPx activities in sciatic nerve of diabetic rats. Present results concluded that the combined therapy of phenolic compounds such as RT and SM had higher protective effects than their individual supplementations against DM.

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Section: Discussionsupporting

confidence: 93%

Protective Effects of Combined Therapy of Rutin with Silymarin on Experimentally-Induced Diabetic Neuropathy in Rats

Al-Enazi¹

2014

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“…14,34 Moreover, diabetic-associated over expression of inflammatory biomarkers is recognised to provoke neural cells death and dysfunction. 35,36 Present data revealed that, NG Figure 5 Effects of naringenin (NG) on sciatic nerve activities of SOD, CAT, GPx and GR in diabetic rats. Data were expressed as Mean 6 SEM (n 5 6) and analysed using one-way ANOVA followed by Student Newman-Keuls as post hoc test.…”

Section: Discussionmentioning

confidence: 97%

Naringenin neutralises oxidative stress and nerve growth factor discrepancy in experimental diabetic neuropathy

Al‐Rejaie

Aleisa

Abuohashish

et al. 2015

Neurological Research

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“…Increased levels of inflammatory molecules are considered to be produced as a result of hyperglycemia and insulin resistance in diabetes (40,41). In addition, the diabetes-associated overexpression of inflammatory biomarkers is known to provoke neural cell dysfunction and death (42,43). Previous studies have indicated that Gs extract may exert a protective effect against inflammation (44,45).…”

Section: Discussionmentioning

confidence: 99%

Neuroprotective effects of Gymnema sylvestre on streptozotocin-induced diabetic neuropathy in rats

Fatani

Al‐Rejaie

Abuohashish

et al. 2015

Experimental and Therapeutic Medicine

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Abstract. The application of traditional medicine for diabetes and associated complications, such as diabetic neuropathy (DN), has received increasing attention. The aim of the present study was to investigate the potential ameliorative effect of Gymnema sylvestre (Gs) in a rat model of DN. Diabetes was induced via a single intraperitoneal injection of streptozotocin (STZ; 60 mg/kg). Treatment with Gs extract (50 or 100 mg/kg/day) began two weeks following the administration of STZ and was continued for five weeks. Pain threshold behavior tests were performed subsequent to the five-week Gs treatment period. In addition, the serum levels of glucose, insulin and proinflammatory cytokines, including tumor necrosis factor (TNF)-α, interleukin (IL)-1β and IL-6, were determined. Furthermore, the sciatic tissue levels of nitric oxide, thiobarbituric acid reactive substances and reduced glutathione were determined, as well as the activity levels of superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase. Levels of insulin-like growth factor (IGF), nerve growth factor (NGF), TNF-α, IL-1β and IL-6 were also assessed in the sciatic tissue. In addition, the sciatic nerve tissue samples were analyzed for histopathological alterations. The diabetic rats exhibited apparent reductions in the paw-withdrawal (31%; P<0.01) and tail-flick latencies (38%; P<0.05). Furthermore, the diabetic rats demonstrated an evident elevation in serum and sciatic levels of proinflammatory cytokines. Measured oxidative stress biomarkers were significantly altered in the sciatic nerve tissue of the diabetic rats. Treatment with Gs attenuated diabetes-induced modifications with regard to the levels of serum glucose, insulin and proinflammatory cytokines. In the sciatic nerve tissue, the diabetes-induced alterations in IL levels and oxidative stress biomarkers were significantly improved in the Gs-treated rats. Furthermore, the reduction in the sciatic tissue expression levels of IGF and NGF was also ameliorated by Gs treatment. Histological analysis indicated that Gs corrected the sciatic tissue in the diabetic rats. Therefore, the results demonstrated that the neuroprotective effect of Gs may be associated with the inhibitory effect on the excessive activation of inflammatory molecules and oxidative stress mediators.

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The impact of different fructose loads on insulin sensitivity, inflammation, and PSA-NCAM-mediated plasticity in the hippocampus of fructose-fed male rats

Cited by 26 publications

References 38 publications

Protective Effects of Combined Therapy of Rutin with Silymarin on Experimentally-Induced Diabetic Neuropathy in Rats

Protective Effects of Combined Therapy of Rutin with Silymarin on Experimentally-Induced Diabetic Neuropathy in Rats

Naringenin neutralises oxidative stress and nerve growth factor discrepancy in experimental diabetic neuropathy

Neuroprotective effects of Gymnema sylvestre on streptozotocin-induced diabetic neuropathy in rats

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